receptor editing

関

B cell＆development

WordNet

1. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
2. putting something (as a literary work or a legislative bill) into acceptable form (同)redaction

PrepTutorEJDIC

1. =sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/04/12 02:35:13」(JST)

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Receptor editing is a process that occurs during the maturation of B cells, which are part of the adaptive immune system. This process forms part of central tolerance to attempt to change the specificity of the antigen receptor of self reactive immature B-cells, in order to rescue them from programmed cell death, called apoptosis. It is thought that 20-50% of all peripheral naive B cells have undergone receptor editing making it the most common method of removing self reactive B cells.

During maturation in the bone marrow, B cells are tested for interaction with self antigens, which is called negative selection. If the maturing B cells strongly interact with these self antigens, they undergo death by apoptosis. Negative selection is important to avoid the production of B cells that could cause autoimmune diseases. They can avoid apoptosis by modifying the sequence of light chain V and J genes (components of the antigen receptor) so that it has a different specificity and may not recognize self antigens anymore. This process of changing the specificity of the immature B cell receptor is called receptor editing.

References

    3. Kleinfield R, Hardy RR, Tarlinton, D (1986). 'Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a          
Ly1+ B-cell lymphoma'. Nature 322 (6082): 843-6.

UpToDate Contents

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• 1. T細胞受容体の遺伝学 t cell receptor genetics
• 2. インスリン受容体の構造および機能 structure and function of the insulin receptor
• 3. 免疫不全症を引き起こすCD3／T細胞受容体複合体疾患 cd3 t cell receptor complex disorders causing immunodeficiency
• 4. BおよびTリンパ球の正常な発生 normal b and t lymphocyte development
• 5. T細胞受容体シグナル伝達 t cell receptor signaling

English Journal

• New applications of CRISPR/Cas9 system on mutant DNA detection.

• Jia C1, Huai C1, Ding J1, Hu L1, Su B2, Chen H3, Lu D4.
• Gene.Gene.2018 Jan 30;641:55-62. doi: 10.1016/j.gene.2017.10.023. Epub 2017 Oct 12.
• PMID 29031777

• TALENs-mediated homozygous CCR5Δ32 mutations endow CD4+ U87 cells with resistance against HIV‑1 infection.

• Yu AQ1, Ding Y1, Lu ZY1, Hao YZ2, Teng ZP2, Yan SR1, Li DS1, Zeng Y2.
• Molecular medicine reports.Mol Med Rep.2018 Jan;17(1):243-249. doi: 10.3892/mmr.2017.7889. Epub 2017 Oct 26.
• PMID 29115572

• Osteoprotection Through the Deletion of the Transcription Factor Rorβ in Mice.

• Farr JN1,2, Weivoda MM1,2, Nicks KM1, Fraser DG1, Negley BA1, Onken JL1, Thicke BS1, Ruan M1, Liu H3, Forrest D3, Hawse JR4, Khosla S1,2, Monroe DG1,2.
• Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.J Bone Miner Res.2017 Dec 5. doi: 10.1002/jbmr.3351. [Epub ahead of print]
• PMID 29206307

Japanese Journal

• 1P-006 Gタンパク質共役型受容体の二量体形成検出のためのゲノム編集技術の開発(遺伝子工学,一般講演)

• 日本生物工学会大会講演要旨集 66, 18, 2014-08-05
• NAID 110009906087

• Serotonin 2C Receptor as a Superhero: Diversities and Talents in the RNA Universe for Editing, Variant, Small RNA and Other Expected Functional RNAs

• Journal of Pharmacological Sciences, 321-328, 2014
• NAID 130004933183

• TDP-43病理形成メカニズムにおけるTDP-43のカルパイン依存性断片化の意義

• 臨床神経学 54(12), 1151-1154, 2014
• NAID 130004921169

Related Links

• www.rs.noda.tus.ac.jp

抗原受容体(B cell receptor: BCR)が抗原に出会うと、B細胞は抗体産生細胞か記憶細胞に分化して免疫応答に活躍します。ここでも、細胞の活性化、様々な蛋白の発現、細胞増殖あるいはアポトーシス、そして分化方向の決定と、様々な ...

• B cell receptor editing in tolerance and autoimmunity

At the outset one might ask, why edit? The major biological justification for the existence of receptor editing is likely to be the elimination of self-reactive B cells and the prevention of autoimmune manifestations. In mice expressing the ...

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関連記事

「editing」

「editing」

　　[★]

• n.

• 編集、エディティング

関

compilation、compile、edit