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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/31 09:00:53」(JST)

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Sivelestat relaxes vascular smooth muscle contraction in human gastric arteries.

Amemori H, Maeda Y, Torikai A, Nakashima M.SourceDepartment of Anesthesiology and Critical Care Medicine, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan, amemohi@cc.saga-u.ac.jp.
Journal of physiology and biochemistry.J Physiol Biochem.2011 Dec;67(4):589-93. Epub 2011 Jul 14.
Sivelestat sodium hydrate (sivelestat) is a novel synthetic drug and specific inhibitor of neutrophil elastase that has been approved in Japan as a treatment for acute lung injury associated with systemic inflammatory response syndrome. It is important to determine how sivelestat affects hemodynamic
PMID 21755354

AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase.

Stevens T, Ekholm K, Gränse M, Lindahl M, Kozma V, Jungar C, Ottosson T, Falk-Håkansson H, Churg A, Wright JL, Lal H, Sanfridson A.SourceAstraZeneca AB, Lund, Sweden.
The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2011 Oct;339(1):313-20. Epub 2011 Jul 26.
N-{[5-(methanesulfonyl)pyridin-2-yl]methyl}-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide (AZD9668) is a novel, oral inhibitor of neutrophil elastase (NE), an enzyme implicated in the signs, symptoms, and disease progression in NE-driven
PMID 21791628

松崎恭介,奥見雅由,岸本望 [他],矢澤浩治,宮川康,内田欽也,野々村祝夫
泌尿器科紀要 = Acta urologica Japonica 59(7), 443-447, 2013-07
… Neoadjuvant systemic chemotherapy was performed along with use of steroid and sivelestat, which ameliorated the respiratory distress. …
NAID 120005308132

A case of left pneumothorax followed by adult respiratory distress syndrome (ARDS)

宮原栄治,板垣友子,桑原正樹,亀田彰
日本呼吸器外科学会雑誌 27(1), 44-49, 2013
… He was diagnosed with ARDS, and started treatment with corticosteroids and sivelestat sodium hydrate. …
NAID 130003368739

Neutrophil Elastase Inhibitor Sivelestat Attenuates Perioperative Inflammatory Response in Pediatric Heart Surgery With Cardiopulmonary Bypass:A Prospective Randomized Study

Inoue Nobuyuki,Oka Norihiko,Kitamura Tadashi,Shibata Ko,Itatani Keiichi,Tomoyasu Takahiro,Miyaji Kagami
International Heart Journal 54(3), 149-153, 2013
… Sivelestat has been used clinically to treat acute lung injury associated with systemic inflammatory response syndrome. … This prospective, doubleblind, randomized study was designed to evaluate the effects of sivelestat in the perioperative period of elective pediatric open-heart surgery with CPB. … Twenty-six consecutive pediatric patients weighing between 5 and 10 kg and undergoing open-heart surgery with CPB were divided into a sivelestat group (<I>n</I> …
NAID 130003364460

リンク元	「シベレスタット」
拡張検索	「sivelestat sodium hydrate」

Sivelestat
Systematic (IUPAC) name
	N-{2-[({4-[(2,2-dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only;
Routes	IV
Identifiers
CAS number	127373-66-4
ATC code	None
PubChem	CID 107706
ChemSpider	96875
UNII	DWI62G0P59
KEGG	D03788
ChEMBL	CHEMBL76688
Chemical data
Formula	C20H22N2O7S
Mol. mass	434.46 g/mol
	SMILES CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O;
	InChI InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24) ; Key:BTGNGJJLZOIYID-UHFFFAOYSA-N ;
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注射用エラスポール100

注射用エラスポール100

好中球エラスターゼは蛋白分解酵素の一つであり、肺に集積した好中球から遊離される。好中球エラスターゼは肺結合組織を分解し、肺血管透過性を亢進させ、急性肺障害を誘発させる。また、好中球遊走因子の産生を促進し、炎症反応を増幅させ、全身性炎症反応症候群に伴う急性肺障害における重要な障害因子として注目されている。本剤は、好中球エラスターゼの選択的な阻害剤である。