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English Journal

PDGF Enhances Orbital Fibroblast Responses to TSHR Stimulating Autoantibodies in Graves' Ophthalmopathy Patients.

van Steensel L, Hooijkaas H, Paridaens D, van den Bosch WA, Kuijpers RW, Drexhage HA, van Hagen PM, Dik WA.SourceDepartment of Immunology, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. w.dik@erasmusmc.nl.
The Journal of clinical endocrinology and metabolism.J Clin Endocrinol Metab.2012 Jun;97(6):E944-53. Epub 2012 Mar 21.
Purpose: Thyroid-stimulating hormone receptor (TSHR) stimulating autoantibodies are associated with Graves' ophthalmopathy (GO), the orbital manifestation of Graves' disease (GD). TSHR autoantibody levels and orbital TSHR expression levels correlate positively with GO disease activity. Platelet-deri
PMID 22438231

A TSHR-LH/CGR Chimera that Measures Functional Thyroid-Stimulating Autoantibodies (TSAb) Can Predict Remission or Recurrence in Graves' Patients Undergoing Antithyroid Drug (ATD) Treatment.

Giuliani C, Cerrone D, Harii N, Thornton M, Kohn LD, Dagia NM, Bucci I, Carpentieri M, Di Nenno B, Di Blasio A, Vitti P, Monaco F, Napolitano G.SourceUnit of Endocrinology (C.G., D.C., I.B., M.C., B.D.N., A.D.B., F.M., G.N.), Department of Medicine and Sciences of Aging, University "G. D'Annunzio" and Aging Research Center, "Gabriele D'Annunzio" University Foundation, 66013 Chieti-Pescara, Italy; Department of Biomedical Sciences (N.H., M.T., L.D.K.), College of Osteopathic Medicine, Edison Biotechnology Institute, and Department of Chemical and Biomolecular Engineering (N.M.D.), Ohio University, Athens, Ohio 45701; and Department of Endocrinology P.V.), University of Pisa, 56127 Pisa, Italy.
The Journal of clinical endocrinology and metabolism.J Clin Endocrinol Metab.2012 Apr 6. [Epub ahead of print]
Context:A functional thyroid-stimulating autoantibodies (TSAb) assay using a thyroid-stimulating hormone receptor chimera (Mc4) appears to be clinically more useful than the commonly used assay, a binding assay that measures all the antibodies binding to the thyroid-stimulating hormone receptor with
PMID 22492869

Diagnosis and discrimination of autoimmune Graves' disease and Hashimoto's disease using thyroid-stimulating hormone receptor-containing recombinant proteoliposomes(MEDICAL BIOTECHNOLOGY)

Fukushima Hidetaka,Matsuo Hideaki,Imamura Koji [他],Morino Kazuhiko,Okumura Katsuzumi,Tsumoto Kanta,Yoshimura Tetsuro
Journal of bioscience and bioengineering 108(6), 551-556, 2009-12
… Graves' disease (GD) is an autoimmune disease of the thyroid gland caused by autoantibodies against thyroid-stimulating hormone receptor (TSHR). …
NAID 110007503224

Thyroid Dysfunction Induced by Interferon Therapy for the Treatment of Hepatitis Type C. A Report of 4 Cases.:A Report of 4 Cases

YAMAKAWA YOSUKE,SATA MICHIO,NAKANO HITOSHI,IDE TATSUYA,NOGUCHI SEIJI,TOKESHI SHIGERU,TANIKAWA KYUICHI
Ｔｈｅ　Ｋｕｒｕｍｅ　Ｍｅｄｉｃａｌ　Ｊｏｕｒｎａｌ 42(4), 313-319, 1995
… We describe 4 patients with onset or aggravation of thyroid dysfunction induced by interferon (IFN) treatment of hepatitis type C. … The onset or aggravation of thyroid dysfunction occurred during administration of IFN in 1 patient and 4 weeks after the end of IFN therapy in the remaining 3 patients. … The 2 patients who demonstrated hyperthyroidism were euthyroid and negative for thyroid autoantibodies before receiving IFN therapy. …
NAID 130000883026

A Case of Hypothyroidism with Simultaneous Presence of Stimulating Type Anti-thyrotropin (TSH) Receptor Antibodies and Anti-thyroxine (T4) Autoantibodies.

OHSHIRO KENWA,SAKATA SHIGEKI,MATSUDA MASAFUMI,KOMAKI TAKASHI,SAITO MASAYUKI,GOSHIMA EIICHI,KITADA MASAHISA
Endocrinologia Japonica 39(3), 245-250, 1992
… have examined a hypothyroid patient with stimulating type anti-thyrotropin (TSH) receptor antibodies and without blocking type anti-TSH receptor antibodies.Although she had high serum TSH (240μU/ml) and low free triiodothyronine (FT3, 0.49pg/ml) concentrations, which agree with physical findings of hypothyroidism, she had an unusually high free thyroxine (FT4) concentration (3.56ng/dl).Incubation of …
NAID 130000952631