WordNet

a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia (同)Purinethol

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Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2.

Shimada T1,2, Nakanishi T2, Tajima H3, Yamazaki M1, Yokono R1, Takabayashi M1, Shimada T1, Sawamoto K1, Miyamoto K1, Kitagawa H3, Ohta T3, Tamai I2, Sai Y1.
Journal of pharmaceutical sciences.J Pharm Sci.2015 Sep;104(9):3162-9. doi: 10.1002/jps.24498. Epub 2015 Jun 2.
Hepatic arterial infusion (HAI) chemotherapy with gemcitabine (GEM) is expected to be more effective and safer method to treat hepatic metastasis of pancreatic cancer compared with intravenous administration, because it affords higher tumor exposure with lower systemic exposure. Thus, a key issue fo
PMID 26037416

Liquid Chromatography with Amperometric Detection at a Silver Based Detector for the Determination of Thiocompounds: Application to the Assay of Thiopurine Antimetabolites in Urine.

Karadas-Bakirhan N1, Sarakbi A2, Vandeput M2, Ozkan SA1, Kauffmann JM2.
Analytical chemistry.Anal Chem.2015 Jul 7;87(13):6730-5. doi: 10.1021/acs.analchem.5b00879. Epub 2015 Jun 22.
A silver amperometric detector coupled to liquid chromatography (LC) was used for the determination of 6-thioguanine (6-TG) and two of its metabolites, thiouric acid (TU) and 2-amino-6-mercaptopurine riboside (6-TGR). The silver detector coupled to LC operated at a low applied potential (0.08 V vs A
PMID 26024436

Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish.

Siebel AM1, Menezes FP, Capiotti KM, Kist LW, da Costa Schaefer I, Frantz JZ, Bogo MR, Da Silva RS, Bonan CD.
Zebrafish.Zebrafish.2015 Apr;12(2):127-36. doi: 10.1089/zeb.2014.1004. Epub 2015 Jan 5.
Adenosine is a well-known endogenous modulator of neuronal excitability with anticonvulsant properties. Thus, the modulation exerted by adenosine might be an effective tool to control seizures. In this study, we investigated the effects of drugs that are able to modulate adenosinergic signaling on p
PMID 25560904

馬渡英夫,UNEI KAZUHIKO,NISHIMURA SHIN-ICHIRO,SAKURA NOBUO,UEDA KAZUHIRO
Pediatrics international : official journal of the Japan Pediatric Society 43(6), 673-677, 2001-12-01
NAID 10010092973

Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside, Evidence for involvement of amp-activated protein kinase

Augmentation of Tumor Immunity by 6-Mercaptopurine (6-MP) and Its Analogs in the Double Grafted Tumor System in Mice

樫田龍雄,奈良崎直子,酒井敦子,辻原健二,黒葛原啓,竹山茂之
Biological & pharmaceutical bulletin 18(11), 1492-1497, 1995-11-15
… We investigated the antitumor effect of 6-mercaptopurine (6-MP) and its analogs using the double grafted tumor technique. …
NAID 110003663303