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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/10 00:19:04」(JST)

Timiperone is an antipsychotic of the butyrophenone class.^[1]^[2]

References

^ Pharmacological studies on timiperone, a new neuroleptic drug Part II: General pharmacological properties., Arzneimittelforschung. 1981;31(4):707-15, PMID 6113834 PubMed - indexed for MEDLINE
^ Effect of Timiperone, a New Antipsychotic Drug, on the Sleep-Wakefulness Cycle in Cats, The Japanese Journal of Pharmacology, Vol.39 , No.3(1985)pp.391-394

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Atypical properties of several classes of antipsychotic drugs on the basis of differential induction of Fos-like immunoreactivity in the rat brain.

Oka T1, Hamamura T, Lee Y, Miyata S, Habara T, Endo S, Taoka H, Kuroda S.
Life sciences.Life Sci.2004 Nov 26;76(2):225-37.
Acute administration of typical and atypical antipsychotics has been reported to induce regionally distinct patterns of c-Fos expression in the rat forebrain. Furthermore, atypical index, the difference in the extent of increased Fos-like immunoreactivity (Fos-LI) in the nucleus accumbens (NAc) shel
PMID 15519367

Effect of hyperprolactinemia induced by pituitary grafts or castration on porphyrin content of the mouse Harderian gland.

Kajimura T1, Satoh H, Watanabe G, Taya K.
The Journal of toxicological sciences.J Toxicol Sci.2001 Aug;26(3):151-61.
The histology and porphyrin concentrations of Harderian glands and plasma prolactin levels were examined in B6C3F1 mice castrated or isografted with pituitaries in combination with the administration of bromocriptine (2-bromo-á-ergocryptine), a potent suppressor of prolactin. Four pituitaries were
PMID 11552298

Shimoda K1, Shibasaki M, Inaba T, Cheung SW, Someya T, Takahashi S.
Pharmacology & toxicology.Pharmacol Toxicol.1998 Oct;83(4):164-8.
This in vitro study using human liver enzymes was undertaken in order to compare the mechanism of metabolic reduction of timiperone, a potent butyrophenone neuroleptic, with that of haloperidol. Conversion of timiperone to reduced timiperone in liver cytosol was confirmed. The carbonyl reductase inh
PMID 9820877

ANALYSIS OF BUTYROPHENONES IN WHOLE BLOOD SPECIMENS BY LC/MS/MS USING A NEW POLYMER COLUMN

Hattori Hideki,Arinobu Tetsuya,Iwai Masae,Masuda Kenji,Suzuki Osamu,Seno Hiroshi
2005-01-31
… The regression equations showed good linearity for haloperidol, bromperidol, moperone and spiroperidol in the range of 10-80 ng/ml, for timiperone in the range of 20-80 ng/ml and for pimozide in the range of 50-200 ng/ml using the chlorinated analog of haloperidol as internal standard, Their detection limits were about 5 ng/ml for haloperidol, bromperidol, moperone and spiroperidol, about 10 ng/ml for timiperone and about 25 ng/ml for pimozide. …
NAID 120005314065

服部秀樹,有信哲哉,岩井雅枝,水谷洋子,益田健史,妹尾洋,熊澤武志,李暁鵬,鈴木修
2004-04-01
… Six kinds of butyrophenones used in this research were detected with high sensitivity by LC/MS/MS. The detection limit in human hemolyzed blood was about 5 ng/ml except for timiperone and pimozide.rights:日本法中毒学会rights:本文データは日本法中毒学会の許諾のもと掲載しています。 …
NAID 120005314062

EFFECT OF HYPERPROLACTINEMIA INDUCED BY PITUITARY GRAFTS OR CASTRATION ON PORPHYRIN CONTENT OF THE MOUSE HARDERIAN GLAND

Kajimura Tetsuyo,Satoh Hiroshi,Watanabe Gen [他],TAYA Kazuyoshi
Journal of toxicological sciences 26(3), 151-161, 2001-08-07
… Furthermore, we investigated Harderian porphyrins and plasma testosterone levels in mice that were castrated or treated with neuroleptic butyrophenone (timiperone), a potent accelerator of prolactin, and treated concurrently with bromocriptine. …
NAID 110001806916

Timiperone
Systematic (IUPAC) name
	1-(4-fluorophenyl)-4-[4-(2-sulfanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]butan-1-one
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only);
Routes of; administration	Oral
Identifiers
CAS Number	57648-21-2
ATC code	None
PubChem	CID: 3033151
ChemSpider	2297930
UNII	626DQ7N19L
KEGG	D02035
Chemical data
Formula	C22H24FN3OS
Molecular mass	397.50 g/mol
	SMILES C1CN(CCC1N2C3=CC=CC=C3NC2=S)CCCC(=O)C4=CC=C(C=C4)F ;
	InChI InChI=1S/C22H24FN3OS/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28) ; Key:YDLQKLWVKKFPII-UHFFFAOYSA-N ;
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