WordNet

the organic process of synthesizing and releasing some substance (同)secernment
a functionally specialized substance (especially one that is not a waste) released from a gland or cell
any of various organs that synthesize substances needed by the body and release it through ducts or directly into the bloodstream (同)secretory organ, secretor, secreter

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〈C〉分泌(ぶんぴつ)作用(過程) / 〈C〉分泌物 / 〈U〉(…を)隠すこと《+『of』+『名』》
(生物体内の)腺(せん)

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1. 副甲状腺ホルモンの分泌および作用 parathyroid hormone secretion and action
2. 唾液腺腫瘍：疫学、診断、評価、および病期分類 salivary gland tumors epidemiology diagnosis evaluation and staging
3. 唾石症 salivary gland stones
4. シェーグレン症候群の診断および分類 diagnosis and classification of sjogrens syndrome
5. 甲状腺ホルモンとの薬物相互作用 drug interactions with thyroid hormones

English Journal

A novel MDCKII in vitro model for assessing ABCG2-drug interactions and regulation of ABCG2 transport activity in the caprine mammary gland by environmental pollutants and pesticides.

Halwachs S1, Wassermann L2, Honscha W3.Author information 1Institute of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Universität Leipzig, An den Tierkliniken 15, 04103 Leipzig, Germany. Electronic address: halwachs@vetmed.uni-leipzig.de.2Institute of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Universität Leipzig, An den Tierkliniken 15, 04103 Leipzig, Germany. Electronic address: wassermann@vetmed.uni-leipzig.de.3Institute of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Universität Leipzig, An den Tierkliniken 15, 04103 Leipzig, Germany. Electronic address: honscha@vetmed.uni-leipzig.de.AbstractThe ABC efflux transporter ABCG2 represents the main route for active secretion of xenobiotics into milk. Thus, ABCG2 regulation by aryl hydrocarbon receptor (AhR) ligands including ubiquitously environmental pollutants is of great toxicological relevance. However, no adequate in vitro model is as yet available to study AhR-dependent ABCG2 regulation in dairy animals. In this study, we therefore systematically investigated the effect of various environmental contaminants and pesticides on ABCG2 efflux activity in MDCKII cells stably expressing mammary ABCG2 from dairy goats. The AhR-agonists TCDD, Aroclor 1254, prochloraz, and iprodione caused a dose- and time-dependent increase in EROD activity. Moreover, TCDD and prochloraz significantly stimulated ABCG2 transport activity through a dose- and time-dependent induction of transporter gene expression. AhR inhibitors like CH223191 significantly reversed TCDD- and prochloraz-induced stimulation of ABCG2 efflux activity. In contrast, non-AhR activators such as PCB 101 had no significant effect on EROD activity, ABCG2 gene expression or transporter activity. As we identified various anthelmintics including monepantel as potential ABCG2 substrates this regulatory mechanism may result in increased milk residues of potentially harmful xenobiotics. Thus, MDCKII-cABCG2 cells may represent a suitable in vitro model to study mammary ABCG2 secretory activity and its potential regulation by AhR-activating contaminants.
Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2014 Apr;28(3):432-41. doi: 10.1016/j.tiv.2013.12.015. Epub 2014 Jan 3.
The ABC efflux transporter ABCG2 represents the main route for active secretion of xenobiotics into milk. Thus, ABCG2 regulation by aryl hydrocarbon receptor (AhR) ligands including ubiquitously environmental pollutants is of great toxicological relevance. However, no adequate in vitro model is as y
PMID 24389113

A3.3 Inflammasome is activated in healthy salivary gland epithelial cell lines by necrotic cell debris, whereas it is constitutively active in the epithelial cells of Sjogren's syndrome patients.

Vakrakou AG, Manoussakis MN.Author information Department Pathophysiology, University of Athens, Greece.AbstractBACKGROUND AND OBJECTIVES: In our laboratory, recent transcriptome expression analysis of unstimulated cultured non-neoplastic salivary gland epithelial cell lines (SGEC) from Sjögren's syndrome (SS) patients and non-SS controls had indicated the aberrant expression of various inflammatory genes in the SS-SGEC supporting their intrinsic activation status. Additionally, we have recently presented evidence of impaired removal of apoptotic cells and necrotic cell debris (SNEC) in SS patients. Here, we sought to investigate the effect of SNEC in cultured SGEC, as well as the expression of various inflammasome-related genes and proteins in salivary gland tissues and SGEC from SS patients and non-SS controls.
Annals of the rheumatic diseases.Ann Rheum Dis.2014 Mar 1;73 Suppl 1:A42-3. doi: 10.1136/annrheumdis-2013-205124.97.
BACKGROUND AND OBJECTIVES: In our laboratory, recent transcriptome expression analysis of unstimulated cultured non-neoplastic salivary gland epithelial cell lines (SGEC) from Sjögren's syndrome (SS) patients and non-SS controls had indicated the aberrant expression of various inflammatory genes in
PMID 24489219

P2X7 receptors in neurohypophysial terminals: evidence for their role in arginine-vasopressin secretion.

Cuadra AE, Custer EE, Bosworth EL, Lemos JR.Author information Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts.AbstractArginine-vasopressin (AVP) plays a major role in maintaining cardiovascular function and related pathologies. The mechanism involved in its release into the circulation is complex and highly regulated. Recent work has implicated the purinergic receptor, P2X7R, in a role for catecholamine-enhanced AVP release in the rat hypothalamic-neurohypophysial (NH) system. However, the site of P2X7R action in this endocrine system, and whether or not it directly mediates release in secretory neurons have not been determined. We hypothesized that the P2X7R is expressed and mediates AVP release in NH terminals. P2X7R function was first examined by patch-clamp recordings in isolated NH terminals. Results revealed that subpopulations of isolated terminals displayed either high ATP-sensitivity or low ATP-sensitivity, the latter of which was characteristic of the rat P2X7R. Additional recordings showed that terminals showing sensitivity to the P2X7R-selective agonist, BzATP, were further inhibited by P2X7R selective antagonists, AZ10606120 and brilliant blue-G. In confocal micrographs from tissue sections and isolated terminals of the NH P2X7R-immunoreactivity was found to be localized in plasma membranes. Lastly, the role of P2X7R on AVP release was tested. Our results showed that BzATP evoked sustained AVP release in NH terminals, which was inhibited by AZ10606120. Taken together, our data lead us to conclude that the P2X7R is expressed in NH terminals and corroborates its role in AVP secretion.
Journal of cellular physiology.J Cell Physiol.2014 Mar;229(3):333-42. doi: 10.1002/jcp.24453.
Arginine-vasopressin (AVP) plays a major role in maintaining cardiovascular function and related pathologies. The mechanism involved in its release into the circulation is complex and highly regulated. Recent work has implicated the purinergic receptor, P2X7R, in a role for catecholamine-enhanced AV
PMID 24037803

Japanese Journal

Effects of retinoic acid on growth hormone-releasing hormone receptor, growth hormone secretagogue receptor gene expression and growth hormone secretion in rat anterior pituitary cells