WordNet

antihistamine used to treat rhinitis and pruritus

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/05/12 19:49:12」(JST)

wiki en

Mepyramine, also known as pyrilamine, is a first generation antihistamine, targeting the H₁ receptor.^[1] However, it rapidly permeates the brain often causing drowsiness. It also has anticholinergic properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms.^[2] It is also the active ingredient of the topical antihistamine creams Anthisan and Neoantergan, sold for the treatment of insect bites, stings and nettle rash.

References

^ Parsons, Mike E.; Ganellin, C. Robin (January 2006). "Histamine and its receptors". British Journal of Pharmacology 147 (S1): S127–S135. doi:10.1038/sj.bjp.0706440. PMC 1760721. PMID 16402096. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1760721.
^ Active Ingredients for Midol Complete

This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.

This dermatologic drug article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 経口補水療法 oral rehydration therapy

English Journal

Histamine infused into basolateral amygdala enhances memory consolidation of inhibitory avoidance.

Benetti F, Izquierdo I.SourceCentro de Memória, Instituto do Cérebro (InsCER), Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP).Int J Neuropsychopharmacol.2013 Aug;16(7):1539-45. doi: 10.1017/S1461145712001514. Epub 2013 Jan 11.
The role of the basolateral amygdala (BLA) in the consolidation of aversive memory is well established. Here we investigate the involvement of the histaminergic system in BLA on this variable. Rats were chronically implanted with bilateral cannulae in the BLA and after recovery were trained in a one
PMID 23308396

The role of histamine receptors in the consolidation of object recognition memory.

da Silveira CK, Furini CR, Benetti F, Monteiro Sda C, Izquierdo I.SourceUniversidade Federal de Ciências da Saúde de Porto Alegre, RS 90050-170, Brazil.
Neurobiology of learning and memory.Neurobiol Learn Mem.2013 Jul;103:64-71. doi: 10.1016/j.nlm.2013.04.001. Epub 2013 Apr 9.
Findings have shown that histamine receptors in the hippocampus modulate the acquisition and extinction of fear motivated learning. In order to determine the role of hippocampal histaminergic receptors on recognition memory, adult male Wistar rats with indwelling infusion cannulae stereotaxically pl
PMID 23583502

Japanese Journal

増悪化アレルギー性皮膚炎症におけるヒスタミンの役割

平澤典保,大内和雄
YAKUGAKU ZASSHI 131(2), 179-184, 2011
… In this model, the PiCl-induced increase in the thickness of the earlobe in the immediate phase was suppressed by the histamine H1 antagonist pyrilamine. … The inhibitory effect of the combined treatment with pyrilamine and thioperamide on TPA-modified contact dermatitis was as potent as that of cyclosporin A. …
NAID 130000451447

Agarwood Induced Laxative Effects via Acetylcholine Receptors on Loperamide-Induced Constipation in Mice

KAKINO Mamoru,IZUTA Hiroshi,ITO Tetsuro,TSURUMA Kazuhiro,ARAKI Yoko,SHIMAZAWA Masamitsu,OYAMA Masayoshi,IINUMA Munekazu,HARA Hideaki
Bioscience, biotechnology, and biochemistry 74(8), 1550-1555, 2010-08-23
… EEA-1, but not senna, also increased the intestinal tension of isolated jejunum and ileum in guinea pigs, and the tension increase was blocked by atropine, a muscarinic receptor antagonist, but not by other inhibitors (granicetron, pyrilamine, or bradykinin-antagonist peptide). …
NAID 10027557930

Related Pictures

★リンクテーブル★

リンク元	「メピラミン」「ピリラミン」

「メピラミン」

Mepyramine
Systematic (IUPAC) name
	N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a606008
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	91-84-9 ; 59-33-6 (maleate)
ATC code	R06AC01 D04AA02
PubChem	CID 4992
IUPHAR ligand	1220
DrugBank	DB06691
ChemSpider	4818
UNII	HPE317O9TL
KEGG	D08183
ChEBI	CHEBI:6762
ChEMBL	CHEMBL511
Synonyms	N-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine
Chemical data
Formula	C17H23N3O
Mol. mass	285.38 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C17H23N3O/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15/h4-11H,12-14H2,1-3H3 ; Key:YECBIJXISLIIDS-UHFFFAOYSA-N ;
(what is this?) (verify);