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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/04 18:05:01」(JST)

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Mepyramine, also known as pyrilamine, is a first generation antihistamine, targeting the H₁ receptor.^[1] However, it rapidly permeates the brain often causing drowsiness. It also has anticholinergic properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms.^[2] It is also the active ingredient of the topical antihistamine creams Anthisan and Neoantergan, sold for the treatment of insect bites, stings, and nettle rash.

References

^ Parsons, Mike E.; Ganellin, C. Robin (January 2006). "Histamine and its receptors". British Journal of Pharmacology 147 (S1): S127–S135. doi:10.1038/sj.bjp.0706440. PMC 1760721. PMID 16402096.
^ Active Ingredients for Midol Complete

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English Journal

Tityus serrulatus venom increases vascular permeability in selected airway tissues in a mast cell-independent way.

Zuliani JP, Freitas TA, Conceição IM, Kwasniewski FH.SourceLaboratório de Farmacologia, Instituto Butantan, Av. Vital Brasil 1500, Butantan 05503-900, São Paulo, São Paulo, Brazil.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie.Exp Toxicol Pathol.2013 Mar;65(3):229-34. doi: 10.1016/j.etp.2011.08.010. Epub 2011 Sep 15.
Tityus serrulatus venom (Tsv)-induced pulmonary edema can occur in severe envenomation and the mechanisms involved are not completely understood. Therefore, we studied the effect of pharmacological modulation of the mast cell activation and the histamine antagonism on airways edema (investigated by
PMID 21920722

Histamine at low concentrations aggravates rat liver BRL-3A cell injury induced by hypoxia/reoxygenation through histamine H2 receptor in vitro.

Wu T, Gan X, Zhou S, Ge M, Zhang Z, Hei Z.SourceDepartment of Anesthesiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2013 Feb;27(1):378-86. doi: 10.1016/j.tiv.2012.07.014. Epub 2012 Aug 17.
AIM: Histamine released from mast cell degranulation participates in the pathogenesis of ischemia/reperfusion injury. The purpose of our study was to define the role of histamine in hypoxia/reoxygenation mediated liver cell injury and to elucidate the underlying mechanism in vitro.METHODS: Histamine
PMID 22926047

Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model.

Shimomura K, Okura T, Kato S, Couraud PO, Schermann JM, Terasaki T, Deguchi Y.SourceDepartment of Drug Disposition and Pharmacokinetics, School of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan. deguchi@pharm.teikyo-u.ac.jp.
Fluids and barriers of the CNS.Fluids Barriers CNS.2013 Jan 26;10(1):8. doi: 10.1186/2045-8118-10-8.
ABSTRACT:BACKGROUND: Knowledge of the molecular basis and transport function of the human blood-brain barrier (BBB) is important for not only understanding human cerebral physiology, but also development of new central nervous system (CNS)-acting drugs. However, few studies have been done using huma
PMID 23351963

Japanese Journal

The Affinity of Histamine for Gq Protein-Coupled Histamine H₁-Receptors Is Predominantly Regulated by Their Internalization in Human Astrocytoma Cells

Journal of pharmacological sciences 119(3), 233-242, 2012-07-20
NAID 10030986893

Inverse Agonistic Activity of Antihistamines and Suppression of Histamine H₁ Receptor Gene Expression

Journal of pharmacological sciences 118(1), 117-121, 2012-01-20
NAID 10030454416

Artificial Neural Network Combined with Principal Component Analysis for Resolution of Complex Pharmaceutical Formulations

Chemical and Pharmaceutical Bulletin 59(1), 35-40, 2011
NAID 130000405485

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リンク元	「メピラミン」「ピリラミン」

「メピラミン」

Mepyramine
Systematic (IUPAC) name
	N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a606008
Legal status	?
Identifiers
CAS number	91-84-9 ; 59-33-6 (maleate)
ATC code	R06AC01 D04AA02
PubChem	CID 4992
IUPHAR ligand	1220
DrugBank	DB06691
ChemSpider	4818
UNII	HPE317O9TL
KEGG	D08183
ChEBI	CHEBI:6762
ChEMBL	CHEMBL511
Synonyms	N-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine
Chemical data
Formula	C17H23N3O
Mol. mass	285.38 g/mol
	SMILES O(c1ccc(cc1)CN(c2ncccc2)CCN(C)C)C;
	InChI InChI=1S/C17H23N3O/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15/h4-11H,12-14H2,1-3H3 ; Key:YECBIJXISLIIDS-UHFFFAOYSA-N ;
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