レチノイドX受容体β
WordNet
- to remain unmolested, undisturbed, or uninterrupted -- used only in infinitive form; "let her be"
- work in a specific place, with a specific subject, or in a specific function; "He is a herpetologist"; "She is our resident philosopher" (同)follow
- have life, be alive; "Our great leader is no more"; "My grandfather lived until the end of war" (同)live
- be identical to; be someone or something; "The president of the company is John Smith"; "This is my house"
- happen, occur, take place; "I lost my wallet; this was during the visit to my parents house"; "There were two hundred people at his funeral"; "There was a lot of noise in the kitchen"
- have the quality of being; (copula, used with an adjective or a predicate noun); "John is rich"; "This is not a good answer"
- occupy a certain position or area; be somewhere; "Where is my umbrella?" "The toolshed is in the back"; "What is behind this behavior?"
- spend or use time; "I may be an hour"
- stake on the outcome of an issue; "I bet $100 on that new horse"; "She played all her money on the dark horse" (同)wager, play
- the act of gambling; "he did it on a bet" (同)wager
- maintain with or as if with a bet; "I bet she will be there!" (同)wager
- second in order of importance; "the candidate, considered a beta male, was perceived to be unable to lead his party to victory"
- the 2nd letter of the Greek alphabet
- preliminary or testing stage of a software or hardware product; "a beta version"; "beta software"
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- the 24th letter of the Roman alphabet (同)x, ex
PrepTutorEJDIC
- 《連結語として補語を伴なって…『である』,…だ,…です / 《位置・場所を表す語句を伴って》(…に)『ある』,いる(occupy a place or situation) / 〈物事が〉『存在する』,ある(exist);〈生物が〉生存する,生きている(live) / 行われる,起こる,発生する(take place, occur) / 存続する,そのままでいる(remain as before) / 《『be to』 do》 / …する予定である,…することになっている / …すべきだ / 《受動態の不定詞を伴って》…できる / 《命令》…するのだ / 《条件節に》…する意図がある / 《『if…were to』 do》…するとしたなら / 《『be』 do『ing』》《進行形》 / 《進行中の動作》…している,しつつある / 《近い未来》…しようとしている,するつもり / 《動作の反復》(いつも)…している / 《『be』+『他動詞の過去分詞』》《受動態》…される,されている / 《『be』+『自動詞の過去分詞』》《完了形》…した[状態にある]
- 『かけ』・(…との)かけ《+『with』+『名』》 / かけた物(金) / かけの対象 / 〈金・物〉'を'『かける』 / (かけ事・ゲームなどで)〈人〉‘と'『かけをする』《+『名』〈人〉+『on』+『名』》 / (…に)『かける』《+『on』(『against』)+『名』(one's do『ing』)》
- ベータ(ギリシア語アルファベットの第2文字;B,β;英語のB,b に遭当)
- =sense organ / 受信装置
- Christ / Christian
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/11/05 09:45:24」(JST)
[Wiki en表示]
Retinoid X receptor, beta |
PDB rendering based on 1by4. |
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
1H9U, 1UHL
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Identifiers |
Symbols |
RXRB ; DAUDI6; H-2RIIBP; NR2B2; RCoR-1 |
External IDs |
OMIM: 180246 MGI: 98215 HomoloGene: 7923 IUPHAR: NR2B2 ChEMBL: 1870 GeneCards: RXRB Gene |
Gene ontology |
Molecular function |
• RNA polymerase II regulatory region sequence-specific DNA binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
• sequence-specific DNA binding transcription factor activity
• steroid hormone receptor activity
• transcription coactivator activity
• ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
• 9-cis retinoic acid receptor activity
• protein binding
• zinc ion binding
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Cellular component |
• nucleus
• nucleoplasm
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Biological process |
• in utero embryonic development
• maternal placenta development
• transcription initiation from RNA polymerase II promoter
• gene expression
• steroid hormone mediated signaling pathway
• positive regulation of transcription from RNA polymerase II promoter
• retinoic acid receptor signaling pathway
• ventricular cardiac muscle cell differentiation
• cardiac muscle cell proliferation
• cellular response to retinoic acid
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
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Entrez |
6257 |
20182 |
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Ensembl |
ENSG00000204231 |
ENSMUSG00000039656 |
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UniProt |
P28702 |
P28704 |
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RefSeq (mRNA) |
NM_001270401 |
NM_001205214 |
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RefSeq (protein) |
NP_001257330 |
NP_001192143 |
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Location (UCSC) |
Chr 6:
33.16 – 33.17 Mb |
Chr 17:
34.03 – 34.04 Mb |
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PubMed search |
[1] |
[2] |
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Retinoid X receptor beta (RXR-beta), also known as NR2B2 (nuclear receptor subfamily 2, group B, member 2) is a nuclear receptor that in humans is encoded by the RXRB gene.[1][2]
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.[2]
Contents
- 1 Interactive pathway map
- 2 See also
- 3 References
- 4 Further reading
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
[[File:
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Vitamin D Synthesis Pathway edit
- ^ The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531".
See also
References
- ^ Fitzgibbon J, Gillett GT, Woodward KJ, Boyle JM, Wolfe J, Povey S (July 1993). "Mapping of RXRB to human chromosome 6p21.3". Ann. Hum. Genet. 57 (Pt 3): 203–9. doi:10.1111/j.1469-1809.1993.tb01596.x. PMID 8257090.
- ^ a b "Entrez Gene: RXRB retinoid X receptor, beta".
Further reading
- Szanto A, Narkar V, Shen Q, et al. (2005). "Retinoid X receptors: X-ploring their (patho)physiological functions.". Cell Death Differ. 11 Suppl 2: S126–43. doi:10.1038/sj.cdd.4401533. PMID 15608692.
- Leid M, Kastner P, Lyons R, et al. (1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.". Cell 68 (2): 377–95. doi:10.1016/0092-8674(92)90478-U. PMID 1310259.
- Fleischhauer K, Park JH, DiSanto JP, et al. (1992). "Isolation of a full-length cDNA clone encoding a N-terminally variant form of the human retinoid X receptor beta". Nucleic Acids Res. 20 (7): 1801. doi:10.1093/nar/20.7.1801. PMC 312273. PMID 1315958.
- Berrodin TJ, Marks MS, Ozato K, et al. (1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein". Mol. Endocrinol. 6 (9): 1468–78. doi:10.1210/me.6.9.1468. PMID 1331778.
- Epplen C, Epplen JT (1992). "The human cDNA sequence homologous to the mouse MHC class I promoter-binding protein gene contains four additional codons in lymphocytes". Mamm. Genome 3 (8): 472–5. doi:10.1007/BF00356161. PMID 1514958.
- Yu VC, Delsert C, Andersen B, et al. (1992). "RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements". Cell 67 (6): 1251–66. doi:10.1016/0092-8674(91)90301-E. PMID 1662118.
- Oñate SA, Tsai SY, Tsai MJ, O'Malley BW (1995). "Sequence and characterization of a coactivator for the steroid hormone receptor superfamily". Science 270 (5240): 1354–7. doi:10.1126/science.270.5240.1354. PMID 7481822.
- Kooistra T, Lansink M, Arts J, et al. (1995). "Involvement of retinoic acid receptor alpha in the stimulation of tissue-type plasminogen-activator gene expression in human endothelial cells". Eur. J. Biochem. 232 (2): 425–32. doi:10.1111/j.1432-1033.1995.425zz.x. PMID 7556191.
- Perlmann T, Jansson L (1995). "A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1". Genes Dev. 9 (7): 769–82. doi:10.1101/gad.9.7.769. PMID 7705655.
- Forman BM, Umesono K, Chen J, Evans RM (1995). "Unique response pathways are established by allosteric interactions among nuclear hormone receptors". Cell 81 (4): 541–50. doi:10.1016/0092-8674(95)90075-6. PMID 7758108.
- Zanaria E, Muscatelli F, Bardoni B, et al. (1995). "An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita". Nature 372 (6507): 635–41. doi:10.1038/372635a0. PMID 7990953.
- Almasan A, Mangelsdorf DJ, Ong ES, et al. (1994). "Chromosomal localization of the human retinoid X receptors". Genomics 20 (3): 397–403. doi:10.1006/geno.1994.1193. PMID 8034312.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Fleischhauer K, McBride OW, DiSanto JP, et al. (1993). "Cloning and chromosome mapping of human retinoid X receptor beta: selective amino acid sequence conservation of a nuclear hormone receptor in mammals". Hum. Genet. 90 (5): 505–10. doi:10.1007/BF00217449. PMID 8381386.
- May M, Mengus G, Lavigne AC, et al. (1996). "Human TAF(II28) promotes transcriptional stimulation by activation function 2 of the retinoid X receptors". EMBO J. 15 (12): 3093–104. PMC 450252. PMID 8670810.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Joyeux A, Cavaillès V, Balaguer P, Nicolas JC (1997). "RIP 140 enhances nuclear receptor-dependent transcription in vivo in yeast". Mol. Endocrinol. 11 (2): 193–202. doi:10.1210/me.11.2.193. PMID 9013766.
- Xu XC, Sozzi G, Lee JS, et al. (1997). "Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development". J. Natl. Cancer Inst. 89 (9): 624–9. doi:10.1093/jnci/89.9.624. PMID 9150186.
- Chen H, Lin RJ, Schiltz RL, et al. (1997). "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300". Cell 90 (3): 569–80. doi:10.1016/S0092-8674(00)80516-4. PMID 9267036.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
PDB gallery
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1by4: STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA
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1dsz: STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1
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1h9u: THE STRUCTURE OF THE HUMAN RETINOID-X-RECEPTOR BETA LIGAND BINDING DOMAIN IN COMPLEX WITH THE SPECIFIC SYNTHETIC AGONIST LG100268
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1r0n: Crystal Structure of Heterodimeric Ecdsyone receptor DNA binding complex
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1rxr: HIGH RESOLUTION SOLUTION STRUCTURE OF THE RETINOID X RECEPTOR DNA BINDING DOMAIN, NMR, 20 STRUCTURE
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1uhl: Crystal structure of the LXRalfa-RXRbeta LBD heterodimer
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2nll: RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
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UpToDate Contents
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English Journal
- Expression of retinoid X receptor beta is induced in astrocytes during corpus callosum demyelination.
- König R, Stillfried M, Aperdannier P, Clarner T, Beyer C, Kipp M, Mey J.SourceInstitut für Biologie II, RWTH Aachen, Germany.
- Journal of chemical neuroanatomy.J Chem Neuroanat.2012 Mar;43(2):120-32. doi: 10.1016/j.jchemneu.2012.01.002. Epub 2012 Jan 28.
- The experimental activation of retinoid receptors reduces pathological symptoms in animal models of multiple sclerosis. In order to assess the involvement of endogenous retinoid signaling during the process of demyelination we investigated retinoic acid synthesizing enzymes and nuclear receptors usi
- PMID 22306550
- Computational studies of LXR molecular interactions reveal an allosteric communication pathway.
- Burendahl S, Nilsson L.SourceDepartment of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
- Proteins.Proteins.2012 Jan;80(1):294-306. doi: 10.1002/prot.23209. Epub 2011 Nov 9.
- The liver X receptor, LXRα, is an important regulator of genes involved in metabolism and inflammation. The mechanism of communication between the cofactor peptide and the ligand in the ligand-binding pocket is a crucial and often discussed issue for the nuclear receptors (NRs), but such allosteric
- PMID 22072626
Japanese Journal
- Tamibarotene: A Candidate Retinoid Drug for Alzheimer's Disease
- Honokiol increases ABCA1 expression level by activating retinoid X receptor beta
- Honokiol Increases ABCA1 Expression Level by Activating Retinoid X Receptor Beta
Related Links
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- retinoid X receptor beta 2,19 Mouse 520 17 18.49 cM Rxrb retinoid X receptor beta 12,15,18-19,21 Rat 518 20p12 Rxrb retinoid X receptor 35 Previous and Unofficial Database Links Specialist databases 10.1621/C1NLY8682M ...
★リンクテーブル★
[★]
- 英
- retinoid X receptor beta
[★]
キサントシン, xanthosine
[★]
β、ベータ
[★]