ヨウ化チエモニウム
WordNet
- a salt or ester of hydriodic acid
PrepTutorEJDIC
- ヨウ化物
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/02/06 19:26:25」(JST)
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Tiemonium iodide
|
Systematic (IUPAC) name |
4-[3-hydroxy-3-phenyl-3-(2-thienyl)propyl]-4-methylmorpholin-4-ium iodide |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Legal status |
? |
Identifiers |
CAS number |
144-12-7 |
ATC code |
A03AB17 |
PubChem |
CID 72142 |
UNII |
FZ2LZ7U304 Y |
KEGG |
D01201 |
Chemical data |
Formula |
C18H24INO2S |
Mol. mass |
445.36 g/mol |
Tiemonium iodide is an antimuscarinic. It is poorly absorbed from the gut. The active moiety is tiemonium, a quaternary ammonium cation.[1]
References[edit]
- ^ Scoular, I. T.; Monks, Anne; Burgess, C.; Turner, P. (1977). "Human studies on the bioavailability of a quaternary ammonium compound, tiemonium iodide and tiemonium methosulphate". Current Medical Research and Opinion 4 (10): 732–8. doi:10.1185/03007997609112009. PMID 1052164.
Drugs for functional gastrointestinal disorders (A03)
|
|
Drugs for
functional
bowel disorders |
Antimuscarinics
|
Tertiary
amino group
|
- Oxyphencyclimine
- Camylofin
- Mebeverine
- Trimebutine
- Rociverine
- Dicycloverine
- Dihexyverine
- Difemerine
- Piperidolate
|
|
Quaternary
ammonium
compounds
|
- Benzilone
- Mepenzolate
- Pipenzolate
- Glycopyrronium
- Oxyphenonium
- Penthienate
- Methantheline
- Propantheline
- Otilonium
- Tridihexethyl
- Isopropamide
- Hexocyclium
- Poldine
- Bevonium
- Diphemanil
- Tiemonium
- Prifinium
- Timepidium
- Fenpiverinium
|
|
|
Phosphodiesterase
inhibitors
|
- Papaverine
- Drotaverine
- Moxaverine
|
|
Acting on
serotonin receptors
|
- 5-HT3 antagonists
- 5-HT4 agonists
- Mosapride
- Prucalopride
- Tegaserod
|
|
Other
|
- Alverine
- Caroverine
- Chlorbenzoxamine
- Diisopromine
- Dimethylaminopropionylphenothiazine
- Fenpiprane
- Fenoverine
- Idanpramine
- Isometheptene
- Phloroglucinol
- Pinaverium
- Proxazole
- Silicones
- Tiropramide
- Trepibutone
- Trimethyldiphenylpropylamine
|
|
|
Belladonna
and derivatives
(antimuscarinics) |
- tertiary amines: Atropine
- Hyoscyamine
- quaternary ammonium compounds:
- Scopolamine
- Butylscopolamine
- Methylscopolamine
- Methylatropine
- Fentonium
- Cimetropium bromide
|
|
Propulsives |
- primarily dopamine antagonists
- Metoclopramide/Bromopride
- Clebopride
- Domperidone
- Alizapride
- 5-HT4 agonists
|
|
|
anat (t, g, p)/phys/devp/enzy
|
noco/cong/tumr, sysi/epon
|
proc, drug (A2A/2B/3/4/5/6/7/14/16), blte
|
|
|
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UpToDate Contents
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English Journal
- Direct asymmetric catalytic thienylaluminum addition to ketones: a concise approach to the synthesis of (S)-tiemonium iodide.
- Biradar DB, Zhou S, Gau HM.SourceDepartment of Chemistry, National Chung Hsing University, Taichung 402, Taiwan.
- Organic letters.Org Lett.2009 Aug 6;11(15):3386-9. doi: 10.1021/ol901193q.
- A direct asymmetric addition of a (2-thienyl)aluminum reagent to ketones catalyzed by a titanium catalyst of (S)-BINOL to afford chiral tertiary 2-thienyl alcohols is reported. The catalytic system works excellently for aromatic ketones and for 1-acetylcyclohexene, furnishing products in excellent e
- PMID 19588914
- Orofacial dyskinesia associated with tiemonium.
- Klouz A, Zaïem A, Trabelsi S, Loueslati MH, Lakhal M, Belkahia C.SourceCentre National de Pharmacovigilance, Sis Hôpital Charles Nicolle, Boulevard du 9 Avril 1938, 1006 Tunis-Bab Souika, Tunisia.
- Fundamental & clinical pharmacology.Fundam Clin Pharmacol.2007 Dec;21(6):657-8.
- Tiemonium, an anti-spasmodic drug, can have adverse effects related to its anti-muscarinic effect. Dyskinesia is described with other anti-cholinergic drugs, but there are no reports of dyskinesia associated with tiemonium. We report a reversible orofacial dyskinesia following tiemonium intake (cont
- PMID 18034667
- Markedly altered colchicine kinetics in a fatal intoxication: examination of contributing factors.
- Borron SW, Scherrmann JM, Baud FJ.SourceHôpital Fernand Widal, Université Paris VII, France.
- Human & experimental toxicology.Hum Exp Toxicol.1996 Nov;15(11):885-90.
- 1. Colchicine poisoning, which is relatively rare, is associated with significant morbidity and mortality. Whilst a new treatment modality, in the form of colchicine-specific Fab fragments is on the horizon, currently available therapy is largely supportive. 2. The elimination of colchicine occurs p
- PMID 8938483
Japanese Journal
- Tiemonium iodideのイヌ生体位結腸運動に及ぼす影響
- 岡田 謙司 [他],今井 浩達,外川 芳子,野崎 正勝,鶴見 介登,藤村 一,長岡 俊治
- 日本薬理学雑誌 80(6), 495-503, 1982
- … tiemonium iodide(tiemonium,20μg/kg i.v.)のイヌ生体位結腸運動に及ぼす効果をmepenzolate bromide(mepenzolate,20μg/kg i.v.),butylscopolamine bromide(butylscopolamine,50μg/kg i.v.)およびatropine sulfate(atropine,10μg/kg i.v.)と比較検討した.バルーン法で得た結腸運動波形を高速フーリエ変により解析し,またパワースペクトルの第1項値をtonus indexとして腸管緊張の指標とした.結腸正常運動は近位部で1および4 …
- NAID 130000760447
- 卵管疎通性に対するVisceralgine(Tiemonium iodide)の影響
- Tiemonium Iodide(Visceralgine)の尿管運動に対する作用に関する臨床実験ならびにその使用成績
- 岡 直友 [他],和志田 裕人
- 泌尿器科紀要 16(10), 608-618, 1970-10
- … Effect of tiemonium iodide (Visceralgine) on normal ureteral contractile activity was studied on 15 human subjects (25 ureters) by means of strain gauge manometer. …
- NAID 120002232383
Related Links
- Tiemonium Iodide is a medicine available in a number of countries worldwide. A list of US medications equivalent to Tiemonium Iodide is available on the Drugs.com website. ... Drugs.com provides accurate and independent ...
- Structure, properties, spectra, suppliers and links for: Tiemonium iodide, 144-12-7. ... CSID:65116, http://www.chemspider.com/Chemical-Structure.65116.html (accessed 15:07, May 20, 2015) Copy Copied
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- 関
- I、I2、iodine、iodo