WordNet

make into scrap or refuse; "scrap the old airplane and sell the parts"
a small piece of something that is left over after the rest has been used; "she jotted it on a scrap of paper"; "there was not a scrap left"
(microbiology) an infectious protein particle similar to a virus but lacking nucleic acid; thought to be the agent responsible for scrapie and other degenerative diseases of the nervous system
a fatal disease of sheep characterized by chronic itching and loss of muscular control and progressive degeneration of the central nervous system

PrepTutorEJDIC

〈C〉『かけら』,小片;少し;《A~》少々(の…)《+『of』+『名』》 / 〈C〉《複数形で》残りもの,食べ残し / 〈U〉(くず鉄など)金属のスクラップ / 〈U〉『くず』,廃物,がらくた / (役に立たないとして)…‘を'捨てる(discard) / …‘を'くず(スクラップ)にする
(突然のちょっとした)いさかい,けんか / けんかする

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Anchorless forms of prion protein - Impact of truncation on structure destabilization and prion protein conversion.

Kovač V1, Hafner-Bratkovič I2, Čurin Šerbec V3.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2016 Dec 2;481(1-2):1-6. doi: 10.1016/j.bbrc.2016.11.036. Epub 2016 Nov 11.
Prion diseases are a group of fatal neurodegenerative diseases caused by scrapie form of prion protein, PrPSc. Prion protein (PrP) is bound to the cell via glycophosphatidylinositol (GPI) anchor. The role of GPI anchor in PrPSc replication and propagation remains unclear. It has been shown that anch
PMID 27836542

Cook RW1, Bingham J2, Besier AS3, Bayley CL4, Hawes M5, Shearer PL6, Yamada M2, Bergfeld J2, Williams DT2, Middleton DJ2.
Australian veterinary journal.Aust Vet J.2016 Dec;94(12):452-455. doi: 10.1111/avj.12529. Epub 2016 Nov 3.
BACKGROUND: Since its initial detection in Norway in 1998, atypical scrapie ('atypical/Nor98 scrapie') has been reported in sheep in the majority of European countries (including in regions free of classical scrapie) and in the Falkland Islands, the USA, Canada, New Zealand and Australia.CASE SERIES
PMID 27807855

Thackray AM1, Andreoletti O2, Bujdoso R1.
The Biochemical journal.Biochem J.2016 Dec 1;473(23):4399-4412. Epub 2016 Oct 12.
In pursuit of a tractable bioassay to assess blood prion infectivity, we have generated prion protein (PrP) transgenic Drosophila, which show a neurotoxic phenotype in adulthood after exposure to exogenous prions at the larval stage. Here, we determined the sensitivity of ovine PrP transgenic Drosop
PMID 27733649

Biological and Biochemical Characterization of Mice Expressing Prion Protein Devoid of the Octapeptide Repeat Region after Infection with Prions

Yamaguchi Yoshitaka,Miyata Hironori,Uchiyama Keiji,Ootsuyama Akira,Inubushi Sachiko,Mori Tsuyoshi,Muramatsu Naomi,Katamine Shigeru,Sakaguchi Suehiro
PLoS ONE 7(8), e43540, 2012-08-21
… Accumulating lines of evidence indicate that the N-terminal domain of prion protein (PrP) is involved in prion susceptibility in mice. … In this study, to investigate the role of the octapeptide repeat (OR) region alone in the N-terminal domain for the susceptibility and pathogenesis of prion disease, we intracerebrally inoculated RML scrapie prions into tg(PrPΔOR)/Prnp 0/0 mice, which express mouse PrP missing only the OR region on the PrP-null background. …
NAID 120005121768

Ultrasensitive detection of scrapie prion protein derived from ARQ and AHQ homozygote sheep by interspecies in vitro amplification

Retrospective Analysis of Sheep Scrapie by Western Blotting with Formalin-Fixed Paraffin-Embedded (FFPE) Tissues

DORJ Gantsetseg,OKADA Hiroyuki,MIYAZAWA Kohtaro [他],MASUJIN Kentaro,KIMURA Kumiko,MOHRI Shirou,YOKOYAMA Takashi
Journal of Veterinary Medical Science 74(9), 1207-1210, 2012
… An abnormal isoform of prion protein (PrPSc) was extracted from formalin-fixed paraffin-embedded (FFPE) tissues from sheep and analyzed by western blotting. … PrPSc immunoreactivity against anti-PrP monoclonal antibody T2, which recognizes discontinuous PrP sequences, differed amongst individual scrapie sheep cases. …
NAID 130001879749