関: SOS

WordNet

an internationally recognized distress signal in radio code
to a very great extent or degree; "the idea is so obvious"; "never been so happy"; "I love you so"; "my head aches so!"
(usually followed by `that'
in a manner that facilitates; "he observed the snakes so he could describe their behavior"; "he stooped down so he could pick up his hat"
in such a condition or manner, especially as expressed or implied; "Theyre happy and I hope they will remain so"; "so live your life that old age will bring no regrets"
in the same way; also; "I was offended and so was he"; "worked hard and so did she"
to a certain unspecified extent or degree; "I can only go so far with this student"; "can do only so much in a day"
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
a male human offspring; "their son became a famous judge"; "his boy is taller than he is" (同)boy
the divine word of God; the second person in the Trinity (incarnate in Jesus) (同)Word, Logos

PrepTutorEJDIC

(船・飛行機などの)遭難無電信号 / 救助を求める声
《様態の指示》『そういうふうに』,『そのように』・《補語に用いて》『そのようで』,そうで・《程度》『それほど』,そんなに・《強意として》《話》『非常に』,『とても』,たいへん・《前に述べたことの内容に対する同意を表して;「so+主語+[助]動詞」》『その通りで』,『本当に』,確かに,おっしゃるとおり・《肯定文を受けて;「so+[助]動詞+主語」の語順で》…『もまた』,『も同様に』・《as~, so…で》~と同じように…,(~のように)そのように・《目的を表して》…『するように』・《理由・結果を表して》『その結果』,それで・《文・節の頭に用いて》『それで』,だから・《驚き・賛成・嫌悪・疑いなどを表して》そうか,そうなんだ,どうかな,まさか・それでよし
=sol
《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
蛋白(たんばく)質
『息子』・《複数形で》(男子の)子孫・《文》《比喩(ひゆ)的に》(場所・主義などの)子,後継者・《年長者が年少者に呼び掛けて》・お前さん・《the S-》イエスキリスト

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1. プロテインS欠乏症：臨床症状および診断 protein s deficiency clinical manifestations and diagnosis
2. プロテインC欠乏症：臨床症状および診断 protein c deficiency clinical manifestations and diagnosis
3. Food protein-induced proctocolitis and enteropathy of infancy
4. 第V因子ライデンおよび活性化プロテインC抵抗性：臨床症状および診断 factor v leiden and activated protein c resistance clinical manifestations and diagnosis
5. インスリン様成長因子 Iの生理学 physiology of insulin like growth factor i

English Journal

Activating mutations affecting the Dbl homology domain of SOS2 cause Noonan syndrome.

Cordeddu V1,2, Yin JC3, Gunnarsson C4, Virtanen C3, Drunat S5, Lepri F6, De Luca A7, Rossi C8, Ciolfi A1, Pugh TJ3, Bruselles A1, Priest JR9,10, Pennacchio LA11,12, Lu Z3, Danesh A3, Quevedo R3, Hamid A3, Martinelli S1, Pantaleoni F1, Gnazzo M6, Daniele P7, Lissewski C13, Bocchinfuso G14, Stella L14, Odent S15, Philip N16, Faivre L17, Vlckova M18, Seemanova E18, Digilio C6, Zenker M13, Zampino G19, Verloes A5, Dallapiccola B6, Roberts AE20, Cavé H5,21, Gelb BD22, Neel BG3,23, Tartaglia M1,6.
Human mutation.Hum Mutat.2015 Jul 14. doi: 10.1002/humu.22834. [Epub ahead of print]
The RASopathies constitute a family of autosomal dominant disorders whose major features include facial dysmorphism, cardiac defects, reduced postnatal growth, variable cognitive deficits, ectodermal and skeletal anomalies, and susceptibility to certain malignancies. Noonan syndrome (NS), the common
PMID 26173643

MEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma.

Kong LR1, Chua KN1, Sim WJ2, Ng HC2, Bi C1, Ho J3, Nga ME4, Pang YH4, Ong WR5, Soo RA6, Huynh H5, Chng WJ6, Thiery JP7, Goh BC8.
Molecular cancer therapeutics.Mol Cancer Ther.2015 Jul;14(7):1750-60. doi: 10.1158/1535-7163.MCT-15-0062. Epub 2015 May 4.
Genomic analyses of squamous cell carcinoma (SCC) have yet to yield significant strategies against pathway activation to improve treatment. Platinum-based chemotherapy remains the mainstay of treatment for SCC of different histotypes either as a single-agent or alongside other chemotherapeutic drugs
PMID 25939760

miR-146a and miR-370 coordinate enterovirus 71-induced cell apoptosis through targeting SOS1 and GADD45β.

Chang YL1, Ho BC2,3, Sher S4, Yu SL2,3,5,6,7, Yang PC1,3,8,9.
Cellular microbiology.Cell Microbiol.2015 Jun;17(6):802-18. doi: 10.1111/cmi.12401. Epub 2015 Jan 24.
Enterovirus 71 (EV71) is an emerging life-threatening pathogen particularly in the Asia-Pacific region. The major pathogenic feature in EV71-infected cells is apoptosis. However, which molecular mechanism mainly contributes to EV71-induced apoptosis is not investigated thoroughly. MicroRNAs (MiRNAs)
PMID 25469565

Japanese Journal

Activated O2•− and H2O2 Mediated Cell Survival in SU11274-Treated Non-Small-Cell Lung Cancer A549 Cells via c-Met–PI3K–Akt and c-Met–Grb2/SOS–Ras–p38 Pathways

Liu Ying,Shi Qi-Feng,Ye Yuan-Chao,Tashiro Shin-ichi,Onodera Satoshi,Ikejima Takashi
Journal of
… The pharmacological activity of SU11274 is primarily due to its inhibition of hepotocyte growth factor receptor (c-Met) kinase overexpression. … In this study, we demonstrated that the pathway involved in SU11274-induced autophagy was presumably through inhibition of c-Met and its down-stream pathways, including phosphatidylinositol 3-kinases – …
NAID 130001889277

Interaction between Pleckstrin Homology Domains and G Protein βγ-Subunits : Analyses of Kinetic Parameters by a Biosensor-Based Method

SAWAI Tohru,HIRAKAWA Tetsuya,YAMADA Koji,NISHIZAWA Yukio
Biological & pharmaceutical bulletin 22(3), 229-233, 1999-03-15
… Pleckstrin homology (PH) domains, comprised of rather weakly conserved sequences of about 100 amino acid residues, are a protein motif found in many signaling and cytoskeletal proteins. … PH domains have been shown to bind to the βγ subunits of heterotrimeric GTP-binding proteins (G_<βγ>), but the affinity of PH domains for G_<βγ> …
NAID 110003639644