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English Journal

In vivo odourant response properties of migrating adult-born neurons in the mouse olfactory bulb.

Kovalchuk Y1, Homma R2, Liang Y1, Maslyukov A1, Hermes M1, Thestrup T3, Griesbeck O3, Ninkovic J4, Cohen LB5, Garaschuk O1.
Nature communications.Nat Commun.2015 Feb 19;6:6349. doi: 10.1038/ncomms7349.
Juxtaglomerular neurons (JGNs) of the mammalian olfactory bulb are generated throughout life. Their integration into the preexisting neural network, their differentiation and survival therein depend on sensory activity, but when and how these adult-born cells acquire responsiveness to sensory stimul
PMID 25695931

Genetically engineered mesenchymal stromal cells producing TNFα have tumour suppressing effect on human melanoma xenograft.

Tyciakova S1, Matuskova M, Bohovic R, Polakova K, Toro L, Skolekova S, Kucerova L.
The journal of gene medicine.J Gene Med.2015 Feb 10. doi: 10.1002/jgm.2823. [Epub ahead of print]
BACKGROUND: Mesenchymal stromal cells (MSC) are a promising tool for targeted cancer therapy due to their tumour-homing ability. Intrinsic resistance enables the MSC to longer tolerate therapeutic factors, such as prodrug converting enzymes, cytokines and pro-apoptotic proteins. Tumour necrosis fact
PMID 25677845

In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells.

Biasco L1, Scala S2, Basso Ricci L3, Dionisio F3, Baricordi C3, Calabria A3, Giannelli S3, Cieri N4, Barzaghi F5, Pajno R5, Al-Mousa H6, Scarselli A7, Cancrini C7, Bordignon C8, Roncarolo MG2, Montini E3, Bonini C4, Aiuti A9.
Science translational medicine.Sci Transl Med.2015 Feb 4;7(273):273ra13. doi: 10.1126/scitranslmed.3010314.
A definitive understanding of survival and differentiation potential in humans of T cell subpopulations is of paramount importance for the development of effective T cell therapies. In particular, uncovering the dynamics in vivo in humans of the recently described T memory stem cells (TSCM) would be
PMID 25653219