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- 1. ヘキソースリン酸側路およびグルタチオン代謝関連疾患 related disorders of the hexose monophosphate shunt and glutathione metabolism
- 2. 炎症性ミオパチーの病因 pathogenesis of inflammatory myopathies
- 3. 成人の皮膚筋炎および多発性筋炎の臨床症状と診断 clinical manifestations and diagnosis of adult dermatomyositis and polymyositis
- 4. シャルコーマリートゥース病などの一次性の遺伝性運動感覚性ニューロパチー hereditary primary motor sensory neuropathies including charcot marie tooth disease
- 5. 成人における皮膚筋炎および多発性筋炎の初期治療 initial treatment of dermatomyositis and polymyositis in adults
English Journal
- Idiopathic inflammatory myopathies and the anti-synthetase syndrome: A comprehensive review.
- Mahler M1, Miller FW2, Fritzler MJ3.Author information 1INOVA Diagnostics, Inc., San Diego, CA, USA.2NIEHS, National Institutes of Health, DHHS, Bethesda, MD, USA.3Department of Medicine, University of Calgary, Calgary, Canada. Electronic address: fritzler@ucalgary.ca.AbstractAutoantibodies are a hallmark in the diagnosis of many systemic autoimmune rheumatic diseases (SARD) including idiopathic inflammatory myopathies (IIM). Based on their specificity, autoantibodies in IIM are grouped into myositis specific (MSA) and myositis associated autoantibodies (MAA). Among the MSA, autoantibodies against aminoacyl-tRNA synthetases (ARS) represent the most common antibodies and can be detected in 25-35% of patients. The presence of ARS and other autoantibodies has become a key feature for classification and diagnosis of IIM and is increasingly used to define clinically distinguishable IIM subsets. For example, anti-ARS autoantibodies are the key features of what has become known as anti-synthetase syndrome (aSS), characterized by multiple organ involvement, primarily interstitial lung disease, often accompanied by myositis, non-erosive arthritis, Raynaud's phenomenon, fever, and "mechanic's hands". Autoantibodies directed to eight different ARS have been described: Jo-1 (histidyl), PL-7 (threonyl), PL-12 (alanyl), OJ (isoleucyl), EJ (glycyl), KS (asparaginyl), Zo (phenylalanyl) and Ha (tyrosyl). Each anti-ARS antibody seems to define a distinctive clinical phenotype. Although several research methods and commercial tests are available, routine testing for anti-ARS autoantibodies (other than anti-Jo-1/histidyl-tRNA synthetase) is not widely available, sometimes leading to delays in diagnosis and poor disease outcomes.
- Autoimmunity reviews.Autoimmun Rev.2014 April - May;13(4-5):367-371. doi: 10.1016/j.autrev.2014.01.022. Epub 2014 Jan 11.
- Autoantibodies are a hallmark in the diagnosis of many systemic autoimmune rheumatic diseases (SARD) including idiopathic inflammatory myopathies (IIM). Based on their specificity, autoantibodies in IIM are grouped into myositis specific (MSA) and myositis associated autoantibodies (MAA). Among the
- PMID 24424190
- Genetic validation of Aminoacyl tRNA synthetases as drug targets in Trypanosoma brucei.
- Kalidas S1, Cestari I, Monnerat S, Li Q, Regmi S, Hasle N, Labaied M, Parsons M, Stuart K, Phillips MA.Author information 1Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Rd, Dallas, TX 75390-9041.AbstractHuman African Trypanosomiasis (HAT) is an important public health threat in sub-Saharan Africa. Current drugs are unsatisfactory and new drugs are being sought. Few validated enzyme targets are available to support drug discovery efforts, so our goal was to obtain essentiality data on genes with proven utility as drug targets. Aminoacyl-tRNA synthetases (aaRS) are known drug targets for bacterial and fungal pathogens and are required for protein synthesis. Herein we survey the essentiality of eight Trypanosoma brucei aaRSs by RNAi gene expression knockdown, covering an enzyme from each major aaRS class: Valyl-tRNA synthease (ValRS) (class Ia), Tryptophanyl-tRNA synthetase (TrpRS-1)(class Ib), Arginyl-tRNA synthetase (ArgRS)(class Ic), Glutamyl-tRNA synthetase (GluRS) (class 1c), Threonyl-tRNA synthetase (ThrRS)(class IIa), Asparaginyl-tRNA synthetase (AsnRS) (class IIb), and Phenylalanyl-tRNA synthetase (α and β) (PheRS) (class IIc). Knockdown of mRNA encoding these enzymes in T. brucei mammalian stage parasites showed that all were essential for parasite growth and survival in vitro. The reduced expression resulted in growth, morphological, cell cycle and DNA content abnormalities. ThrRS was characterized in greater detail, showing that the purified recombinant enzyme displayed ThrRS activity and that the protein localized to both the cytosol and mitochondrion. Borrelidin, a known inhibitor of ThrRS, was an inhibitor of T. brucei ThrRS and showed anti-trypanosomal activity. The data show that aaRSs are essential for T. brucei survival, and are likely to be excellent targets for drug discovery efforts.
- Eukaryotic cell.Eukaryot Cell.2014 Feb 21. [Epub ahead of print]
- Human African Trypanosomiasis (HAT) is an important public health threat in sub-Saharan Africa. Current drugs are unsatisfactory and new drugs are being sought. Few validated enzyme targets are available to support drug discovery efforts, so our goal was to obtain essentiality data on genes with pro
- PMID 24562907
- AtObgC-AtRSH1 interaction may play a vital role in stress response signal transduction in Arabidopsis.
- Chen J1, Bang WY2, Lee Y3, Kim S3, Lee KW3, Kim SW4, Son YS3, Kim DW3, Akhter S3, Bahk JD5.Author information 1Agronomy College, Sichuan Agricultural University, Chengdu 611130, China; Division of Applied Life Sciences (BK21+), Graduate School of Gyeongsang National University, Jinju 660-701, Republic of Korea.2Department of Horticultural Sciences, Texas A&M University, College Station, TX 77843-2133, USA.3Division of Applied Life Sciences (BK21+), Graduate School of Gyeongsang National University, Jinju 660-701, Republic of Korea.4Green Bio Research Center, Cabbage Genomics Assisted Breeding Supporting Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Korea.5Division of Applied Life Sciences (BK21+), Graduate School of Gyeongsang National University, Jinju 660-701, Republic of Korea. Electronic address: jdbahk@gnu.ac.kr.AbstractThe interaction of Obg (Spo0B-associated GTP-binding protein) GTPase and SpoT, which is a bifunctional ppGpp (guanosine 3',5'-bispyrophosphate) hydrolase/synthetase, is vital for the modulation of intracellular ppGpp levels during bacterial responses to environmental cues. It has been recently reported that the ppGpp level is also inducible by various stresses in the chloroplasts of plant cells. However, the function of the Obg-SpoT interaction in plants remains elusive. The results from the present and previous studies suggest that AtRSH1 is a putative bacterial SpoT homolog in Arabidopsis and that its transcription levels are responsive to wounding and salt stresses. In this study, we used a yeast two-hybrid analysis to map the regions required for the AtObgC-AtRSH1 interaction. Moreover, protein-protein docking simulations revealed reasonable geometric and electrostatic complementarity in the binding surfaces of the two proteins. The data support our experimental results, which suggest that the conserved domains in AtObgC and the N terminus of AtRSH1 containing the TGS domain contribute to their interaction. In addition, quantitative real-time PCR (qRT-PCR) analyses showed that the expression of AtObgC and AtRSH1 exhibit a similar inhibition pattern under wounding and salt-stress conditions, but the inhibition pattern was not greatly influenced by the presence or absence of light. Based on in vivo analyses, we further confirmed that the AtRSH1 and AtObgC proteins similarly localize in chloroplasts. Based on these results, we propose that the AtObgC-AtRSH1 interaction plays a vital role in ppGpp-mediated stress responses in chloroplasts.
- Plant physiology and biochemistry : PPB / Société française de physiologie végétale.Plant Physiol Biochem.2014 Jan;74:176-84. doi: 10.1016/j.plaphy.2013.10.022. Epub 2013 Nov 22.
- The interaction of Obg (Spo0B-associated GTP-binding protein) GTPase and SpoT, which is a bifunctional ppGpp (guanosine 3',5'-bispyrophosphate) hydrolase/synthetase, is vital for the modulation of intracellular ppGpp levels during bacterial responses to environmental cues. It has been recently repor
- PMID 24308987
Japanese Journal
- Antisynthetase Syndrome Associated with Sarcoidosis
- Asanuma Yu,Koichihara Reiko,Koyama Shinichiro,Kawabata Yoshinori,Kobayashi Shio,Mimori Tsuneyo,Moriguchi Masato
- Internal Medicine 45(18), 1065-1068, 2006
- … The clinical findings and laboratory data included myositis, polyarthritis, interstitial pneumonia, Raynauds phenomenon, mechanics hand, and anti PL-7 antibody (threonyl-tRNA synthetase antibody). …
- NAID 130000076442
- Anti-angiogenesis Effects of Borrelidin are Mediated through Distinct Pathways : Threonyl-tRNA Synthetase and Caspases are Independently Involved in Suppression of Proliferation and Induction of Apoptosis in Endothelial Cells
- KAWAMURA TAKANORI,LIU DIANA,TOWLE MURRAY J.,KAGEYAMA RENA,TSUKAHARA NAOKO
- Journal of antibiotics 56(8), 709-715, 2003-08-25
- NAID 10011437377
Related Links
- 1. Biol Chem Hoppe Seyler. 1995 Apr;376(4):213-24. Threonyl-tRNA synthetase. Freist W, Gauss DH. Max-Planck-Institut für experimentelle Medizin, Göttingen, Germany. Threonine contributes to the solubility and reactivity of ...
- TEXT Description The TARS2 gene encodes mitochondrial threonyl-tRNA (Thr-tRNA) synthetase, which is involved in mitochondrial translation (summary by Diodato et al., 2014)
Related Pictures
★リンクテーブル★
| リンク元 | 「スレオニルtRNA合成酵素」「threonine-tRNA ligase」「スレオニルtRNAシンテターゼ」 |
| 関連記事 | 「synthetase」「tRNA」「tRNAs」「threonyl」 |
「スレオニルtRNA合成酵素」
「threonine-tRNA ligase」
「スレオニルtRNAシンテターゼ」
「synthetase」
- n.
「tRNA」
[★] トランスファーRNA, transfer RNA, 転位RNA