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Fukatsu K.Author information Surgical Center, The University of Tokyo, Tokyo, Japan.AbstractPURPOSE OF REVIEW: Enteral nutrition is recommended as a standard nutritional therapy in clinical settings. The rationale behind enteral nutrition may be decreased infectious morbidities compared with parenteral nutrition. However, the mechanism may not be well understood.
Current opinion in clinical nutrition and metabolic care.Curr Opin Clin Nutr Metab Care.2014 Mar;17(2):164-70. doi: 10.1097/MCO.0000000000000033.
PURPOSE OF REVIEW: Enteral nutrition is recommended as a standard nutritional therapy in clinical settings. The rationale behind enteral nutrition may be decreased infectious morbidities compared with parenteral nutrition. However, the mechanism may not be well understood.RECENT FINDINGS: Animal stu
PMID 24500441

Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2.

Xue M, Shen K, McKelvey K, Li J, Chan YK, Hatzis V, March L, Little CB, Tonkin M, Jackson CJ.AbstractINTRODUCTION: Rheumatoid synovial fibroblasts (RASF) mediate joint inflammation and destruction in rheumatoid arthritis (RA). Endothelial protein C receptor (EPCR) is a specific receptor for the natural anticoagulant activated protein C (APC). It mediates the cytoprotective properties of APC and is expressed in rheumatoid synovial tissue. A recent report shows that group V secretory phospholipase A2 (sPLA2V) prevents APC from binding to EPCR in endothelium and inhibits EPCR/APC function. The aim of this study was to investigate the expression and function of EPCR on RASF.
Arthritis research & therapy.Arthritis Res Ther.2014 Feb 5;16(1):R44. [Epub ahead of print]
INTRODUCTION: Rheumatoid synovial fibroblasts (RASF) mediate joint inflammation and destruction in rheumatoid arthritis (RA). Endothelial protein C receptor (EPCR) is a specific receptor for the natural anticoagulant activated protein C (APC). It mediates the cytoprotective properties of APC and is
PMID 24495480

IL-25 Improves Luminal Innate Immunity and Barrier Function During Parenteral Nutrition.

Heneghan AF, Pierre JF, Gosain A, Kudsk KA.Author information *Department of Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI; and †Veteran Administration Surgical Service, William S. Middleton Memorial Veterans Hospital, Madison, WI.AbstractBACKGROUND: Parenteral nutrition (PN) increases risks of infections in critically injured patients. Recently, PN was shown to reduce intestine luminal levels of the Paneth cell antimicrobial molecule secretory phospholipase A2 (sPLA2) and the goblet cell glycoprotein mucin2 (MUC2). These molecules are critical factors for innate mucosal immunity and provide barrier protection. Interleukin-4 (IL-4) and IL-13 regulate sPLA2 and MUC2 production through the IL-13 receptor. Because IL-25 stimulates IL-4 and IL-13 release and PN reduces luminal sPLA2 and MUC2, we hypothesized that adding IL-25 to PN would restore these innate immune factors and maintain barrier function.
Annals of surgery.Ann Surg.2014 Feb;259(2):394-400. doi: 10.1097/SLA.0b013e318284f510.
BACKGROUND: Parenteral nutrition (PN) increases risks of infections in critically injured patients. Recently, PN was shown to reduce intestine luminal levels of the Paneth cell antimicrobial molecule secretory phospholipase A2 (sPLA2) and the goblet cell glycoprotein mucin2 (MUC2). These molecules a
PMID 23426341

Peculiar Composition of Epithelial Cells in Follicle-Associated Intestinal Crypts of Peyer's Patches in the Rat Small Intestine

MANTANI Youhei,YUASA Hideto,NISHIDA Miho,TAKAHARA Ei-ichirou,OMOTEHARA Takuya,UDAYANGA Kankanam Gamage Sanath,KAWANO Junichi,YOKOYAMA Toshifumi,HOSHI Nobuhiko,KITAGAWA Hiroshi
Journal of Veterinary Medical Science, 2014
… The characteristics of secretory granules in Paneth cells and goblet cells of both the FAIC and ordinary intestinal crypts (IC) were almost same in periodic acid-Schiff (PAS) reaction, Alcian blue (AB) staining and the immunohistochemical detection of lysozymes and soluble phospholipase A2. …
NAID 130003391293

Role of Secretory Phospholipase A₂ in Rhythmic Contraction of Pulmonary Arteries of Rats With Monocrotaline-Induced Pulmonary Arterial Hypertension

Tanabe Yoshiyuki,Saito-Tanji Maki,Morikawa Yuki [他],KAMATAKI Akihisa,SAWAI Takashi,NAKAYAMA Koichi
Journal of pharmacological sciences 119(3), 271-281, 2012-07-20
… We previously reported that indoxam, a selective inhibitor for secretory phospholipase A<SUB>2</SUB> …
NAID 10030987037

Inhibition of Untransformed Prostaglandin H_2 Production and Stretch-Induced Contraction of Rabbit Pulmonary Arteries by Indoxam, a Selective Secretory Phospholipase A_2 Inhibitor

Tanabe Yoshiyuki,Saito Maki,Morikawa Yuki [他],KAMATAKI Akihisa,SAWAI Takashi,HIROSE Masamichi,NAKAYAMA Koichi
Journal of pharmacological sciences 115(4), 525-531, 2011-04-20
… Involvement of secretory phospholipase A<SUB>2</SUB> …
NAID 10029893573