sphingosine N-acyltransferase

スフィンゴシンN-アシルトランスフェラーゼ

WordNet

1. the 14th letter of the Roman alphabet (同)n

PrepTutorEJDIC

1. nitrogenの化学記号
2. neodymiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/13 22:01:25」(JST)

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sphingosine N-acyltransferase
Identifiers
EC number	2.3.1.24
CAS number	37257-09-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a sphingosine N-acyltransferase (EC 2.3.1.24) is an enzyme that catalyzes the chemical reaction

acyl-CoA + sphingosine CoA + N-acylsphingosine

Thus, the two substrates of this enzyme are acyl-CoA and sphingosine, whereas its two products are CoA and N-acylsphingosine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:sphingosine N-acyltransferase. Other names in common use include ceramide synthetase, and sphingosine acyltransferase. This enzyme participates in sphingolipid metabolism.

References

• Sribney M (1966). "Enzymatic synthesis of ceramide". Biochim. Biophys. Acta. 125 (3): 542–7. PMID 5973195. 

UpToDate Contents

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English Journal

• Children with severe asthma have unique oxidative stress-associated metabolomic profiles.

• Fitzpatrick AM1, Park Y2, Brown LA3, Jones DP4.
• The Journal of allergy and clinical immunology.J Allergy Clin Immunol.2014 Jan;133(1):258-61.e1-8. doi: 10.1016/j.jaci.2013.10.012.
• PMID 24369802

• Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization.

• Park WJ1, Park JW, Erez-Roman R, Kogot-Levin A, Bame JR, Tirosh B, Saada A, Merrill AH Jr, Pewzner-Jung Y, Futerman AH.
• The Journal of biological chemistry.J Biol Chem.2013 Oct 25;288(43):30904-16. doi: 10.1074/jbc.M112.448852. Epub 2013 Sep 9.
• Very long chain (C22-C24) ceramides are synthesized by ceramide synthase 2 (CerS2). A CerS2 null mouse displays hepatopathy because of depletion of C22-C24 ceramides, elevation of C16-ceramide, and/or elevation of sphinganine. Unexpectedly, CerS2 null mice were resistant to acetaminophen-induced hep
• PMID 24019516

• Impaired epidermal ceramide synthesis causes autosomal recessive congenital ichthyosis and reveals the importance of ceramide acyl chain length.

• Eckl KM1, Tidhar R, Thiele H, Oji V, Hausser I, Brodesser S, Preil ML, Onal-Akan A, Stock F, Müller D, Becker K, Casper R, Nürnberg G, Altmüller J, Nürnberg P, Traupe H, Futerman AH, Hennies HC.
• The Journal of investigative dermatology.J Invest Dermatol.2013 Sep;133(9):2202-11. doi: 10.1038/jid.2013.153. Epub 2013 Apr 2.
• The barrier function of the human epidermis is supposed to be governed by lipid composition and organization in the stratum corneum. Disorders of keratinization, namely ichthyoses, are typically associated with disturbed barrier activity. Using autozygosity mapping and exome sequencing, we have iden
• PMID 23549421

Japanese Journal

• Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in ucltured neurons in situ

• J Biol Chem 268, 27299-27306, 1993
• NAID 80007397992

Related Links

• Sphingosine N-Acyltransferase

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• Sphingosine N-Acyltransferase - RightDiagnosis.com

Sphingosine N-Acyltransferase information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Sphingosine N-Acyltransferase Description of Sphingosine N ...

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★リンクテーブル★

リンク元	「スフィンゴシンN-アシルトランスフェラーゼ」
関連記事	「acyltransferase」「n」「N」「Nd」

「スフィンゴシンN-アシルトランスフェラーゼ」

　　[★]

英

sphingosine N-acyltransferase

「acyltransferase」

　　[★]

アシルトランスフェラーゼ、アシル転移酵素、アシル基転移酵素

関

transacylase

「n」

　　[★]

• n.

• 例数

関

number of experiment、sample size

• pの前の[n]はmと記載する。synptom→symptom

「N」

　　[★]

• アスパラギン asparagine
• 窒素(原子、分子)

　 　

「Nd」

　　[★] ネオジム neodymium