WordNet
- the action of incorporating a racial or religious group into a community (同)integrating, desegregation
- an operation used in the calculus whereby the integral of a function is determined
PrepTutorEJDIC
- 統合,集成,完成 / (学校や住居における)人種差別の撤廃
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/17 01:35:55」(JST)
[Wiki en表示]
The pre-integration complex (PIC) is a nucleoprotein complex of viral genetic material and associated viral and host proteins which is capable of inserting a viral genome into a host genome. The PIC forms after uncoating of a viral particle after entry into the host cell. In the case of the human immunodeficiency virus (HIV), the PIC forms after the Reverse Transcription Complex (RTC) has reverse transcribed the viral RNA code into DNA code.[1] The PIC consists of viral proteins (including Vpr, matrix and integrase), host proteins (including Barrier to autointegration factor 1) and the viral DNA.[1] The PIC enters the cellular nucleus through the nuclear pore complex without disrupting the nuclear envelope, thus allowing HIV and related retroviruses to replicate in non-dividing cells.[2][3] Following nuclear entry, the PIC's DNA payload may be integrated into the host DNA as a "provirus".[4]
See also
- HIV
- Barrier to autointegration factor 1
External links
- http://www.mcld.co.uk/hiv/?q=preintegration%20complex
http://search.proquest.com/docview/224644188/fulltextPDF?accountid=14214#
References
- ^ a b Nathalie Arhel (2010) Revisiting HIV-1 uncoating, Retrovirology
- ^ Piller, S. C.; Caly, L.; Jans, D. A. (2003). "Nuclear import of the pre-integration complex (PIC): the Achilles heel of HIV?". Current drug targets 4 (5): 409–429. doi:10.2174/1389450033490984. PMID 12816349.
- ^ De Rijck, J.; Vandekerckhove, L.; Christ, F.; Debyser, Z. (2007). "Lentiviral nuclear import: a complex interplay between virus and host". BioEssays : news and reviews in molecular, cellular and developmental biology 29 (5): 441–451. doi:10.1002/bies.20561. PMID 17450594.
- ^ Smith, Johanna A.; Nunnari, Giuseppe; Preuss, Mirjam ; Pomerantz, Roger J.; Daniel, René (Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia) (2007). "Pentoxifylline Suppresses Transduction by HIV-1-Based Vectors". Intervirology 50 (5): 377–386. doi:10.1159/000109752. PMID 17938572.
UpToDate Contents
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English Journal
- Insights into the molecular and biological features of the dUTPase-related gene of bovine immunodeficiency virus.
- Podolny Y1, Herzig E1, Hizi A2.
- Virology.Virology.2017 Jun;506:55-63. doi: 10.1016/j.virol.2017.03.006. Epub 2017 Mar 22.
- PMID 28342388
- Retroviral intasomes arising.
- Engelman AN1, Cherepanov P2.
- Current opinion in structural biology.Curr Opin Struct Biol.2017 Apr 27;47:23-29. doi: 10.1016/j.sbi.2017.04.005. [Epub ahead of print]
- PMID 28458055
- A Computational Model for Predicting Integrase Catalytic Domain of Retrovirus.
- Wu S1, Han J1, Zhang X2, Zhong D1, Liu R1.
- Journal of theoretical biology.J Theor Biol.2017 Apr 25. pii: S0022-5193(17)30184-4. doi: 10.1016/j.jtbi.2017.04.020. [Epub ahead of print]
- PMID 28454901
Japanese Journal
- Transcription Profiling Demonstrates Epigenetic Control of Non-retroviral RNA Virus-Derived Elements in the Human Genome
- Outcomes in Two Japanese Adenosine Deaminase-Deficiency Patients Treated by Stem Cell Gene Therapy with No Cytoreductive Conditioning
- レトロウイルスベクターを用いた遺伝子治療:臨床治験での進展と安全性
Related Links
- Integration of retroviral DNA marks the multipotent progenitor cells that then give rise to the mature cell types of the hematopoietic lineage. Thus it is possible to investigate what types of progenitors can contribute to each ...
- 1. Adv Genet. 2005;55:147-81. Retroviral DNA integration--mechanism and consequences. Lewinski MK(1), Bushman FD. Author information: (1)Infectious Disease Laboratory, The Salk Institute for Biological ...
★リンクテーブル★
[★]
- 英
- retroviral integration
[★]
- 関
- built-in、integral、integrate、integrative、unified、unify
[★]
レトロウイルスの、レトロウイルス性の
- 関
- retrovirally、retrovirus