マレイン酸チエチルペラジン

関: thiethylperazine、thiethylperazine malate

WordNet

a salt or ester of maleic acid; used as a nontricyclic antidepressant drug for psychomotor activation

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/10 11:38:31」(JST)

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Thiethylperazine (Torecan) is an antiemetic of the phenothiazine class. Though it was never licensed or used as an antipsychotic, it may have such effects.

Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice. ^[1]

References

^ Science Daily (September 1, 2011). "Alzheimer Disease: Transport Protein ABCC1 Plays Key Role in Clearing Beta-Amyloid from Brains of Mice.". Retrieved September 1, 2011.

Bourquin, J. P.; Schwarb, G.; Gamboni, G.; Rischer, R.; Ruesch, L.; Uldimann, S. G.; Theuss, U.; Schenke, E.; Renz, J.; Helv. Chim. Acta 1958, 41, 1072.

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1. 制吐剤の特性 characteristics of antiemetic drugs
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5. 妊娠中絶の概要 overview of pregnancy termination

English Journal

[Noncardiogenic pulmonary edema in the course of poisoning with clozapine, ketoprofen and thiethylperazine].

Majewska M1, Kołodziej M, Szponar J, Drelich G, Danielewicz P, Kostek H.
Przeglad lekarski.Przegl Lek.2012;69(8):618-20.
Pulmonary edema is a severe, potentially fatal clinical condition. It happens, when interstitial fluid is accumulating in the alveoli, impeding proper gas exchange. Typically we distinguish cardiogenic and noncardiogenic pulmonary edema. The article describes the case of severe pulmonary edema, whic
PMID 23243946

Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice.

Krohn M1, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, Schumacher T, Brüning T, Plath AS, Alfen F, Schmidt A, Winter F, Rateitschak K, Wree A, Gsponer J, Walker LC, Pahnke J.
The Journal of clinical investigation.J Clin Invest.2011 Oct;121(10):3924-31. doi: 10.1172/JCI57867. Epub 2011 Sep 1.
In Alzheimer disease (AD), the intracerebral accumulation of amyloid-β (Aβ) peptides is a critical yet poorly understood process. Aβ clearance via the blood-brain barrier is reduced by approximately 30% in AD patients, but the underlying mechanisms remain elusive. ABC transporters have been impli
PMID 21881209

Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro.

Rahbar M1, Mehrgan H, Hadji-nejad S.
Basic & clinical pharmacology & toxicology.Basic Clin Pharmacol Toxicol.2010 Aug;107(2):676-9. doi: 10.1111/j.1742-7843.2010.00558.x. Epub 2010 Mar 28.
The antimicrobial and resistance-reversal activities of seven phenothiazine derivatives were evaluated against vancomycin-sensitive Enterococcus faecalis ATCC 29212, vancomycin resistant E. faecalis ATCC 51299 and ten vancomycin-resistant E. faecium strains originating from human infections. Minimum
PMID 20353486

Japanese Journal

妊娠ダイコクネズミへのthiethylperazine-maleateによる胎仔における異所的癒合症

内山安男,間藤方雄
医学と生物学 91(3), p159-162, 1975-09
NAID 40000109189

妊娠悪阻に対するThiethylperazine maleate"Toresten"の治療効果について

高知床志 [他]
産科と婦人科 33(12), 1799-1801, 1966-12
NAID 40017815656

妊娠動物に投与されたThiethylperazine maleateの胎仔並に新生仔に及ぼす影響

渡辺和夫
産婦人科の進歩 17(3), 119-128, 1965-05
NAID 40017831903

「チエチルペラジン」

Thiethylperazine
Systematic (IUPAC) name
	2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Protein binding	60%
Identifiers
CAS number	1420-55-9
ATC code	R06AD03
PubChem	CID 5440
DrugBank	DB00372
ChemSpider	5245
UNII	8ETK1WAF6R
KEGG	D02354
ChEBI	CHEBI:9544
ChEMBL	CHEMBL1378
Chemical data
Formula	C22H29N3S2
Mol. mass	399.618 g/mol
	SMILES S(c2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(C)CC4)CC;
	InChI InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3 ; Key:XCTYLCDETUVOIP-UHFFFAOYSA-N ;
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英: thiethylperazine、thiethylperazine malate、thiethylperazine maleate
関: リンゴ酸チエチルペラジン、マレイン酸チエチルペラジン

「thiethylperazine malate」

　　[★]

リンゴ酸チエチルペラジン

関: thiethylperazine、thiethylperazine maleate

「マレイン酸チエチルペラジン」

　　[★]

英: thiethylperazine maleate
関: チエチルペラジン

「maleate」

　　[★]

マレイン酸、マレイン酸塩、マレイン酸エステル

関: maleic acid

maleic acid

「thiethylperazine」

　　[★]

チエチルペラジン

関: thiethylperazine malate、thiethylperazine maleate

[1] Science Daily (September 1, 2011). "Alzheimer Disease: Transport Protein ABCC1 Plays Key Role in Clearing Beta-Amyloid from Brains of Mice.". Retrieved September 1, 2011.

リンク元	「チエチルペラジン」「thiethylperazine malate」「マレイン酸チエチルペラジン」
関連記事	「maleate」「thiethylperazine」

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thiethylperazine maleate