thyrotropin-releasing hormone receptor

• サイロトロピン放出ホルモン受容体、サイロトロピン放出ホルモンレセプター、甲状腺刺激ホルモン放出ホルモン受容体、甲状腺刺激ホルモン放出ホルモンレセプター

関

TRH receptor

WordNet

1. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
2. the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion
3. anterior pituitary hormone that stimulates the function of the thyroid gland (同)thyrotropic hormone, thyrotrophin, thyrotrophic hormone, thyroid-stimulating_hormone, TSH

PrepTutorEJDIC

1. =sense organ / 受信装置
2. ホルモン

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/07 05:01:37」(JST)

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TRHR
Identifiers
Aliases	TRHR, TRH-R, thyrotropin releasing hormone receptor
External IDs	OMIM: 188545 MGI: 98824 HomoloGene: 20707 GeneCards: 7201
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • thyrotropin-releasing hormone receptor activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • signal transduction • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7201	22045
Ensembl	ENSG00000174417	ENSMUSG00000038760
UniProt	P34981	P21761
RefSeq (mRNA)	NM_003301	NM_013696
RefSeq (protein)	NP_003292.1	NP_038724.1
Location (UCSC)	Chr 8: 109.09 – 109.12 Mb	Chr 15: 44.2 – 44.24 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

The thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds the tripeptide thyrotropin releasing hormone.

The TRHR are found in the brain and when bound by TRH act (through phospholipase C) to increase intracellular inositol trisphosphate.

References

Further reading

• Short RE, James LF, Panter KE, Staigmiller RB, Bellows RA, Malcolm J, Ford SP (November 1992). "Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep". Journal of Animal Science. 70 (11): 3498–504. PMID 1459912. 
• Yamada M, Iwasaki T, Satoh T, Monden T, Konaka S, Murakami M, Iriuchijima T, Mori M (August 1995). "Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly". Neuroscience Letters. 196 (1-2): 109–12. doi:10.1016/0304-3940(95)11861-P. PMID 7501234. 
• Hinuma S, Hosoya M, Ogi K, Tanaka H, Nagai Y, Onda H (October 1994). "Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene". Biochimica et Biophysica Acta. 1219 (2): 251–9. doi:10.1016/0167-4781(94)90046-9. PMID 7918619. 
• Morrison N, Duthie SM, Boyd E, Eidne KA, Connor JM (June 1994). "Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization". Human Genetics. 93 (6): 716–8. doi:10.1007/bf00201580. PMID 8005602. 
• Yamada M, Monden T, Konaka S, Mori M (November 1993). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8". Somatic Cell and Molecular Genetics. 19 (6): 577–80. doi:10.1007/BF01233384. PMID 8128317. 
• Duthie SM, Taylor PL, Anderson L, Cook J, Eidne KA (September 1993). "Cloning and functional characterisation of the human TRH receptor". Molecular and Cellular Endocrinology. 95 (1-2): R11–5. doi:10.1016/0303-7207(93)90043-J. PMID 8243797. 
• Matre V, Karlsen HE, Wright MS, Lundell I, Fjeldheim AK, Gabrielsen OS, Larhammar D, Gautvik KM (August 1993). "Molecular cloning of a functional human thyrotropin-releasing hormone receptor". Biochemical and Biophysical Research Communications. 195 (1): 179–85. doi:10.1006/bbrc.1993.2027. PMID 8395824. 
• Yamada M, Monden T, Satoh T, Satoh N, Murakami M, Iriuchijima T, Kakegawa T, Mori M (September 1993). "Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene". Biochemical and Biophysical Research Communications. 195 (2): 737–45. doi:10.1006/bbrc.1993.2107. PMID 8396925. 
• Iwasaki T, Yamada M, Satoh T, Konaka S, Ren Y, Hashimoto K, Kohga H, Kato Y, Mori M (September 1996). "Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene". The Journal of Biological Chemistry. 271 (36): 22183–8. doi:10.1074/jbc.271.36.22183. PMID 8703031. 
• Cook JV, McGregor A, Lee T, Milligan G, Eidne KA (July 1996). "A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor". Endocrinology. 137 (7): 2851–8. doi:10.1210/en.137.7.2851. PMID 8770906. 
• Collu R, Tang J, Castagné J, Lagacé G, Masson N, Huot C, Deal C, Delvin E, Faccenda E, Eidne KA, Van Vliet G (May 1997). "A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene". The Journal of Clinical Endocrinology and Metabolism. 82 (5): 1561–5. doi:10.1210/jc.82.5.1561. PMID 9141550. 
• Petrou C, Tashjian AH (September 1998). "The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles". Cellular Signalling. 10 (8): 553–9. doi:10.1016/S0898-6568(97)00190-3. PMID 9794253. 
• Matre V, Høvring PI, Orstavik S, Frengen E, Rian E, Velickovic Z, Murray-McIntosh RP, Gautvik KM (January 1999). "Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor". Journal of Neurochemistry. 72 (1): 40–50. doi:10.1046/j.1471-4159.1999.0720040.x. PMID 9886052. 
• Kroeger KM, Hanyaloglu AC, Seeber RM, Miles LE, Eidne KA (April 2001). "Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer". The Journal of Biological Chemistry. 276 (16): 12736–43. doi:10.1074/jbc.M011311200. PMID 11278883. 
• Zhu CC, Cook LB, Hinkle PM (August 2002). "Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation". The Journal of Biological Chemistry. 277 (31): 28228–37. doi:10.1074/jbc.M204221200. PMID 12023974. 
• Hanyaloglu AC, Seeber RM, Kohout TA, Lefkowitz RJ, Eidne KA (December 2002). "Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2". The Journal of Biological Chemistry. 277 (52): 50422–30. doi:10.1074/jbc.M209340200. PMID 12393857. 
• Cook LB, Zhu CC, Hinkle PM (September 2003). "Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation". Molecular Endocrinology. 17 (9): 1777–91. doi:10.1210/me.2003-0073. PMID 12805411. 
• Igarashi-Migitaka J, Yamada S, Hara M, Sano T, Ozawa Y, Ohtani-Kaneko R, Hirata K (August 2003). "Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas". Endocrine Journal. 50 (4): 459–67. doi:10.1507/endocrj.50.459. PMID 14599121. 
• Cook LB, Hinkle PM (July 2004). "Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein". Endocrinology. 145 (7): 3095–100. doi:10.1210/en.2004-0304. PMID 15117874. 

External links

• "Thyrotropin-Releasing Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
• Receptors, Thyrotropin-Releasing Hormone at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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• 1. 甲状腺刺激ホルモンおよび甲状腺刺激ホルモン放出ホルモンに対する抵抗性 resistance to thyrotropin and thyrotropin releasing hormone
• 2. 甲状腺機能低下症の原因となる疾患 disorders that cause hypothyroidism
• 3. 先天性甲状腺機能低下症の臨床的特徴および検出 clinical features and detection of congenital hypothyroidism
• 4. 中枢性甲状腺機能低下症 central hypothyroidism
• 5. 甲状腺刺激ホルモン（TSH）分泌下垂体腺腫 thyrotropin tsh secreting pituitary adenomas

English Journal

• A screen for modulators reveals that orexin-A rapidly stimulates thyrotropin releasing hormone expression and release in hypothalamic cell culture.

• Cote-Vélez A1, Martínez Báez A1, Lezama L1, Uribe RM1, Joseph-Bravo P1, Charli JL2.
• Neuropeptides.Neuropeptides.2017 Feb 2. pii: S0143-4179(16)30120-2. doi: 10.1016/j.npep.2017.01.005. [Epub ahead of print]
• In the paraventricular nucleus of the mammalian hypothalamus, hypophysiotropic thyrotropin releasing hormone (TRH) neurons integrate metabolic information and control the activity of the thyroid axis. Additional populations of TRH neurons reside in various hypothalamic areas, with poorly defined con
• PMID 28173961

• In vivo Functional Consequences of Human THRA Variants Expressed in the Zebrafish.

• Marelli F1, Carra S2, Rurale G3, Cotelli F2, Persani L1,3.
• Thyroid : official journal of the American Thyroid Association.Thyroid.2017 Feb;27(2):279-291. doi: 10.1089/thy.2016.0373. Epub 2016 Dec 9.
• BACKGROUND: Heterozygous mutations in the thyroid hormone receptor alpha (THRA) gene cause resistance to thyroid hormone alpha (RTHα), a disease characterized by variable manifestations reminiscent of untreated congenital hypothyroidism but a raised triiodothyronine/thyroxine ratio and normal thyro
• PMID 27809680

• Di2-ethylhexyl phthalate disrupts thyroid hormone homeostasis through activating the Ras/Akt/TRHr pathway and inducing hepatic enzymes.

• Ye H1, Ha M2, Yang M3, Yue P3, Xie Z1, Liu C3.
• Scientific reports.Sci Rep.2017 Jan 9;7:40153. doi: 10.1038/srep40153.
• Di(2-ethylhexyl) phthalate (DEHP), as a widespread environmental pollutant and an endocrine disruptor, can disturb the homeostasis of thyroid hormones (THs). In order to elucidate roles of the MAPK and PI3K/Akt pathways and hepatic enzymes in thyroid-disrupting effects of DEHP, Sprague-Dawley rats w
• PMID 28065941

Japanese Journal

• IDENTIFICATION OF cDNAS ENCODING THYROTROPIN-RELEASING HORMONE RECEPTOR FROM THE BULLFROG

• MINAGAWA Atsuko,HASUNUMA Itaru,NAKANO Mmaki,OKADA Reiko,YAMAMOTO Kazutoshi,KIKUYAMA Sakae,KOBAYASHI Tetsuya,MACHIDA Takeo
• Proceedings of the Japan Society for Comparative Endocrinology (22), 78, 2007-10-12
• NAID 10020188496

• 下垂体腺腫におけるGsα遺伝子変異の検討

• 大竹 啓之,三木 伸泰,小野 昌美 [他],堀 智勝,高野 加寿恵,OHTAKE Hiroyuki,MIKI Nobuhiro,ONO Masami,HORI Tomokatsu,TAKANO Kazue
• 東京女子医科大学雑誌 77(5), 256-263, 2007-05-00
• … Activating mutations of the Gsα protein coupled to the growth hormone-releasing hormone (GRH) receptor contribute to the genesis of growth hormone (GH)-secreting pituitary adenomas. … The GH response to GRH was significantly lower, while that to thyrotropin-releasing hormone (TRH) was significantly higher, in the patients with the Gsα mutations. …
• NAID 110007525243

• A selective orexin-1 receptor antagonist, SB334867, blocks 2-DG-induced gastric acid secretion in rats

• 奥村 利勝,Yamada H; Takahashi N; Tanno S; Nagamine M; Takakusaki K; Okumura T
• NEUROSCIENCE LETTERS 376(2), 137-142, 2005-11-Mar
• … It has also been suggested that the stimulation of acid by central orexin-A may be mediated by orexin 1 receptor (OX_1R) in the brain. … Pretreatment with SB334867 in a dose of 10 mg/kg completely blocked the stimulated acid output by intracisternal orexin-A but not thyrotropin-releasing hormone, suggesting that SB334867 specifically blocked the action of orexin-A in the brain. …
• NAID 120001024633

Related Links

• TRHR - Thyrotropin-releasing hormone receptor - Homo ...

Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. ... 100% UniRef100 combines identical sequences and sub-fragments ...

• Thyrotropin-releasing hormone receptors -- similarities and ...

1. J Mol Endocrinol. 2003 Apr;30(2):87-97. Thyrotropin-releasing hormone receptors -- similarities and differences. Sun Y(1), Lu X, Gershengorn MC. Author information: (1)National Institute of Diabetes and Digestive and ...

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★リンクテーブル★

リンク元	「甲状腺刺激ホルモン放出ホルモン受容体」「甲状腺刺激ホルモン放出ホルモンレセプター」「サイロトロピン放出ホルモン受容体」「サイロトロピン放出ホルモンレセプター」「TRH receptor」
関連記事	「hormone receptor」「thyrotropin」

「甲状腺刺激ホルモン放出ホルモン受容体」

　　[★]

英

thyrotropin-releasing hormone receptor、TRH receptor

関

甲状腺刺激ホルモン放出ホルモンレセプター、サイロトロピン放出ホルモン受容体、サイロトロピン放出ホルモンレセプター、TRHレセプター、TRH受容体

「甲状腺刺激ホルモン放出ホルモンレセプター」

　　[★]

英

thyrotropin-releasing hormone receptor、TRH receptor

関

甲状腺刺激ホルモン放出ホルモン受容体、サイロトロピン放出ホルモン受容体、サイロトロピン放出ホルモンレセプター、TRHレセプター、TRH受容体

「サイロトロピン放出ホルモン受容体」

　　[★]

英

thyrotropin-releasing hormone receptor

関

甲状腺刺激ホルモン放出ホルモンレセプター、甲状腺刺激ホルモン放出ホルモン受容体、サイロトロピン放出ホルモンレセプター

「サイロトロピン放出ホルモンレセプター」

　　[★]

英

thyrotropin-releasing hormone receptor

関

甲状腺刺激ホルモン放出ホルモンレセプター、甲状腺刺激ホルモン放出ホルモン受容体、サイロトロピン放出ホルモン受容体

「TRH receptor」

　　[★]

• 甲状腺刺激ホルモン放出ホルモン受容体、甲状腺刺激ホルモン放出ホルモンレセプター、TRH受容体、TRHレセプター

関

thyrotropin-releasing hormone receptor

「hormone receptor」

　　[★]

• ホルモン受容体、ホルモンレセプター

「thyrotropin」

　　[★] 甲状腺刺激ホルモン