WordNet

capable of being surmounted or overcome; "situations of measurable and surmountable danger"
capable of being surmounted (同)climbable
not capable of being surmounted or overcome; "insurmountable disadvantages" (同)unsurmountable
incapable of being surmounted or climbed (同)unclimbable

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Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya.

Hodgson SH1, Juma E2,3, Salim A4, Magiri C5, Njenga D6, Molyneux S7, Njuguna P8, Awuondo K9, Lowe B10, Billingsley PF11, Cole AO12,13, Ogwang C14, Osier F15, Chilengi R16, Hoffman SL17, Draper SJ18, Ogutu B19,20, Marsh K21.
Malaria journal.Malar J.2015 Apr 28;14(1):182. doi: 10.1186/s12936-015-0671-x.
BACKGROUND: Controlled human malaria infection (CHMI) studies, in which healthy volunteers are infected with Plasmodium falciparum to assess the efficacy of novel malaria vaccines and drugs, have become a vital tool to accelerate vaccine and drug development. CHMI studies provide a cost-effective an
PMID 25927522

"Why should I take drugs for your infection?": outcomes of formative research on the use of HIV pre-exposure prophylaxis in Nigeria.

Idoko J1, Folayan MO2,3,4, Dadem NY5, Kolawole GO6, Anenih J7, Alhassan E8.
BMC public health.BMC Public Health.2015 Apr 10;15(1):349. [Epub ahead of print]
BACKGROUND: Nigeria has the second highest number of new HIV infections annually. Therefore, it is important to explore new strategies for preventing new infections. The introduction of pre-exposure prophylaxis (PrEP) for use by persons at high risk of HIV infection has new potential in preventing n
PMID 25881087

Broad J1, Callaghan B2, Sanger GJ3, Brock JA2, Furness JB2.
European journal of pharmacology.Eur J Pharmacol.2015 Apr 5;752:34-9. doi: 10.1016/j.ejphar.2015.02.005. Epub 2015 Feb 14.
Ulimorelin (TZP101) is a ghrelin receptor agonist that stimulates intestinal motility, but also reduces blood pressure in rodents and humans and dilates blood vessels. It has been proposed as a treatment for intestinal motility disorders. Here we investigated the mechanisms through which ulimorelin
PMID 25687251

A G protein-coupled receptor dimer imaging assay reveals selectively modified pharmacology of neuropeptide Y Y1/Y5 receptor heterodimers.

Kilpatrick LE1, Humphrys LJ1, Holliday ND2.
Molecular pharmacology.Mol Pharmacol.2015 Apr;87(4):718-32. doi: 10.1124/mol.114.095356. Epub 2015 Jan 30.
The ability of G protein-coupled receptors (GPCRs) to form dimers, and particularly heterodimers, offers potential for targeted therapeutics with improved selectivity. However, studying dimer pharmacology is challenging, because of signaling cross-talk or because dimerization may often be transient
PMID 25637604

近藤大生
大阪青山大学紀要 5, 31-52, 2012
… As result, I reached the conclusion that there exists a hardly surmountable organizational barrier, which forms the basis of differences in the way of thinking and sense of values between the two camps. …
NAID 120005345128

和田正義,坂田聡士,森村篤,矢嶋浩幸
ロボティクス・メカトロニクス講演会講演概要集 2006, "2P2-E16(1)"-"2P2-E16(2)", 2006
… To estimate and verify the enhanced mobility of a 4WD system, statics of a wheel-and-step system is analyzed and surmountable capabilities are tested in experiments not only for 4WD but also for a conventional rear-drive configuration. …
NAID 110008694410

Influence of pH on the Binding of Diphenylmethylenepiperidines by 5-HT_2B Receptors in Rat Stomach Fundus

稲田義行,仲建彦
日本薬理学雑誌 115(3), 151-160, 2000-03-01
… 者におけるtrough peak比からも確認されている.AII受容体拮抗薬の投与によりAII濃度は増加することが知られており, 上昇したAIIは受容体へ拮抗薬と競合し結合する.AII濃度が上昇した場合insurmountableな拮抗薬はsurmountableな拮抗薬よりもAIIの作用を効果的に抑制し, 有利に働くものと考えられる.多数の研究おいてカンデサルタンシレキセチルが降圧作用に加えて臓器保護作用を有することが示された.AT1受容体拮抗薬はACE阻害 …
NAID 10005705731

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