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Micrograph showing squamous metaplasia (centre of image) in an atypical polypoid adenomyoma. H&E stain.

Squamous metaplasia refers to benign non-cancerous change (metaplasia) of (non-squamous) surfacing lining cells (epithelium) to a squamous morphology.

Location

Common sites for squamous metaplasia include the bladder and cervix. Smokers often exhibit squamous metaplasia in the linings of their airways. These changes don't signify a specific disease, but rather usually represent the body's response to stress or irritation. Vitamin A deficiency or overdose can also lead to squamous metaplasia.^[1]

Uterine cervix

In regard to the cervix, squamous metaplasia can sometimes be found in the endocervix, as it is composed of simple columnar epithelium, whereas the ectocervix is composed of stratified squamous non-keratinized epithelium .^[2]

Significance

Squamous metaplasia may be seen in the context of benign lesions (e.g. atypical polypoid adenomyoma), chronic irritation or cancer (e.g. endometrioid endometrial carcinoma).

References

^ Goralczyk, R (2009). "ß-Carotene and Lung Cancer in Smokers: Review of Hypotheses and Status of Research". Nutrition and Cancer 61 (6): 767–774. doi:10.1080/01635580903285155. PMID 20155614.
^ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; & Mitchell, Richard N. (2007) Robbins Basic Pathology (8th ed.). Saunders Elsevier. pp. 716-720 ISBN 978-1-4160-2973-1

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UpToDate Contents

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1. Cervical and vaginal cytology: Interpretation of results (Pap test report)
2. 子宮頚部細胞診：異型扁平上皮細胞（ASC-USおよびASC-H）の評価 cervical cytology evaluation of atypical squamous cells asc us and asc h
3. 頭頸部腫瘍の病理 pathology of head and neck neoplasms
4. 非尿路上皮膀胱癌 non urothelial bladder cancer
5. 肺悪性腫瘍の病理 pathology of lung malignancies

English Journal

Immunohistochemical study of metaplastic carcinoma and central acellular carcinoma of the breast: central acellular carcinoma is related to metaplastic carcinoma.

Yamaguchi R, Tanaka M, Kondo K, Yokoyama T, Maeda I, Tsuchiya S, Yamaguchi M, Takahashi R, Ogata Y, Abe H, Akiba J, Nakashima O, Kage M, Yano H.SourceDepartment of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan. rin@med.kurume-u.ac.jp
Medical molecular morphology.Med Mol Morphol.2012 Dec;45(1):14-21. Epub 2012 Mar 20.
Metaplastic breast cancers (MBCs) [spindle cell carcinoma (SpCC), squamous cell carcinoma (SCC), and matrix-producing carcinoma (MPC)] and invasive carcinomas with central acellular zones (CACs) were analyzed with respect to biological potential by immunohistochemical analyses. Specimens from 40 pat
PMID 22431179

Japanese Journal

後腹膜腔への巨大な転移腫瘤を伴った機能性悪性セルトリ細胞腫の犬の 1 例

日本獣医生命科学大学研究報告 (65), 34-38, 2016-12-01
NAID 120006246725

Poorly differentiated salivary gland carcinoma with prominent squamous metaplasia in a pregnant Wistar Hannover rat

Journal of Veterinary Medical Science 78(5), 859-862, 2016
NAID 130005154294

Poorly differentiated salivary gland carcinoma with prominent squamous metaplasia in a pregnant Wistar Hannover rat

Journal of Veterinary Medical Science advpub(0), 2016
NAID 130005119394

Related Pictures

病理標本：子宮頸部，扁平上皮化生|新潟大学医学部臨床病理学 Squamous metaplasia - Wikipedia File:Squamous metaplasia in endocervical gland.jpg - Wikimedia Commons Lecture 1 Cellular Responses at Midwestern University (AZ) - StudyBlue Squamous Metaplasia of Uterine Cervix File:Immature squamous metaplasia - anus -- intermed mag.jpg - Wikimedia Commons File:Keratinizing squamous metaplasia of the urinary bladder, intermed. mag.jpg