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Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis.

Welsh P, Sass-Kuhn S, Prakashagowda C, McCloskey D, Feith D.SourcePenn State University College of Medicine, 500 University Dr., Hershey, PA 17033, United States.
Cancer biology & therapy.Cancer Biol Ther.2012 Apr 15;13(8). [Epub ahead of print]
Numerous studies have demonstrated a link between elevated polyamine biosynthesis and neoplastic growth, but the specific contribution of spermine synthase to epithelial tumor development has never been explored in vivo. Mice with widespread overexpression of spermine synthase (CAG-SpmS) exhibit dec
PMID 22258329

Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis.

Chaturvedi R, de Sablet T, Coburn LA, Gobert AP, Wilson KT.SourceDivision of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, 1030C MRBIV, 2215 Garland Avenue, Nashville, TN, 37232, USA.
Amino acids.Amino Acids.2012 Feb;42(2-3):627-40. Epub 2011 Aug 28.
L: -arginine (L: -Arg) is metabolized by nitric oxide synthase and arginase enzymes. The gastric pathogen Helicobacter pylori causes peptic ulcer disease and gastric cancer. We have shown that alterations in L: -Arg availability and metabolism into polyamines contribute significantly to the dysregul
PMID 21874531

Thermospermine suppresses auxin-inducible xylem differentiation in Arabidopsis thaliana

Yoshimoto Kaori,Noutoshi Yoshiteru,Hayashi Ken-ichiro,Shirasu Ken,Takahashi Taku,Motose Hiroyasu
Plant Signaling & Behavior 7(8), 937-939, 2012-08
… Thermospermine, a structural isomer of spermine, is synthesized by a thermospermine synthase designated ACAULIS5 (ACL5). …
NAID 120004920209

Determination of Cellular Aminopropyltransferase Activity Using Precolumn Fluorescent Etheno-Derivatization with High-Performance Liquid Chromatography

山嵜健一,池口文彦,丹波卓也,林香瑠,岩城孝宏,石井育美,新津勝,Pegg Anthony E.,白幡晶
Analytical Sciences 28(6), 621-624, 2012-06
… Polyamines such as spermidine (Spd) and spermine (Spm), produced by aminopropyltransferase (Apt), play roles in cell growth and differentiation. … A sensitive and simple fluorometric high-performance liquid chromatographic determination for Apt activity of spermidine synthase (Spdsyn) and spermine synthase (Spmsyn) was developed in order to examine cellular functions of polyamine synthesis. …
NAID 120005520708

石井育美,池口文彦,真野博,和田政裕,Pegg Anthony E.,白幡晶
Amino Acids 42(2-3), 619-626, 2012-02
… Polyamines spermidine and spermine are known to be required for mammalian cell proliferation and for embryonic development. … The spermidine synthase inhibitor trans-4-methylcyclohexylamine (MCHA) increased spermine/spermidine ratios, whereas the spermine synthase inhibitor N-(3-aminopropyl)-cyclohexylamine (APCHA) decreased the ratios in the cells. …
NAID 120005520696