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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/29 15:50:50」(JST)

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Suprofen is a non-steroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica^[1] that was marketed as 1% eye drops under the trade name Profenal.

Uses

Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.^[2] It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.^[3] This application has been discontinued as well, at least in the US.^[4]

References

^ Janssen, Paul A.; Van Daele, Georges H. P.; Boey, Jozef M. "Antiphlogistic aroyl-substituted phenylacetic acid derivatives" (1974) DE 2353357
^ Nies A S (1988). "Renal effects of nonsteroidal anti-inflammatory drugs". Agents and actions 24: 95–106. doi:10.1007/978-3-0348-9160-8_9.
^ Guidance for FDA Staff and Industry Compliance Policy Guides Manual, Sec. 460.200
^ Drugs.com: suprofen ophthalmic

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English Journal

Nonsteroidal Anti-Inflammatory Drugs in the Treatment of Retinal Diseases.

Rodrigues EB, Farah ME, Bottós JM, Bom Aggio F.
Developments in ophthalmology.Dev Ophthalmol.2016;55:212-20. doi: 10.1159/000431197. Epub 2015 Oct 26.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are an important class of drugs in medicine and ophthalmology. Several NSAIDs have been commercially available for many years: diclofenac, flurbiprofen, indomethacin, ketorolac and suprofen. The purpose of this chapter is to review the clinical use of ea
PMID 26502088

Toxicity Originating from Thiophene Containing Drugs: Exploring the Mechanism using Quantum Chemical Methods.

Jaladanki CK1, Taxak N1, Varikoti RA1, Bharatam PV1.
Chemical research in toxicology.Chem Res Toxicol.2015 Dec 21;28(12):2364-76. doi: 10.1021/acs.chemrestox.5b00364. Epub 2015 Dec 10.
Drug metabolism of thiophene containing substrates by cytochrome P450s (CYP450) leads to toxic side effects, for example, nephrotoxicity (suprofen, ticlopidine), hepatotoxicity (tienilic acid), thrombotic thrombocytopenic purpura (clopidogrel), and aplastic anemia (ticlopidine). The origin of toxici
PMID 26574776

Separation and on-line preconcentration of nonsteroidal anti-inflammatory drugs by microemulsion electrokinetic chromatography.

Chang CW1, Chen YC1, Liu CY1.
Electrophoresis.Electrophoresis.2015 Aug 8. doi: 10.1002/elps.201500160. [Epub ahead of print]
The MEEKC separation and on-line preconcentration of nonsteroidal anti-inflammatory drugs (NSAIDs) were investigated. In this work, two microemulsion (ME) systems were employed. Complete separation could be achieved at a pH of 5.5 with octane as the oil phase (ME I). The LODs for the determination o
PMID 26257197

Japanese Journal

Two cases of photocontact dermatitis due to topical ketoprofen : Contrasting clinical appearance by different formulations

INUI Shigeki,DOI Toshiaki,SHIRAI Hirohiko,ITAMI Satoshi,YOSHIKAWA Kunihiko
Environmental dermatology : the official journal of the Japanese Society for Contact Dermatitis 10(2), 79-82, 2003-04-01
NAID 10013246320

Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen

O'DONNELL JP
Drug Metab Dispos. 31(11), 1369-1377, 2003
NAID 30003140277

Group study of the optimum concentrations of ketoprofen, tiaprofenic acid, suprofen and oxybenzone for the photopatch testing, and the patch test results of the Japanese Standard Allergens and gold sodium thiosulfate in 2000

KURIKAWA Yukiko,Research Group of the JSCD
Environmental dermatology : the official journal of the Japanese Society for Contact Dermatitis 9(2), 39-46, 2002-04-01
NAID 10013245903

Related Pictures

★リンクテーブル★

リンク元

「スプロフェン」

Systematic (IUPAC) name
	(RS)-2-[4-(2-thienylcarbonyl)phenyl]propanoic acid
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	C (US)
Legal status	Discontinued
Routes	Oral, eye drops
Pharmacokinetic data
Protein binding	20%
Identifiers
CAS number	40828-46-4
ATC code	M01AE07
PubChem	CID 5359
DrugBank	DB00870
ChemSpider	5166
UNII	988GU2F9PE
KEGG	D00452
ChEBI	CHEBI:9362
ChEMBL	CHEMBL956
Chemical data
Formula	C14H12O3S
Mol. mass	260.309 g/mol
	SMILES O=C(c1ccc(cc1)C(C(=O)O)C)c2sccc2;
	InChI InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17) ; Key:MDKGKXOCJGEUJW-UHFFFAOYSA-N ;
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英: suprofen
商: スルプロチン、スレンダム、トパルジック

プロピオン酸系非ステロイド性抗炎症薬

[1] Janssen, Paul A.; Van Daele, Georges H. P.; Boey, Jozef M. "Antiphlogistic aroyl-substituted phenylacetic acid derivatives" (1974) DE 2353357

[2] Nies A S (1988). "Renal effects of nonsteroidal anti-inflammatory drugs". Agents and actions 24: 95–106. doi:10.1007/978-3-0348-9160-8_9.

[3] Guidance for FDA Staff and Industry Compliance Policy Guides Manual, Sec. 460.200

[4] Drugs.com: suprofen ophthalmic

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suprofen