taurochenodeoxycholate

タウロケノデオキシコール酸

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taurochenodeoxycholic acid

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/12 11:51:04」(JST)

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Taurochenodeoxycholic acid
IUPAC name -[4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid
Other names 12-Deoxycholyltaurine; 12-Desoxycholyltaurine; Chenodeoxycholyltaurine; Chenyltaurine
Identifiers
CAS number	516-35-8 N
PubChem	387316
ChemSpider	343282 Y
ChEBI	CHEBI:16525 Y
ChEMBL	CHEMBL185878 Y
Jmol-3D images	Image 1
SMILES O=S(=O)(O)CCNC(=O)CC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]4[C@H]2[C@H](O)C[C@@H]3C[C@H](O)CC[C@@]34C)C
InChI InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 Y Key: BHTRKEVKTKCXOH-BJLOMENOSA-N Y InChI=1/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 Key: BHTRKEVKTKCXOH-BJLOMENOBE
Properties
Molecular formula	C26H45NO6S
Molar mass	499.70 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
N (verify) (what is: Y/N?)
Infobox references

Taurochenodeoxycholic acid is a bile acidformed in the liver by conjugation of chenodeoxycholate with taurine, usually as the sodium salt. It acts as detergent to solubilise fats in the small intestine and is itself absorbed. It is used as a cholagogue and choleretic.

See also

• Tauroursodeoxycholic acid, an epimer

English Journal

• Primary bile acids as potential biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy.

• Chen J, Deng W, Wang J, Shao Y, Ou M, Ding M.SourceKey Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing Medical University, Chongqing, China.
• International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.Int J Gynaecol Obstet.2013 Apr 4. pii: S0020-7292(13)00133-1. doi: 10.1016/j.ijgo.2013.02.015. [Epub ahead of print]
• OBJECTIVE: To identify possible biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy (ICP) through serum bile acid (SBA) profiling in women with ICP.METHODS: Serum samples were collected in the last trimester of pregnancy from 33 women with severe ICP, 28 women with mild ICP,
• PMID 23562588

• Taurochenodeoxycholic acid induces apoptosis of fibroblast-like synoviocytes.

• Li L, Liu C, Liu M, Shi L, Liu Q, Guan H, Li P.SourceKey Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
• European journal of pharmacology.Eur J Pharmacol.2013 Mar 16;706(1-3):36-40. doi: 10.1016/j.ejphar.2013.02.051. [Epub ahead of print]
• Recent evidences have suggested that the paucity of the apoptosis of fibroblast-like synoviocytes (FLS) may contribute to the pathogenesis of rheumatoid arthritis. Apoptosis induction of rheumatoid arthritis FLS is therefore suggested as a potential therapeutic approach for rheumatoid arthritis. Tau
• PMID 23510744

• Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo.

• Liang B, Wang S, Wang Q, Zhang W, Viollet B, Zhu Y, Zou MH.SourceSection of Molecular Medicine, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
• Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2013 Mar;33(3):595-604. doi: 10.1161/ATVBAHA.112.300606. Epub 2013 Jan 3.
• OBJECTIVE: The endoplasmic reticulum (ER) plays a critical role in ensuring proper folding of newly synthesized proteins. Aberrant ER stress is reported to play a causal role in cardiovascular diseases. However, the effects of ER stress on vascular smooth muscle contractility and blood pressure rema
• PMID 23288166

Japanese Journal

• Inhibition of Hepatocyte Growth Factor Production in Human Fibroblasts by Ursodeoxycholic Acid(Pharmacology)

• Hiramatsu Kaori,Matsumoto Yohsuke,Miyazaki Masahiro [他],TSUBOUCHI Hirohito,YAMAMOTO Itaru,GOHDA Eiichi
• Biological & pharmaceutical bulletin 28(4), 619-624, 2005-04-01
• … Deoxycholate, chenodeoxycholate, taurochenodeoxycholate and glycochenodeoxycholate also inhibited cholera-toxin-induced HGF production at non-cytotoxic doses. …
• NAID 10016661983

• Injuriousness of glycochenodeoxycholate and taurochenodeoxycholare to cultured hepatocytes

• NOTO Hiromitsu,MATSUSHITA Michiaki,NISHIKAWA Makoto,OKUBO Hisashi,KAMACHI Hirofumi,NISHIKAWA Kazutaka,FUJIMOTO Tetsuya,TODO Satoru
• Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 5(1), 30-36, 2002-03-01
• NAID 10011164513

• The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade

• RUST C
• J Biol Chem 275, 20210-20216, 2000
• NAID 80011767833

Related Links

• taurochenodeoxycholate (CHEBI:9407) - EMBL European ...

Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds. ... ChEBI The database and ontology of Chemical Entities of Biological Interest

• taurochenodeoxycholate: Definition from Answers.com

taurochenodeoxycholate the anionic form of the amido conjugate of taurine and chenodeoxycholate . It is a major bile acid ... Oxford Dictionary of Biochemistry: taurochenodeoxycholate Top Home > Library > Science > Biochemistry ...

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taurochenodeoxycholate

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taurochenodeoxycholic acid、taurochenodeoxycholate