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- 1. カンジダ性間擦疹 candidal intertrigo
- 2. 皮膚炎の概要 overview of dermatitis
- 3. 患者情報：脂漏性皮膚炎（フケ（頭部秕糠疹）および乳痂（乳幼児脂漏性皮膚炎）を含む）（詳細） seborrheic dermatitis including dandruff and cradle cap beyond the basics
English Journal
- Enantioselective Nano Liquid Chromatographic Separation of Racemic Pharmaceuticals: A Facile One-Pot In Situ Preparation of Lipase-Based Polymer Monoliths in Capillary Format.
- Ahmed M1, Ghanem A.Author information 1Chirality Program, Biomedical Science, University of Canberra, Australian Capital Territory (ACT), Australia.AbstractNew affinity monolithic capillary columns of 150 µm internal diameter were prepared in situ fused glass capillary via either immobilization or encapsulation of Candida antarctica lipase B (CALB) on or within polymer monoliths, respectively. The immobilized lipase-based monoliths were prepared via copolymerization of 19.1% monomers (8.9% MMA and 10.2% GMA), 19.8% EDMA, and 61.1% porogens (54.2% formamide and 6.9% 1-propanol) w/w or 20% GMA, 20% EDMA, and 60% porogens (51.6% cyclohexanol and 8.4% 1-dodecanol) in the presence of AIBN (1%) as a radical initiator. This was followed by pumping a solution of lipase through the capillaries and rinsing with potassium phosphate buffer. On the other hand, the encapsulated lipase-based monoliths were prepared via copolymerization of 20% monomers (GMA), 20% EDMA, and 60% porogens (48% 1-propanol, 6% 1,4-butanediol) or 16.4% monomers (16% BuMA, 0.4% SPMA), 23.6% EDMA, and 60% porogens (36% 1-propanol, 18% 1,4-butanediol along with 6% lipase aqueous solution in potassium phosphate buffer. The prepared capillary columns were investigated for the enantioselective nano liquid chromatographic separation of a set of different classes of racemic pharmaceuticals, namely, α- and β-blockers, antiinflammatory drugs, antifungal drugs, dopamine antagonists, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, diuretics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Run-to-run repeatability was quite satisfactory. The encapsulated lipase-based capillary monolith showed better enantioselective separations of most of the investigated compounds. Baseline separation was achieved for alprenolol, atenolol, bromoglutithimide, carbuterol, chloropheneramine, cizolertine carbinol, 4-hydroxy-3-methoxymandelic acid, desmethylcizolertine, nomifensine, normetanephrine, and sulconazole under reversed phase chromatographic conditions. A speculation about the understanding of the chiral recognition mechanism of lipase-based monoliths toward the investigated pharmaceuticals is discussed. Chirality 00:000-000, 2014. © 2014 Wiley Periodicals, Inc.
- Chirality.Chirality.2014 Mar 6. doi: 10.1002/chir.22290. [Epub ahead of print]
- New affinity monolithic capillary columns of 150 µm internal diameter were prepared in situ fused glass capillary via either immobilization or encapsulation of Candida antarctica lipase B (CALB) on or within polymer monoliths, respectively. The immobilized lipase-based monoliths were prepared via c
- PMID 24604679
- Investigation of chondroitin sulfate D and chondroitin sulfate E as novel chiral selectors in capillary electrophoresis.
- Zhang Q1, Du Y, Chen J, Xu G, Yu T, Hua X, Zhang J.Author information 1Department of Analytical Chemistry, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing, Jiangsu, 210009, China.AbstractVarious chiral selectors have been utilized successfully in capillary electrophoresis (CE); however, the number of polysaccharides used as chiral selectors is still small and the mechanism of enantiorecognition has not been fully elucidated. Chondroitin sulfate D (CSD) and chondroitin sulfate E (CSE), belonging to the group of glycosaminoglycans, are linear, sulfated polysaccharides with large mass. In this paper, they were investigated for the first time for their potential as chiral selectors by CE. The effect of buffer composition and pH, chiral selector concentration, and applied voltage were systematically examined and optimized. A variety of drug enantiomers were resolved in the buffer pH range of 2.8-3.4 using 20 mM Tris/H3PO4 buffer with 5.0 % CSD or CSE and 20 kV applied voltage. A central composite design was used to validate the optimized separation parameters and satisfactory uniformity was obtained. As observed, CSE allowed satisfactory separation of the enantiomers of amlodipine, laudanosine, nefopam, sulconazole, and tryptophan methyl ester, as well as partial resolution of citalopram, duloxetine, and propranolol under the optimized conditions. CSD allowed partial or nearly baseline separation of amlodipine, laudanosine, nefopam, and sulconazole. The results indicated that CSE has a better enantiorecognition capability than CSD toward the tested drugs.
- Analytical and bioanalytical chemistry.Anal Bioanal Chem.2014 Feb;406(5):1557-66. doi: 10.1007/s00216-013-7544-3. Epub 2013 Dec 21.
- Various chiral selectors have been utilized successfully in capillary electrophoresis (CE); however, the number of polysaccharides used as chiral selectors is still small and the mechanism of enantiorecognition has not been fully elucidated. Chondroitin sulfate D (CSD) and chondroitin sulfate E (CSE
- PMID 24363112
- The in vitro efficacy of antimicrobial agents against the pathogenic free-living amoeba Balamuthia mandrillaris.
- Ahmad AF1, Heaselgrave W, Andrew PW, Kilvington S.Author information 1Department of Infection, Immunity & Inflammation, University of Leicester, Maurice Shock Building, University Road, Leicester, LE1 9HN, United Kingdom; Department of Parasitology, Faculty of Medicine Building, University of Malaya, Kuala Lumpur, 50603, Malaysia.AbstractThe free-living amoeba Balamuthia mandrillaris causes usually fatal encephalitis in humans and animals. Only limited studies have investigated the efficacy of antimicrobial agents against the organism. Assay methods were developed to assess antimicrobial efficacy against both the trophozoite and cyst stage of B. mandrillaris (ATCC 50209). Amphotericin B, ciclopirox olamine, miltefosine, natamycin, paromomycin, pentamidine isethionate, protriptyline, spiramycin, sulconazole and telithromycin had limited activity with amoebacidal levels of > 135-500 μM. However, diminazene aceturate (Berenil(®) ) was amoebacidal at 7.8 μM and 31.3-61.5 μM for trophozoites and cysts, respectively. Assays for antimicrobial testing may improve the prognosis for infection and aid in the development of primary selective culture isolation media.
- The Journal of eukaryotic microbiology.J Eukaryot Microbiol.2013 Sep-Oct;60(5):539-43. doi: 10.1111/jeu.12062. Epub 2013 Jul 19.
- The free-living amoeba Balamuthia mandrillaris causes usually fatal encephalitis in humans and animals. Only limited studies have investigated the efficacy of antimicrobial agents against the organism. Assay methods were developed to assess antimicrobial efficacy against both the trophozoite and cys
- PMID 23869955
Japanese Journal
- 1%sulconazole nitrate ソリューションによる足白癬の治療経験
- 増谷衛
- 基礎と臨 26, 2682-2689, 1992
- NAID 80006543869
- Allergic contact dermatitis due to sulconazole nitrate, streptomycin sulfate and prednisolone valerate acetate
- TAMIYA Y.
- Hifu 31(supple 6), 206-211, 1989
- NAID 80004730971
Related Links
- sulconazole /sul·con·a·zole/ (sul-kon´ah-zōl) a broad-spectrum imidazole antifungal, used as the nitrate salt in the treatment of various forms of tinea and cutaneous candidiasis. sulconazole [sul-kon′ah-zōl] a broad-spectrum topical ...
- Sulconazole - Get up-to-date information on Sulconazole side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Sulconazole ... Sulconazole is a prescription medication used to treat fungal skin ...
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