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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/03 09:53:53」(JST)

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PARTICIPATION OF Y89 AND Y97 IN THE CONJUGATING ACTIVITY OF Drosophila melanogaster GLUTATHIONE S-TRANSFERASE D3 (DmGSTD3).

Vignesvaran K1, Alias Z1.
Archives of insect biochemistry and physiology.Arch Insect Biochem Physiol.2016 Jul;92(3):210-21. doi: 10.1002/arch.21332. Epub 2016 Apr 14.
Drosophila melanogaster glutathione S-transferase D3 (DmGSTD3) has a shorter amino acid sequence as compared to other GSTs known in the fruit flies. This is due to the 15 amino acid N-terminal truncation in which normally active amino acid residue is located. The work has made use of homology modeli
PMID 27075600

Oshida K1, Shimamura M2, Seya K3, Ando A1,2, Miyamoto Y4,5.
European journal of drug metabolism and pharmacokinetics.Eur J Drug Metab Pharmacokinet.2016 Mar 9. [Epub ahead of print]
BACKGROUND AND OBJECTIVE: Beraprost sodium (BPS) is a chemically stable and orally active prostacyclin analog that is used in the treatment of chronic arterial occlusive disease since 1992 and primary pulmonary hypertension since 1999 in Japan. Multiple-drug therapy is common in clinical practice, a
PMID 26961540

Investigation of Fluorescein Derivatives as Substrates of Organic Anion Transporting Polypeptide (OATP) 1B1 To Develop Sensitive Fluorescence-Based OATP1B1 Inhibition Assays.

Izumi S1, Nozaki Y1, Komori T1, Takenaka O2, Maeda K3, Kusuhara H3, Sugiyama Y4.
Molecular pharmaceutics.Mol Pharm.2016 Feb 1;13(2):438-48. doi: 10.1021/acs.molpharmaceut.5b00664. Epub 2016 Jan 7.
Organic anion transporting polypeptide (OATP) 1B1 plays an important role in the hepatic uptake of various drugs. Because OATP1B1 is a site of drug-drug interactions (DDIs), evaluating the inhibitory potential of drug candidates on OATP1B1 is required during drug development. For establishing a high
PMID 26696140

Rapid stimulating effect of the antiarrhythmic agent amiodarone on absorption of organic anion compounds

Segawa Masahiro,Ogura Jiro,Seki Satoru,Itagaki Shirou,Takahashi Natsuko,Kobayashi Masaki,Hirano Takeshi,Yamaguchi Hiroaki,Iseki Ken
Drug Metabolism and Pharmacokinetics, 2012
… AMD also increased the absorption of sulfobromophthalein (BSP), which is a typical organic anion compound, and the expression level of Oatp2b1 at the membrane in in vivo experiments. …
NAID 130004463301

Involvement of Specific Transport System on Uptake of Lactone Form of SN-38 in Human Intestinal Epithelial Cell Line Caco-2

Ueno Yusuke,Matsuda Hiroko,Mizutani Hideki [他],Iwamoto Takuya,Okuda Masahiro
Biological and Pharmaceutical Bulletin 35(1), 54-58, 2012
… In contrast, concomitant sulfobromophthalein, taurocholate and estrone 3-sulfate significantly increased SN-38L uptake. …
NAID 130001872342

Paclitaxel-resistance Conferred by Altered Expression of Efflux and Influx Transporters for Paclitaxel in the Human Hepatoma Cell Line, HepG2

TAKANO Mikihisa,OTANI Yoshifumi,TANDA Minori,KAWAMI Masashi,NAGAI Junya,YUMOTO Ryoko
Drug Metabolism and Pharmacokinetics 24(5), 418-427, 2009
… Sulfobromophthalein, an OATP1B3 inhibitor, inhibited [3H]paclitaxel uptake in HepG2 but not in PR-HepG2 cells. …
NAID 130004463091

リンク元	「ブロモスルホフタレインナトリウム」「スルホブロモフタレイン」
拡張検索	「sulfobromophthalein sodium」

Bromsulphthalein
Names
	IUPAC name disodium 2-hydroxy-5-[4,5,6,7-tetrabromo-1-(4-hydroxy-3-sulfonatophenyl)-3-oxo-1,3-dihydro-2-benzofuran-1-yl]benzene-1-sulfonate
Identifiers
CAS Number	71-67-0
ChEMBL	ChEMBL453904
ChemSpider	6046
	InChI InChI=1S/C20H10Br4O10S2.2Na/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;/q;2+1/p-2 Key: GHAFORRTMVIXHS-UHFFFAOYSA-L ; InChI=1/C20H10Br4O10S2.2Na/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;/q;2+1/p-2 Key: GHAFORRTMVIXHS-NUQVWONBAX ;
IUPHAR/BPS	4506
Jmol interactive 3D	Image
PubChem	6282
	SMILES [Na+].[Na+].[O-]S(=O)(=O)c1c(O)ccc(c1)C3(OC(=O)c2c(Br)c(Br)c(Br)c(Br)c23)c4ccc(O)c(c4)S([O-])(=O)=O ;
UNII	62E5JU30OV
Properties
Chemical formula	C20H8O10Br4S2Na2
Molar mass	838.00 g/mol
Pharmacology
ATC code	V04CE02
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references