WordNet

any compound that contains water of crystallization
become hydrated and combine with water
cause to be hydrated; add water or moisture to; "hydrate your skin"
supply water or liquid to in order to maintain a healthy balance; "the bicyclists must be hydrated frequently"
a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
small tubular solitary freshwater hydrozoan polyp
trouble that cannot be overcome by a single effort because of its many aspects or its persistent and pervasive quality; "we may be facing a hydra that defies any easy solution"

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Sivelestat sodium hydrate reduces radiation-induced lung injury in mice by inhibiting neutrophil elastase.

Yoshikawa N, Inomata T, Okada Y, Shimbo T, Takahashi M, Akita K, Uesugi Y, Narumi Y.SourceDepartment of Radiology, Osaka Medical College, Takatsuki, Osaka 569-8686, Japan. rad101@poh.osaka-med.ac.jp
Molecular medicine reports.Mol Med Rep.2013 Apr;7(4):1091-5. doi: 10.3892/mmr.2013.1318. Epub 2013 Feb 8.
The aim of this study was to investigate whether sivelestat, a neutrophil elastase (NE) inhibitor, mitigates radiation-induced lung injury in mice. C57BL/6J mice were administered a dose of 20 Gy to the bilateral whole lungs. Sivelestat was administered immediately before and 1 h after irradiation i
PMID 23404144

Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats.

Fujimura N, Obara H, Suda K, Takeuchi H, Miyasho T, Kawasako K, Du W, Yamada S, Ono S, Matsumoto K, Matsuda S, Yagi H, Kitago M, Shinoda M, Itano O, Tanabe M, Sakamoto M, Maruyama I, Kitagawa Y.SourceDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
The Journal of surgical research.J Surg Res.2013 Mar;180(1):e31-6. doi: 10.1016/j.jss.2012.04.037. Epub 2012 May 8.
BACKGROUND: Sivelestat sodium hydrate is a specific neutrophil elastase inhibitor effective in acute lung injury (ALI) associated with systemic inflammatory response syndrome. Bowel ischemia reperfusion injury (IRI) induced by supravisceral aortic clamping is associated with an excessive systemic in
PMID 22595015

Emphysematous cystitis following a transrectal needle guided biopsy of the prostate.

Hashimoto T, Namiki K, Tanaka A, Shimodaira K, Gondo T, Tachibana M.SourceDepartment of Urology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
BMC infectious diseases.BMC Infect Dis.2012 Nov 26;12:322. doi: 10.1186/1471-2334-12-322.
BACKGROUND: Emphysematous cystitis (EC) is a comparatively rare urinary tract infection characterized by air within the bladder wall and lumen and is usually associated with immunosuppression or poorly controlled diabetes mellitus.CASE PRESENTATION: We report a case of EC in a 70-year-old man who re
PMID 23176639

The Effect of Sivelestat Sodium Hydrate on Severe Respiratory Failure after Thoracic Aortic Surgery with Deep Hypothermia

Morimoto Keisuke,Nishimura Kengo,Miyasaka Shigeto,Maeta Hiroyuki,Taniguchi Iwao
Annals of Thoracic and Cardiovascular Surgery 17(4), 369-375, 2011
… A specific neutrophil elastase inhibitor, sivelestat sodium hydrate, is an innovative therapeutic drug for acute lung injury. … We evaluated the protective effects of sivelestat sodium hydrate on severe lung injury after thoracic aortic surgery with deep hypothermia. …
NAID 130000728025

In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.

Morinaga Yoshitomo,Yanagihara Katsunori,Araki Nobuko,Yamada Koichi,Seki Masafumi,Izumikawa Koichi,Kakeya Hiroshi,Yamamoto Yoshihiro,Yamada Yasuaki,Kohno Shigeru,Kamihira Shimeru
Experimental lung research 36(8), 484-490, 2010-10
… Sivelestat sodium hydrate (sivelestat), a neutrophil elastase inhibitor, is used in the treatment of lung injury but its effect on bacterial pneumonia is unknown. … The authors examined the efficacy of sivelestat in combination with a fluoroquinolone in a Legionella pneumophila pneumonia mouse model. …
NAID 120003367667

注射用エラスポール100

注射用エラスポール100

好中球エラスターゼは蛋白分解酵素の一つであり、肺に集積した好中球から遊離される。好中球エラスターゼは肺結合組織を分解し、肺血管透過性を亢進させ、急性肺障害を誘発させる。また、好中球遊走因子の産生を促進し、炎症反応を増幅させ、全身性炎症反応症候群に伴う急性肺障害における重要な障害因子として注目されている。本剤は、好中球エラスターゼの選択的な阻害剤である。