Gαi/o-coupled receptor-mediated sensitization of adenylyl cyclase: 40 years later.
Brust TF1, Conley JM1, Watts VJ2.
European journal of pharmacology.Eur J Pharmacol.2015 May 14. pii: S0014-2999(15)30013-3. doi: 10.1016/j.ejphar.2015.05.014. [Epub ahead of print]
Heterologous sensitization of adenylyl cyclase (also referred to as superactivation, sensitization, or supersensitization of adenylyl cyclase) is a cellular adaptive response first described 40 years ago in the laboratory of Dr. Marshall Nirenberg. This apparently paradoxical cellular response occur
Cannabinoid CB1 receptors activation and coactivation with D2 receptors modulate GABAergic neurotransmission in the globus pallidus and increase motor asymmetry.
Synapse (New York, N.Y.).Synapse.2015 Mar;69(3):103-14. doi: 10.1002/syn.21796. Epub 2014 Dec 23.
The cannabinoid CB1 (CB1R) and dopaminergic D2 (D2R) receptors modify GABAergic transmission in the globus pallidus. Although dopaminergic denervation produces changes in the expression and supersensitization of these receptors, the consequences of these changes on GABAergic neurotransmission are un
Biological psychiatry.Biol Psychiatry.2014 May 1;75(9):711-22. doi: 10.1016/j.biopsych.2013.05.006. Epub 2013 Jun 13.
BACKGROUND: L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia is an incapacitating complication of L-DOPA therapy that affects most patients with Parkinson's disease. Previous work indicating that molecular sensitization to dopamine receptor D1 (D1R) stimulation is involved in dyskinesias pro
the act or process of supersensitizing. This word doesn't usually appear in our free dictionary, but the definition from our premium Unabridged Dictionary is offered here on a limited basis. Note that some information is displayed differently in ...
PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. VIII. DISSOCIATION OF INDUCTION OF SUPERSENSITIVITY FROM PRESYNAPTIC ACTION OF COCAINE ON ISOLATED VAS DEFERENS OF GUINEA PIG. ARAKI KIYOSHI ...