四塩化炭素中毒
WordNet
- the physiological state produced by a poison or other toxic substance (同)toxic condition, intoxication
- the act of giving poison to a person or animal with the intent to kill
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English Journal
- Protective effects of neohesperidin dihydrochalcone against carbon tetrachloride-induced oxidative damage in vivo and in vitro.
- Hu L1, Li L1, Xu D1, Xia X1, Pi R2, Xu D1, Wang W1, Du H1, Song E1, Song Y3.
- Chemico-biological interactions.Chem Biol Interact.2014 Apr 25;213:51-9. doi: 10.1016/j.cbi.2014.02.003. Epub 2014 Feb 14.
- The purpose of this study was to investigate the possible hepatoprotective effects of neohesperidin dihydrochalcone (NHDC) on carbon tetrachloride (CCl4)-induced acute oxidative injury in vivo and in vitro. In a mouse model, intraperitoneal injection of CCl4 resulted in a significant increase in ser
- PMID 24530446
- Opposing effects of prednisolone treatment on T/NKT cell- and hepatotoxin-mediated hepatitis in mice.
- Kwon HJ1, Won YS, Park O, Feng D, Gao B.
- Hepatology (Baltimore, Md.).Hepatology.2014 Mar;59(3):1094-106. doi: 10.1002/hep.26748. Epub 2014 Jan 21.
- Prednisolone is a corticosteroid that has been used to treat inflammatory liver diseases such as autoimmune hepatitis and alcoholic hepatitis. However, the results have been controversial, and how prednisolone affects liver disease progression remains unknown. In the current study we examined the ef
- PMID 24115096
- Protective effect of alcoholic extract of Entada pursaetha DC. against CCl4-induced hepatotoxicity in rats.
- Gupta G, More AS, Kumari RR, Lingaraju MC, Kumar D, Kumar D, Mishra SK, Tandan SK.
- Indian journal of experimental biology.Indian J Exp Biol.2014 Mar;52(3):207-14.
- The alcoholic extract of stem of E. pursaetha (PSE, 30, 100, 300 mg/kg body weight, po for 7 days) showed hepatoprotective activity against CCl4 (2 mL/kg body weight, ip)-induced hepatotoxicity. The extract exhibited a significant dose-dependent hepatoprotective effect comparable to standard drug si
- PMID 24669663
Related Links
- Encyclopedia article about Carbon tetrachloride poisoning. Information about Carbon tetrachloride poisoning in the Columbia Encyclopedia, Computer Desktop Encyclopedia, computing dictionary.
- A poisonous, nonflammable, colorless liquid, CCl4, used in fire extinguishers and as a dry-cleaning fluid. carbon tetrachloride. n. (Chemistry / Elements & Compounds) a colourless volatile nonflammable sparingly soluble liquid made from ...
★リンクテーブル★
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- 英
- carbon tetrachloride poisoning, carbon tetrachloride intoxication
- 同
- テトラクロロメタン中毒 tetrachloromethane poisoning
- 関
- 四塩化炭素、[[]]
病態生理
- 主に肝臓でP-450 mixed-function oxidaseによりCCl4がfree radicalであるCCl3・に変換される(BPT.19)
- 自己触媒的に膜のリン脂質を過酸化し、急激に小胞体を破壊する(BPT.19)
- 暴露から30分以内に肝臓の酵素やplasma proteinの合成が低下する(BPT.19)
- 2時間以内にsmooth ERが腫脹しSREからリボリボソームの解離が起こる(BPT.19)
- 肝細胞からの脂質の輸送が停止し脂肪肝を来す。これはアポプロテインの合成が停止するため(BPT.19)
USMLE