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English Journal

Comparison of three methods for measuring thiopurine methyltransferase activity in red blood cells and human leukemia cells.

Karim H, Appell ML, Fotoohi A.SourceDepartment of Medicine, Clinical Pharmacology Unit, Karolinska Institutet, Karolinska University Hospital, SE-171 76 Stockholm, Sweden. Electronic address: hazhar.i.karim@gmail.com.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2013 Nov 15;939:80-5. doi: 10.1016/j.jchromb.2013.08.036. Epub 2013 Sep 14.
Thiopurine efficacy is partly reflected by the genetic polymorphism of the thiopurine methyltransferase (TPMT) enzyme, which is responsible for variation in the metabolism, toxicity and therapeutic efficacy of the thiopurines azathioprine (AZA), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG). Dete
PMID 24113235

Hot shot induction and reperfusion with a specific blocker of the es-ENT1 nucleoside transporter before and after hypothermic cardioplegia abolishes myocardial stunning in acutely ischemic hearts despite metabolic derangement: hot shot drug delivery before hypothermic cardioplegia.

Abd-Elfattah AS, Tuchy GE, Jessen ME, Salter DR, Goldstein JP, Brunsting LA 3rd, Wechsler AS.SourceCardiovascular Research Laboratories, Division of Cardiothoracic Surgery, Department of Surgery, VCU Medical Center, Richmond, Va. Electronic address: anwar@vcu.edu.
The Journal of thoracic and cardiovascular surgery.J Thorac Cardiovasc Surg.2013 Oct;146(4):961-970.e3. doi: 10.1016/j.jtcvs.2012.10.054. Epub 2013 Feb 17.
OBJECTIVE: Simultaneous inhibition of the cardiac equilibrative-p-nitrobenzylthioinosine (NBMPR)-sensitive (es) type of the equilibrative nucleoside transport 1 (ENT1) nucleoside transporter, with NBMPR, and adenosine deaminase, with erythro-9-[2-hydroxy-3-nonyl]adenine (EHNA), prevents release of m
PMID 23422047

The guinea pig atrial A1 adenosine receptor reserve for the direct negative inotropic effect of adenosine.

Kiss Z, Pak K, Zsuga J, Juhasz B, Varga B, Szentmiklosi AJ, Haines DD, Tosaki A, Gesztelyi R.SourceDepartment of Pharmacology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
General physiology and biophysics.Gen Physiol Biophys.2013 Sep;32(3):325-35. doi: 10.4149/gpb_2013041. Epub 2013 Jul 2.
Although the A1 adenosine receptor (A1 receptor), the main adenosine receptor type in cardiac muscle, is involved in powerful cardioprotective processes such as ischemic preconditioning, the atrial A1 receptor reserve has not yet been quantified for the direct negative inotropic effect of adenosine.
PMID 23817640

Cyclic ADP-Ribose Mediates Formyl Methionyl Leucyl Phenylalanine (fMLP)-Induced Intracellular Ca2+ Rise and Migration of Human Neutrophils

Morita Katsuya,Saida Minoru,Morioka Norimitsu,Kitayama Tomoya,Akagawa Yasumasa,Dohi Toshihiro
Journal of Pharmacological Sciences 106(3), 492-504, 2008
… and their inhibitors, inosine, uridine, and s-(4-nitrobenzyl)-6-thioinosine, reduced the [Ca2+]i rise induced by β-NAD+ and fMLP. …
NAID 130000075785

Application of HPLC to study the kinetics of a branched bi-enzyme system consisting of hypoxanthine-guanine phosphoribosyltransferase and xanthine oxidase-an important biochemical system to evaluate the efficiency of the anticancer drug 6-mercaptopurine in ALL cell line

KALRA Sukirti,PAUL Manash K.,BALARAM Hemalatha,MUKHOPADHYAY Anup Kumar
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 850(1), 7-14, 2007-05-01
NAID 10025797036

羽曾部正豪,実吉峯郎
魚病研究 20(2/3), 343-351, 1985
… In this report, we used five compounds such as 9-β-D-ribofuranosyl-6-mercaptopurine (6-thioinosine, 6-TI), 1-β-D-ribofuranosyl-5-hydroxyuracil (5-OHUrd), 1-β-D-ribofuranosyl-1, 2, 4-triazole-3-carboxamide (Virazole), 9-[S]-(2, 3-dihydroxypropyl)adenine ([S]-DHPA) and 7-chloro-4(4-diethylamino-1-methyl-butylamino)-quinoline (Chloroquine).<BR> …
NAID 130000858878