関: taurochenodeoxycholate

WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/04 00:54:57」(JST)

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Taurochenodeoxycholic acid is a bile acid formed in the liver of most species, including humans, by conjugation of chenodeoxycholic acid with taurine. It is secreted into bile and then into intestine. It is usually ionized at physiologic pH, although it can be crystallized as the sodium salt. It acts as detergent to solubilize fats in the small intestine and is itself absorbed by active transport in the terminal ileum. It is used as a cholagogue and choleretic.

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English Journal

Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations.

Mello-Vieira J, Sousa T, Coutinho A, Fedorov A, Lucas SD, Moreira R, Castro RE, Rodrigues CM, Prieto M, Fernandes F.SourceCentro de Química-Física Molecular and Institute of Nanoscience and Nanotechnology, IST, UTL, Lisbon, Portugal.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Sep;1828(9):2152-63. doi: 10.1016/j.bbamem.2013.05.021. Epub 2013 Jun 5.
Submillimolar concentrations of cytotoxic bile acids (BAs) induce cell death via apoptosis. On the other hand, several cytoprotective BAs were shown to prevent apoptosis in the same concentration range. Still, the mechanisms by which BAs trigger these opposite signaling effects remain unclear. This
PMID 23747364

Progressive stages of mitochondrial destruction caused by cell toxic bile salts.

Schulz S, Schmitt S, Wimmer R, Aichler M, Eisenhofer S, Lichtmannegger J, Eberhagen C, Artmann R, Tookos F, Walch A, Krappmann D, Brenner C, Rust C, Zischka H.SourceInstitute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Sep;1828(9):2121-33. doi: 10.1016/j.bbamem.2013.05.007. Epub 2013 May 17.
The cell-toxic bile salt glycochenodeoxycholic acid (GCDCA) and taurochenodeoxycholic acid (TCDCA) are responsible for hepatocyte demise in cholestatic liver diseases, while tauroursodeoxycholic acid (TUDCA) is regarded hepatoprotective. We demonstrate the direct mitochondrio-toxicity of bile salts
PMID 23685124

Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition.

Vaquero J, Monte MJ, Dominguez M, Muntané J, Marin JJ.SourceLaboratory of Experimental Hepatology and Drug Targeting (HEVEFARM), Biomedical Research Institute of Salamanca (IBSAL), University of Salamanca, Salamanca, Spain.
Biochemical pharmacology.Biochem Pharmacol.2013 Aug 6. pii: S0006-2952(13)00458-9. doi: 10.1016/j.bcp.2013.07.022. [Epub ahead of print]
The farnesoid X receptor (FXR) is a key sensor in bile acid homeostasis. Although four human FXR isoforms have been identified, the physiological role of this diversity is poorly understood. Here we investigated their subcellular localization, agonist sensitivity and response of target genes. Measur
PMID 23928191

Japanese Journal

Antibacterial Drug Treatment Increases Intestinal Bile Acid Absorption via Elevated Levels of Ileal Apical Sodium-Dependent Bile Acid Transporter but Not Organic Solute Transporter α Protein

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Biological and Pharmaceutical Bulletin 38(3), 493-496, 2015
… Antibacterial drug treatment increases the bile acid pool size and hepatic bile acid concentration through the elevation of hepatic bile acid synthesis. … However, the involvement of intestinal bile acid absorption in the increased bile acid pool size remains unclear. …
NAID 130004872272

Antibacterial drug treatment increases intestinal bile acid absorption via elevated levels of ileal apical sodium-dependent bile acid transporter but not organic solute transporter α protein

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Biological and Pharmaceutical Bulletin advpub(0), 2014
… Antibacterial drug treatment increases the bile acid pool size and hepatic bile acid concentration through the elevation of hepatic bile acid synthesis. … However, the involvement of intestinal bile acid absorption in the increased bile acid pool size remains unclear. …
NAID 130004872289

Strain Differences in Deconjugation of Bile Acids in Bifidobacterium pseudocatenulatum Isolates

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Bioscience and microflora 23(2), 93-98, 2004-04-01
… Six isolates of bifidobacteria with higher tolerance to 4.0% of bile were further evaluated for their ability to deconjugate different types of bile acids namely taurocholic acid (TC), glycocholic acid (GC), taurochenodeoxycholic acid (TCDC), glycochenodeoxycholic acid (GCDC), taurodeoxycholic acid (TDC), and glycodeoxycholic acid (GDC). …
NAID 10027995027

「taurochenodeoxycholate」

Taurochenodeoxycholic acid
Names
	IUPAC name -[4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid
	Other names 12-Deoxycholyltaurine; 12-Desoxycholyltaurine; Chenodeoxycholyltaurine; Chenyltaurine
Identifiers
CAS Number	516-35-8
ChEBI	CHEBI:16525
ChEMBL	ChEMBL185878
ChemSpider	343282
IUPHAR/BPS	4747
Jmol 3D model	Interactive image
PubChem	387316
	InChI InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 Key: BHTRKEVKTKCXOH-BJLOMENOSA-N ; InChI=1/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 Key: BHTRKEVKTKCXOH-BJLOMENOBE ;
	SMILES O=S(=O)(O)CCNC(=O)CC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]4[C@H]2[C@H](O)C[C@@H]3C[C@H](O)CC[C@@]34C)C ;
Properties
Chemical formula	C26H45NO6S
Molar mass	499.71 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references