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Spermine synthase |
Identifiers |
EC number |
2.5.1.22 |
CAS number |
74812-43-4 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
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Spermine synthase (EC 2.5.1.22, spermidine aminopropyltransferase, spermine synthetase) is an enzyme that converts spermidine into spermine.[1][2] This enzyme catalyses the following chemical reaction
- S-adenosylmethioninamine + spermidine S-methyl-5'-thioadenosine + spermine
References
- ^ Hibasami, H., Borchardt, R.T., Chen, S.-Y., Coward, J.K. and Pegg, A.E. (1980). "Studies of inhibition of rat spermidine synthase and spermine synthase". Biochem. J. 187 (2): 419–428. PMC 1161808. PMID 7396856.
- ^ Pajula, R.-L., Raina, A. and Eloranta, T. (1979). "Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain". Eur. J. Biochem. 101 (2): 619–626. doi:10.1111/j.1432-1033.1979.tb19756.x. PMID 520313.
External links
- Spermine synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 2.5.1.22
- SMS
Transferases: alkyl and aryl (EC 2.5)
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2.5.1 |
- Dimethylallyltranstransferase
- Thiaminase I
- Methionine adenosyltransferase
- Riboflavin synthase
- Dihydropteroate synthase
- Spermidine synthase
- Glutathione S-transferase
- Farnesyl-diphosphate farnesyltransferase
- Spermine synthase
- Alkylglycerone phosphate synthase
- Farnesyltransferase
- Geranylgeranyltransferase type 1
- Porphobilinogen deaminase
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- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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English Journal
- Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis.
- Welsh P, Sass-Kuhn S, Prakashagowda C, McCloskey D, Feith D.SourcePenn State University College of Medicine, 500 University Dr., Hershey, PA 17033, United States.
- Cancer biology & therapy.Cancer Biol Ther.2012 Apr 15;13(8). [Epub ahead of print]
- Numerous studies have demonstrated a link between elevated polyamine biosynthesis and neoplastic growth, but the specific contribution of spermine synthase to epithelial tumor development has never been explored in vivo. Mice with widespread overexpression of spermine synthase (CAG-SpmS) exhibit dec
- PMID 22258329
- Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis.
- Chaturvedi R, de Sablet T, Coburn LA, Gobert AP, Wilson KT.SourceDivision of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, 1030C MRBIV, 2215 Garland Avenue, Nashville, TN, 37232, USA.
- Amino acids.Amino Acids.2012 Feb;42(2-3):627-40. Epub 2011 Aug 28.
- L: -arginine (L: -Arg) is metabolized by nitric oxide synthase and arginase enzymes. The gastric pathogen Helicobacter pylori causes peptic ulcer disease and gastric cancer. We have shown that alterations in L: -Arg availability and metabolism into polyamines contribute significantly to the dysregul
- PMID 21874531
Japanese Journal
- Thermospermine suppresses auxin-inducible xylem differentiation in Arabidopsis thaliana
- Yoshimoto Kaori,Noutoshi Yoshiteru,Hayashi Ken-ichiro,Shirasu Ken,Takahashi Taku,Motose Hiroyasu
- Plant Signaling & Behavior 7(8), 937-939, 2012-08
- … Thermospermine, a structural isomer of spermine, is synthesized by a thermospermine synthase designated ACAULIS5 (ACL5). …
- NAID 120004920209
- Determination of Cellular Aminopropyltransferase Activity Using Precolumn Fluorescent Etheno-Derivatization with High-Performance Liquid Chromatography
- 山嵜 健一,池口 文彦,丹波 卓也,林 香瑠,岩城 孝宏,石井 育美,新津 勝,Pegg Anthony E.,白幡 晶
- Analytical Sciences 28(6), 621-624, 2012-06
- … Polyamines such as spermidine (Spd) and spermine (Spm), produced by aminopropyltransferase (Apt), play roles in cell growth and differentiation. … A sensitive and simple fluorometric high-performance liquid chromatographic determination for Apt activity of spermidine synthase (Spdsyn) and spermine synthase (Spmsyn) was developed in order to examine cellular functions of polyamine synthesis. …
- NAID 120005520708
- Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells
- 石井 育美,池口 文彦,真野 博,和田 政裕,Pegg Anthony E.,白幡 晶
- Amino Acids 42(2-3), 619-626, 2012-02
- … Polyamines spermidine and spermine are known to be required for mammalian cell proliferation and for embryonic development. … The spermidine synthase inhibitor trans-4-methylcyclohexylamine (MCHA) increased spermine/spermidine ratios, whereas the spermine synthase inhibitor N-(3-aminopropyl)-cyclohexylamine (APCHA) decreased the ratios in the cells. …
- NAID 120005520696
Related Links
- It is also likely that plants do not require spermine for normal growth since mutants where the SPMS gene that encodes spermine synthase is inactivated are viable but contain no spermine [22]. The absence of spermine may lead to ...
- Spermine synthase on ResearchGate, the professional network for scientists. ... [Show abstract] [Hide abstract] ABSTRACT: Polyamines are essential metabolites present in all living organisms, and this subject has attracted the ...
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★リンクテーブル★
[★]
- 英
- spermine synthase
- 関
- スペルミンシンターゼ
[★]
- 英
- spermine synthase
- 関
- スペルミン合成酵素
[★]
- 関
- lyase、synthetase、transferase