WordNet

systematic combining of root and modifying elements into single words
a compound made artificially by chemical reactions (同)synthetic substance
involving or of the nature of synthesis (combining separate elements to form a coherent whole) as opposed to analysis; "limnology is essentially a synthetic science composed of elements...that extend well beyond the limits of biology"- P.S.Welch (同)synthetical
of a proposition whose truth value is determined by observation or facts; "`all men are arrogant is a synthetic proposition" (同)synthetical
not genuine or natural; "counterfeit rhetoric that flourishes when passions are synthetic"- George Will
male sex hormone that is produced in the testes and responsible for typical male sexual characteristics (同)androgenic_hormone

PrepTutorEJDIC

総合の,統合的な / 合成の,人造の / にせの,作りごとの / (言語が)総合的な(統語的関係を表すのに,独立した語より屈折形を広く用いるもの) / 合成品,人造物
アンドロゲン(男性ホルモン)

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1. 女性におけるアンドロゲン欠乏症および治療の概要 overview of androgen deficiency and therapy in women
2. アスリートにおけるアンドロゲンおよびその他のホルモンの使用 use of androgens and other hormones by athletes
3. アンドロゲン受容体障害の診断および治療 diagnosis and treatment of disorders of the androgen receptor
4. 播種性前立腺癌に対する治療の概要 overview of the treatment of disseminated prostate cancer
5. 副腎アンドロゲンの測定 measurement of adrenal androgens

English Journal

Docking and CoMSIA studies on steroids and non-steroidal chemicals as androgen receptor ligands.

Wang X, Li X, Shi W, Wei S, Giesy JP, Yu H, Wang Y.SourceState Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210046, People's Republic of China.
Ecotoxicology and environmental safety.Ecotoxicol Environ Saf.2013 Mar;89:143-9. doi: 10.1016/j.ecoenv.2012.11.020. Epub 2012 Dec 20.
While some synthetic chemicals have been demonstrated to disrupt normal endocrine function by binding to the androgen receptor (AR), the mechanism by which ligands bind to the ligand binding domain (LBD) remained unclear. In this study, docking and comparative molecular similarity index analysis (Co
PMID 23260236

Development of Potent and Selective Indomethacin Analogs for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer.

Liedtke AJ, Adeniji AO, Chen M, Byrns MC, Jin Y, Christianson DW, Marnett LJ, Penning TM.AbstractCastrate-resistant prostate cancer (CRPC) is a fatal, metastatic form of prostate cancer. CRPC is characterized by reactivation of the androgen axis due to changes in androgen receptor signaling and/or adaptive intratumoral androgen biosynthesis. AKR1C3 is upregulated in CRPC where it catalyzes the formation of potent androgens. This makes AKR1C3 a target for the treatment of CRPC. AKR1C3 inhibitors should not inhibit AKR1C1/AKR1C2, which inactivate 5α-dihydrotestosterone. Indomethacin, used to inhibit cyclooxygenase, also inhibits AKR1C3 and displays selectivity over AKR1C1/AKR1C2. Parallel synthetic strategies were used to generate libraries of indomethacin analogs, which exhibit reduced cyclooxygenase inhibitory activity but retain AKR1C3 inhibitory potency and selectivity. The lead compounds inhibited AKR1C3 with nanomolar potency, displayed >100-fold selectivity over AKR1C1/AKR1C2, and blocked testosterone formation in LNCaP-AKR1C3 cells. The AKR1C3•NADP(+) •2'-des-methyl-indomethacin crystal structure was determined and it revealed a unique inhibitor binding mode. The compounds reported are promising agents for the development of therapeutics for CRPC.
Journal of medicinal chemistry.J Med Chem.2013 Feb 22. [Epub ahead of print]
Castrate-resistant prostate cancer (CRPC) is a fatal, metastatic form of prostate cancer. CRPC is characterized by reactivation of the androgen axis due to changes in androgen receptor signaling and/or adaptive intratumoral androgen biosynthesis. AKR1C3 is upregulated in CRPC where it catalyzes the
PMID 23432095

The Synthetic Progestin Levonorgestrel Is a Potent Androgen in the Three-Spined Stickleback (Gasterosteus aculeatus).

Svensson J, Fick J, Brandt I, Brunström B.SourceDepartment of Environmental Toxicology, Uppsala University , Norbyvägen 18A, SE-75 236 Uppsala, Sweden.
Environmental science & technology.Environ Sci Technol.2013 Feb 19;47(4):2043-51. doi: 10.1021/es304305k. Epub 2013 Feb 11.
The use of progestins has resulted in contamination of aquatic environments and some progestins have in experimental studies been shown to impair reproduction in fish and amphibians at low ng L(-1) concentrations. The mechanisms underlying their reproductive toxicity are largely unknown. Some proges
PMID 23362984

Japanese Journal

去勢抵抗性前立腺がんの緩和医療における合成グルココルチコイドの有用性と有害性

茅根義和,井上重治
日本緩和医療薬学雑誌 5(2), 19-29, 2012-06
NAID 40019405965

Androgen Receptor Antagonists and Anti-prostate Cancer Activities of Some Synthesized Steroidal Candidates

, , [他], , ,
Chemical and Pharmaceutical Bulletin 59(11), 1363-1368, 2011
… In continuation of our previous work, a novel series of steroid derivatives were synthesized and their androgen receptor (AR) antagonist activities and in vivo antiandrogenic properties were evaluated. … Synthetic steroidal structures fused to a substituted cyanopyrane ring seem to be a promising approach in the search for novel leads for potent antagonistic, antiandrogen and prostate anticancer agents. …
NAID 130001274811

In vitro study of Organization for Economic Co-operation and Development (OECD) endocrine disruptor screening and testing methods- establishment of a recombinant rat androgen receptor (rrAR) binding assay

, , [他], , , , , ,
Journal of toxicological sciences 35(2), 239-243, 2010-04-01
… The androgen receptor (AR) binding assay can be used to determine the ability of probable endocrine disruptors (EDs) to compete with synthetic androgen methyltrienolone (R1881) for binding to recombinant rat AR (rrAR). …
NAID 10026193468