scrapie prion protein

• スクレイピー異常プリオンタンパク質

関

PrP-res、PrPSc protein

WordNet

1. make into scrap or refuse; "scrap the old airplane and sell the parts"
2. a small piece of something that is left over after the rest has been used; "she jotted it on a scrap of paper"; "there was not a scrap left"
3. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
4. (microbiology) an infectious protein particle similar to a virus but lacking nucleic acid; thought to be the agent responsible for scrapie and other degenerative diseases of the nervous system
5. a fatal disease of sheep characterized by chronic itching and loss of muscular control and progressive degeneration of the central nervous system

PrepTutorEJDIC

1. 〈C〉『かけら』,小片;少し;《A~》少々(の…)《+『of』+『名』》 / 〈C〉《複数形で》残りもの,食べ残し / 〈U〉(くず鉄など)金属のスクラップ / 〈U〉『くず』,廃物,がらくた / (役に立たないとして)…‘を'捨てる(discard) / …‘を'くず(スクラップ)にする
2. (突然のちょっとした)いさかい,けんか / けんかする
3. 蛋白(たんばく)質

UpToDate Contents

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• 1. プリオンの生物学および遺伝学 biology and genetics of prions
• 2. プリオンによる中枢神経系疾患 diseases of the central nervous system caused by prions
• 3. 変異型クロイツフェルト・ヤコブ病 variant creutzfeldt jakob disease
• 4. クロイツフェルト・ヤコブ病 creutzfeldt jakob disease
• 5. アミロイド疾患の遺伝的要因 genetic factors in the amyloid diseases

English Journal

• Effect of Q211 and K222 PRNP Polymorphic Variants in the Susceptibility of Goats to Oral Infection With Goat Bovine Spongiform Encephalopathy.

• Aguilar-Calvo P1, Fast C2, Tauscher K2, Espinosa JC1, Groschup MH2, Nadeem M3, Goldmann W4, Langeveld J5, Bossers A5, Andreoletti O6, Torres JM1.
• The Journal of infectious diseases.J Infect Dis.2015 Aug 15;212(4):664-72. doi: 10.1093/infdis/jiv112. Epub 2015 Feb 26.
• BACKGROUND: The prion protein-encoding gene (PRNP) is one of the major determinants for scrapie occurrence in sheep and goats. However, its effect on bovine spongiform encephalopathy (BSE) transmission to goats is not clear.METHODS: Goats harboring wild-type, R/Q211 or Q/K222 PRNP genotypes were ora
• PMID 25722297

• Report of outbreaks of classical scrapie in Dorper sheep and associated prion protein gene polymorphisms in affected flocks.

• de Andrade CP1, de Oliveira EC, Leal JS, de Almeida LL, de Castro LA, da Silva SC, Driemeier D.
• Tropical animal health and production.Trop Anim Health Prod.2015 Aug;47(6):1203-12. doi: 10.1007/s11250-015-0849-9. Epub 2015 May 21.
• Scrapie is an infectious neurodegenerative disease affecting sheep and goats, related with conformational alteration of an isoform of the prion protein that leads to deposition and aggregation in the host's central nervous system. Occurrence of the natural disease can be influenced by host genetic f
• PMID 25995150

• Further characterisation of transmissible spongiform encephalopathy phenotypes after inoculation of cattle with two temporally separated sources of sheep scrapie from Great Britain.

• Konold T1, Nonno R2, Spiropoulos J3, Chaplin MJ4, Stack MJ5, Hawkins SA6, Cawthraw S7, Wilesmith JW8, Wells GA9, Agrimi U10, Di Bari MA11, Andréoletti O12, Espinosa JC13, Aguilar-Calvo P14, Torres JM15.
• BMC research notes.BMC Res Notes.2015 Jul 24;8(1):312.
• BACKGROUND: The infectious agent responsible for the bovine spongiform encephalopathy (BSE) epidemic in Great Britain is a transmissible spongiform encephalopathy (TSE) strain with uniform properties but the origin of this strain remains unknown. Based on the hypothesis that classical BSE may have b
• PMID 26205536

Japanese Journal

• Heterogeneity of Abnormal Prion Protein (PrP[Sc]) in Murine Scrapie Prions Determined by PrP[Sc]-Specific Monoclonal Antibodies

• The journal of veterinary medical science 76(2), 285-288, 2014-02
• NAID 40019993478

• Heterogeneity of Abnormal Prion Protein (PrPSc) in Murine Scrapie Prions Determined by PrPSc-Specific Monoclonal Antibodies

• Journal of Veterinary Medical Science 76(2), 285-288, 2014
• NAID 130003382358

• Therapeutic effect of peripheral administration of an anti-prion protein antibody on mice infected with prions

• Microbiology and immunology 57(4), 288-297, 2013-04
• NAID 40019646723

Related Links

• Scrapie prion protein accumulation by scrapie-infected ...

The “protein only” hypothesis proposes that the causative agent of transmissible spongiform encephalopathies, the prion, is identical with a conformational isoform of the cellular form of the prion protein (PrP C) (1). PrP C is a normal ...

• Scrapie prion protein accumulation by scrapie-infected ...

Figure 2 Anti-PrP antibody 6H4 and PIPLC prevent infection of N2a/Bos2 cell with scrapie prions and abrogate PrP Sc accumulation in chronically infected cells. (a) N2a/Bos2 cells were incubated for 2 h with antibody 6H4 or PIPLC at ...

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★リンクテーブル★

リンク元	「PrP-res」「PrPSc protein」「スクレイピー異常プリオンタンパク質」
関連記事	「scrap」「prion protein」「scrapie prion」

「PrP-res」

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スクレイピー異常プリオンタンパク質

関

PrPSc protein、scrapie agent、scrapie prion protein

「PrPSc protein」

　　[★]

• スクレイピー異常プリオンタンパク質

関

PrP-res、scrapie agent、scrapie prion protein

「スクレイピー異常プリオンタンパク質」

　　[★]

英

scrapie prion protein、PrPSc protein、PrP-res

関

スクレイピー病原体

「scrap」

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• n.

• いっぺん、小片、破片、切れっ端。[fig]僅少。抜粋。(書き物の)断片。[pl]食べ残し、残飯。くず、廃物、がらくた、スクラップ

• adj.

• 小片の、砕片の。くずの。残り物からなる

• vt.,vi.

　 　 　 　

「prion protein」

　　[★]

同

PrP

同

PrP

同

PrP

「scrapie prion」

　　[★]

• スクレイピープリオン