Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/12 11:51:04」(JST)

English Journal

Primary bile acids as potential biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy.

Chen J, Deng W, Wang J, Shao Y, Ou M, Ding M.SourceKey Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing Medical University, Chongqing, China.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.Int J Gynaecol Obstet.2013 Apr 4. pii: S0020-7292(13)00133-1. doi: 10.1016/j.ijgo.2013.02.015. [Epub ahead of print]
OBJECTIVE: To identify possible biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy (ICP) through serum bile acid (SBA) profiling in women with ICP.METHODS: Serum samples were collected in the last trimester of pregnancy from 33 women with severe ICP, 28 women with mild ICP,
PMID 23562588

Li L, Liu C, Liu M, Shi L, Liu Q, Guan H, Li P.SourceKey Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
European journal of pharmacology.Eur J Pharmacol.2013 Mar 16;706(1-3):36-40. doi: 10.1016/j.ejphar.2013.02.051. [Epub ahead of print]
Recent evidences have suggested that the paucity of the apoptosis of fibroblast-like synoviocytes (FLS) may contribute to the pathogenesis of rheumatoid arthritis. Apoptosis induction of rheumatoid arthritis FLS is therefore suggested as a potential therapeutic approach for rheumatoid arthritis. Tau
PMID 23510744

Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo.

Liang B, Wang S, Wang Q, Zhang W, Viollet B, Zhu Y, Zou MH.SourceSection of Molecular Medicine, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA.
Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2013 Mar;33(3):595-604. doi: 10.1161/ATVBAHA.112.300606. Epub 2013 Jan 3.
OBJECTIVE: The endoplasmic reticulum (ER) plays a critical role in ensuring proper folding of newly synthesized proteins. Aberrant ER stress is reported to play a causal role in cardiovascular diseases. However, the effects of ER stress on vascular smooth muscle contractility and blood pressure rema
PMID 23288166

Inhibition of Hepatocyte Growth Factor Production in Human Fibroblasts by Ursodeoxycholic Acid(Pharmacology)

Hiramatsu Kaori,Matsumoto Yohsuke,Miyazaki Masahiro [他],TSUBOUCHI Hirohito,YAMAMOTO Itaru,GOHDA Eiichi
Biological & pharmaceutical bulletin 28(4), 619-624, 2005-04-01
… Deoxycholate, chenodeoxycholate, taurochenodeoxycholate and glycochenodeoxycholate also inhibited cholera-toxin-induced HGF production at non-cytotoxic doses. …
NAID 10016661983

Injuriousness of glycochenodeoxycholate and taurochenodeoxycholare to cultured hepatocytes

NOTO Hiromitsu,MATSUSHITA Michiaki,NISHIKAWA Makoto,OKUBO Hisashi,KAMACHI Hirofumi,NISHIKAWA Kazutaka,FUJIMOTO Tetsuya,TODO Satoru
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 5(1), 30-36, 2002-03-01
NAID 10011164513

The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade

リンク元	「taurochenodeoxycholic acid」「タウロケノデオキシコール酸」

Taurochenodeoxycholic acid
	IUPAC name -[4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid
	Other names 12-Deoxycholyltaurine; 12-Desoxycholyltaurine; Chenodeoxycholyltaurine; Chenyltaurine
Identifiers
CAS number	516-35-8
PubChem	387316
ChemSpider	343282
ChEBI	CHEBI:16525
ChEMBL	CHEMBL185878
Jmol-3D images	Image 1
	SMILES O=S(=O)(O)CCNC(=O)CC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]4[C@H]2[C@H](O)C[C@@H]3C[C@H](O)CC[C@@]34C)C ;
	InChI InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 ; Key: BHTRKEVKTKCXOH-BJLOMENOSA-N InChI=1/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1; Key: BHTRKEVKTKCXOH-BJLOMENOBE ;
Properties
Molecular formula	C26H45NO6S
Molar mass	499.70 g mol−1
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	(verify) (what is: /?)
	Infobox references