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Heart rate variability in conscious and anesthetized rats under the action of angiotensin converting enzyme inhibitors.

Fateev MM, Sidorov AV, Grigor'eva MV, Rakov AA, Fateeva KM.SourceDepartment of Normal Physiology and Biophysics, Department of Pharmacology, Yaroslavl State Medical Academy, Russia. fateev52@mail.ru
Bulletin of experimental biology and medicine.Bull Exp Biol Med.2012 Mar;152(5):590-4.
We studied the effects of three various angiotensin converting enzyme inhibitors (enalapril, lisinopril and quinapril) on heart rhythm variability in anesthetized and immobilized rats. In all cases (except for quinapril in experiments on anesthetized animals), the preparations reduced the total rhyt
PMID 22803141

Chen L, Kim SM, Eisner C, Oppermann M, Huang Y, Mizel D, Li L, Chen M, Sequeira Lopez ML, Weinstein LS, Gomez RA, Schnermann J, Briggs JP.SourceNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Building 31, Room 2B11, Bethesda, MD 20892, USA.
Journal of the American Society of Nephrology : JASN.J Am Soc Nephrol.2010 Jun;21(6):986-92. doi: 10.1681/ASN.2009030307. Epub 2010 Apr 15.
Angiotensin II converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB) presumably stimulate renin secretion by interrupting angiotensin II feedback inhibition. The increase in cytosolic calcium caused by activation of Gq-coupled AT1 receptors may mediate the renin-inhibitory ef
PMID 20395378

Quinaprilat: a review of its pharmacokinetics, pharmacodynamics, toxicological data and clinical application.

Kieback AG, Felix SB, Reffelmann T.SourceUniversitätsklinikum Greifswald, Klinik für Innere Medizin B, Friedrich-Loeffler-Str. 23a, 17475 Greifswald, Germany. arne.kieback@uni-greifswald.de
Expert opinion on drug metabolism & toxicology.Expert Opin Drug Metab Toxicol.2009 Oct;5(10):1337-47. doi: 10.1517/17425250903282773.
BACKGROUND: Quinaprilat is an ACE inhibitor for intravenous use especially in patients with arterial hypertension or chronic heart failure. In contrast to the oral prodrug quinapril, it has not been approved for clinical application.OBJECTIVE: In this review, the pharmacokinetic and pharmacodynamic
PMID 19761414

Simultaneous determination of hydrochlorothiazide, quinapril and quinaprilat in human plasma by liquid chromatography-tandem mass spectrometry

PAREKH Sagar A.,PUDAGE Ashutosh,JOSHI Santosh S.,VAIDYA Vikas V.,GOMES Noel A.,KAMAT Sudhir S.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 873(1), 59-69, 2008-09-15
NAID 10028006496

Elimination Kinetics of Quinaprilat and Perindoprilat in Hypertensive Patients with Renal Failure on Haemodialysis

Yamada Shigeki,Muraoka Isao,Kato Kana [他],HIROMI Yoko,TAKASU Rie,SENO Hachiro,KAWAHARA Hirohisa,NABESHIMA Toshitaka
Biological & pharmaceutical bulletin 26(6), 872-875, 2003-06-01
… Objective of the present study was to investigate the elimination kinetics of quinaprilat and perindoprilat, the active metabolites of angiotensin-converting enzyme (ACE) inhibitors quinapril and perindopril, in hypertensive patients with renal failure under haemodialysis to evaluate the appropriate duration of off-dose of these drugs before starting of low-density lipoprotein (LDL) apheresis. …
NAID 110003608535

Protective Effects of Quinaprilat and Trandolaprilat, Active Metabolites of Quinapril and Trandolapril, on Hemolysis Induced by Lysophosphatidylcholine in Human Erythrocytes

Hayase Nobumasa,Satomi Machiko,Hara Akiyoshi [他],AWAYA Tochio,SHIMIZU Keiko,MATSUBARA Kazuo
Biological & pharmaceutical bulletin 26(5), 712-716, 2003-05-01
… We examined the effects of the angiotensin converting enzyme (ACE) inhibitors captopril, enalaprilat, quinapril, and trandolapril, and their active metabolites quinaprilat and trandolaprilat, on hemolysis induced by lysophosphatidylcholine (LPC) in human erythrocytes. … Similarly, quinaprilat (10μ_M) and trandolaprilat (10, 100μ_M) significantly attenuated the LPC-induced hemolysis, but other ACE inhibitors did not. …
NAID 110003608503

Pillbox - National Library of Medicine Images of only legal Accupril

リンク元	「キナプリラト」「キナプリラート」
関連記事	「quinapril」

Quinaprilat
Systematic (IUPAC) name
	(3S)-2-[(2S)-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}propanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	82768-85-2
ATC code	?
UNII	34SSX5LDE5
ChEMBL	CHEMBL1733
Synonyms	CI-928
Chemical data
Formula	C23H26N2O5
Mol. mass	410.46294
	SMILES C[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N2Cc3ccccc3C[C@H]2C(=O)O;
	InChI InChI=InChI=1S/C23H26N2O5/c1-15(24-19(22(27)28)12-11-16-7-3-2-4-8-16)21(26)25-14-18-10-6-5-9-17(18)13-20(25)23(29)30/h2-10,15,19-20,24H,11-14H2,1H3,(H,27,28)(H,29,30)/t15-,19-,20-/m0/s1; Key:FLSLEGPOVLMJMN-YSSFQJQWSA-N ;