チアミンピロホスホキナーゼ
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/13 10:04:41」(JST)
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| thiamin diphosphokinase |
| Identifiers |
| EC number |
2.7.6.2 |
| CAS number |
9026-24-8 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
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In enzymology, a thiamine diphosphokinase (EC 2.7.6.2) is an enzyme that catalyzes the chemical reaction
- ATP + thiamine AMP + thiamine diphosphate
Thus, the two substrates of this enzyme are ATP and thiamine, whereas its two products are AMP and thiamine diphosphate.
This enzyme belongs to the family of transferases, specifically those transferring two phosphorus-containing groups (diphosphotransferases). The systematic name of this enzyme class is ATP:thiamine diphosphotransferase. Other names in common use include thiamin kinase, thiamine pyrophosphokinase, ATP:thiamin pyrophosphotransferase, thiamin pyrophosphokinase, thiamin pyrophosphotransferase, thiaminokinase, thiamin:ATP pyrophosphotransferase, and TPTase. This enzyme participates in thiamine metabolism.
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1IG0, 1IG3, 2F17, 2G9Z, 2HH9, and 2OMK.
References
- Leuthardt F and Nielsen H (1952). "Phosphorylation biologique de la thiamine". Helv. Chim. Acta 35 (4): 1196–1209. doi:10.1002/hlca.19520350415.
- Shimazono N, Mano Y, Tanaka R and Kajiro Y. "Mechanism of transpyrophosphorylation with thiamine pyrophosphokinase". J. (Tokyo). Biochem.: 959–961.
- Steyn-Parve EP (1952). "Partial purification and properties of thiaminokinase from yeast". Biochim. Biophys. Acta 8: 310–324. doi:10.1016/0006-3002(52)90046-2. PMID 14934742.
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Metabolism of vitamins, coenzymes, and cofactors
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| Fat soluble vitamins |
| Vitamin A |
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| Vitamin E |
- Alpha-tocopherol transfer protein
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| Vitamin D |
- liver (Sterol 27-hydroxylase or CYP27A1)
- renal (25-Hydroxyvitamin D3 1-alpha-hydroxylase or CYP27B1)
- degradation (1,25-Dihydroxyvitamin D3 24-hydroxylase or CYP24A1)
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| Vitamin K |
- Vitamin K epoxide reductase
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| Water soluble vitamins |
| Thiamine (B1) |
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| Niacin (B3) |
- Indoleamine 2,3-dioxygenase
- Formamidase
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| Pantothenic acid (B5) |
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| Folic acid (B9) |
- Dihydropteroate synthase
- Dihydrofolate reductase
- Serine hydroxymethyltransferase
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- Methylenetetrahydrofolate reductase
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| Vitamin B12 |
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| Vitamin C |
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| Riboflavin (B2) |
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| Nonvitamin cofactors |
| Tetrahydrobiopterin |
- GTP cyclohydrolase I
- 6-pyruvoyltetrahydropterin synthase
- Sepiapterin reductase
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| Molybdenum cofactor |
- MOCS1
- MOCS2
- MOCS3
- Gephyrin
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Transferases: phosphorus-containing groups (EC 2.7)
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2.7.1-2.7.4:
phosphotransferase/kinase
(PO4) |
| 2.7.1: OH acceptor |
- Hexo-
- Gluco-
- Fructo-
- Galacto-
- Phosphofructo-
- 1
- Liver
- Muscle
- Platelet
- 2
- Riboflavin
- Shikimate
- Thymidine
- NAD+
- Glycerol
- Pantothenate
- Mevalonate
- Pyruvate
- Deoxycytidine
- PFP
- Diacylglycerol
- Phosphoinositide 3
- Class I PI 3
- Class II PI 3
- Sphingosine
- Glucose-1,6-bisphosphate synthase
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| 2.7.2: COOH acceptor |
- Phosphoglycerate
- Aspartate kinase
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| 2.7.3: N acceptor |
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| 2.7.4: PO4 acceptor |
- Phosphomevalonate
- Adenylate
- Nucleoside-diphosphate
- Uridylate
- Guanylate
- Thiamine-diphosphate
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2.7.6: diphosphotransferase
(P2O7) |
- Ribose-phosphate diphosphokinase
- Thiamine diphosphokinase
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2.7.7: nucleotidyltransferase
(PO4-nucleoside) |
| Polymerase |
| DNA polymerase |
- DNA-directed DNA polymerase
- I
- II
- III
- IV
- V
- RNA-directed DNA polymerase
- Reverse transcriptase
- Telomerase
- DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase
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| RNA nucleotidyltransferase |
- RNA polymerase/DNA-directed RNA polymerase
- RNA polymerase I
- RNA polymerase II
- RNA polymerase III
- RNA polymerase IV
- Primase
- RNA-dependent RNA polymerase
- PNPase
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Phosphorolytic
3' to 5' exoribonuclease |
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| Nucleotidyltransferase |
- UTP—glucose-1-phosphate uridylyltransferase
- Galactose-1-phosphate uridylyltransferase
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| Guanylyltransferase |
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| Other |
- Recombinase (Integrase)
- Transposase
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| 2.7.8: miscellaneous |
| Phosphatidyltransferases |
- CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
- CDP-diacylglycerol—serine O-phosphatidyltransferase
- CDP-diacylglycerol—inositol 3-phosphatidyltransferase
- CDP-diacylglycerol—choline O-phosphatidyltransferase
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| Glycosyl-1-phosphotransferase |
- N-acetylglucosamine-1-phosphate transferase
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2.7.10-2.7.13: protein kinase
(PO4; protein acceptor) |
| 2.7.10: protein-tyrosine |
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| 2.7.11: protein-serine/threonine |
- see serine/threonine-specific protein kinases
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| 2.7.12: protein-dual-specificity |
- see serine/threonine-specific protein kinases
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| 2.7.13: protein-histidine |
- Protein-histidine pros-kinase
- Protein-histidine tele-kinase
- Histidine kinase
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Proteins: enzymes
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| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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| Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
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UpToDate Contents
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English Journal
- Construction of a thiamine pyrophosphate high-producing strain of Aspergillus oryzae by overexpression of three genes involved in thiamine biosynthesis.
- Tokui M, Kubodera T, Gomi K, Yamashita N, Nishimura A.SourceResearch and Development Department, Hakutsuru Sake Brewing Co. Ltd., Higashinada-ku, Kobe 658-0041, Japan. misato-tokui@hakutsuru.co.jp
- Journal of bioscience and bioengineering.J Biosci Bioeng.2011 Apr;111(4):388-90. Epub 2011 Jan 17.
- We have found a gene (thiP) encoding thiamine pyrophosphokinase (TPK) in the Aspergillus oryzae genome. No riboswitch-like region was found in the upstream region of thiP, although it was repressed probably by thiamine pyrophosphate (TPP) as well as thiA and nmtA, which are strictly regulated by TPP
- PMID 21247799
- A new crystal form of mouse thiamin pyrophosphokinase.
- Liu JY, Hurley TD.SourceDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- International journal of biochemistry and molecular biology.Int J Biochem Mol Biol.2011;2(2):111-8.
- Thiamin pyrophosphokinase (TPK) transfers a pyrophosphate group from ATP to the hydroxyl group of thiamin and produces thiamin pyrophosphate (TPP). TPP is the cofactor of metabolically important enzymes such as pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, branched-chain α-keto acid dehyd
- PMID 21552434
Japanese Journal
- Molecular Cloning and Analysis of the 5'-Flanking Region of the Human Thiamin Pyrophosphokinase Gene
- ONOZUKA Mari,KONNO Hiroyuki,AKAJI Kenichi,NISHINO Hoyoku,NOSAKA Kazuto
- Journal of nutritional science and vitaminology 51(4), 274-277, 2005-08
- … We cloned and analyzed the 5'-flanking region of the human thiamin pyrophosphokinase gene (hTPK1). …
- NAID 110002704076
- Steady-State Kinetics and Mutational Studies of Recombinant Human Thiamin Pyrophosphokinase
- ONOZUKA Mari,NOSAKA Kazuto
- Journal of nutritional science and vitaminology 49(3), 156-162, 2003-06-01
- NAID 50000264980
Related Links
- Thiamin pyrophosphokinase; Thiamine Pyrophosphokinase. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms ...
- GoPubMed lists recent and important papers and reviews for thiamin pyrophosphokinase 1(Thiamin Pyrophosphokinase) ... This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to ...
Related Pictures
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- 英
- thiamin pyrophosphokinase
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ビタミンB1、チアミン, thiamine