pulmonary interstitial emphysema

同

PIE

WordNet

1. an abnormal condition of the lungs marked by decreased respiratory function; associated with smoking or chronic bronchitis or old age (同)pulmonary_emphysema
2. of or relating to interstices

PrepTutorEJDIC

1. 気腫(きしゅ),肺気腫
2. 肺の;肺を冒す

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/31 14:07:20」(JST)

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Pulmonary interstitial emphysema
Chest radiography showing severe pulmonary interstitial emphysema
Classification and external resources
Specialty	pediatrics
ICD-10	P25.0
ICD-9-CM	518.1
eMedicine	ped/

Pulmonary interstitial emphysema (PIE) is a collection of air outside of the normal air passages in the body and instead is found inside the connective tissue of the peribronchovascular sheaths, interlobular septa, and visceral pleura. (This supportive tissue is called the pulmonary interstitium.) This collection of air, develops as a result of alveolar and terminal bronchiolar rupture. Pulmonary interstitial emphysema is more frequent in premature infants who require mechanical ventilation for severe lung disease. Infants suffering from pulmonary interstitial emphysema are typically recommended for admission to a neonatal intensive care unit.

Pathophysiology

Pulmonary interstitial emphysema is created when air bursts or ruptures through tissue from the alveoli and bronchioles into the perivascular tissue of the lung.

Etiology

Pulmonary interstitial emphysema is a concern in any of the following diagnosis:

• Prematurity
• Respiratory distress syndrome (RDS)
• Meconium aspiration syndrome (MAS)
• Amniotic fluid aspiration
• Sepsis, or other infections
• Mechanical ventilation

Epidemiology

United States

The prevalence of pulmonary interstitial emphysema widely varies with the population studied. In a 1987 study 3% of infants admitted to the neonatal intensive care unit (NICU) developed pulmonary interstitial emphysema.

International

Studies reflecting international frequency demonstrated that 2-3% of all infants in NICUs develop pulmonary interstitial emphysema. When limiting the population studied to premature infants, this frequency increases to 20-30%, with the highest frequencies occurring in infants weighing fewer than 1000 g.

Prognosis

Pulmonary interstitial emphysema often resolves gradually and may take 2-3 weeks. For longer durations of PIE the length of time of mechanical ventilation needed may increase and the incidence of bronchopulmonary dysplasia becomes higher. Some infants may develop chronic lobar emphysema, which may require surgical lobectomies.

Treatment

Different treatments have been used to manage pulmonary interstitial emphysema with variable success. Admission/transfer to a neonatal intensive care unit (NICU) is common and expected for patients with PIE. Treatments include:

• Lateral decubitus position with the affected side down
• High-frequency ventilation
• Lobectomy
• Selective Main Bronchial Intubation and Occlusion

See also

• Bronchopulmonary dysplasia

References

UpToDate Contents

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• 1. 新生児における肺のエアリーク pulmonary air leak in the newborn
• 2. 早産児における呼吸窮迫症候群の予防および治療 prevention and treatment of respiratory distress syndrome in preterm infants
• 3. 新生児における機械的人工換気 mechanical ventilation in neonates
• 4. 機械的人工換気中の肺気圧障害 pulmonary barotrauma during mechanical ventilation
• 5. 先天性肺葉性肺気腫 congenital lobar emphysema

English Journal

• Exacerbation of combined pulmonary fibrosis and emphysema syndrome during tocilizumab therapy for rheumatoid arthritis.

• Wendling D, Vidon C, Godfrin-Valnet M, Rival G, Guillot X, Prati C.SourceService de rhumatologie, CHRU de Besançon, boulevard Fleming, 25030 Besançon, France. Electronic address: dwendling@chu-besancon.fr.
• Joint, bone, spine : revue du rhumatisme.Joint Bone Spine.2013 Dec;80(6):670-1. doi: 10.1016/j.jbspin.2013.03.009. Epub 2013 Apr 23.
• PMID 23618802

• Pulmonary interstitial emphysema after resolution of relapsing pneumothorax and discontinuation of mechanical ventilation. An atypical case in a preterm infant.

• Corsini I, Pratesi S, Dani C.SourceDepartment of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Florence, Italy.
• The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.J Matern Fetal Neonatal Med.2013 Nov 19. [Epub ahead of print]
• Abstract Pulmonary interstitial emphysema (PIE) is a frequent complication in preterm ventilated infants. These newborns have an increased risk of mortality and bronchopulmonary dysplasia. Various treatments for PIE have been proposed: high-frequency ventilation, postural therapy, selective bronchia
• PMID 24245490

• Tobacco Smoke-Induced Lung Fibrosis and Emphysema.

• Morse D, Rosas IO.SourceDivision of Pulmonary and Critical Care, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
• Annual review of physiology.Annu Rev Physiol.2013 Nov 18. [Epub ahead of print]
• Despite public health campaigns discouraging smoking, 1,000 American children every day become smokers, ensuring that tobacco-related health complications will be with us for decades to come. Smoking is the greatest risk factor for both chronic obstructive lung disease and interstitial lung disease.
• PMID 24274738

Japanese Journal

• 気腫合併肺線維症に併発した肺癌に対して外科的治療を行った27例の臨床的検討

• 溝上 裕子,増永 愛子,小嶋 圭介 [他]
• 日本呼吸器学会誌 = Annals of the Japanese Respiratory Society 4(5), 343-351, 2015-09-10
• NAID 40020592735

• Pathological and radiological correlation in an autopsy case of combined pulmonary fibrosis and emphysema

• Karata Hiroki,Tanaka Tomonori,Egashira Ryoko,Tabata Kazuhiro,Otani Kyoko,Hayashi Ryuji,Hori Takashi,Fukuoka Junya
• International Journal of Chronic Obstructive Pulmonary
• … We report an educational autopsy case of combined pulmonary fibrosis and emphysema. … Radiological patterns of the upper lung were considered as mostly emphysema, but pathological observation revealed significant interstitial fibrosis of usual interstitial pneumonia as a major pathology. … The patient eventually developed acute exacerbation of background interstitial pneumonia. …
• NAID 120005627354

• インジウムの健康影響 (特集 職業関連疾患 : 最新の動向と対策) -- (最近注目されている職業関連疾患)

• 中野 真規子,大前 和幸
• 日本臨床 72(2), 317-322, 2014-02
• NAID 40019951544

Related Links

• Pulmonary Interstitial Emphysema (PIE)

8 Jun 2011 ... Pulmonary interstitial emphysema (PIE) is a collection of gases outside of the normal air passages and inside the connective tissue of the peribronchovascular sheaths, interlobular septa, and visceral pleura.

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★リンクテーブル★

リンク元	「PIE」
関連記事	「interstitial」「emphysema」「pulmonary」

「PIE」

　　[★]

同

pulmonary infiltrates with eosinophilia

同

pulmonary interstitial emphysema

「interstitial」

　　[★]

• adj.

• 間質性の、間質内の、侵入型の、組織内の、介在の、介在性の、中間部の、間質の

関

intercalary、intermediate、internuncial、interstitial tissue、interstitium、intervene、intervening、interzonal、invasive、stroma、stromal、stromata

　

「emphysema」

　　[★]

• n.

• 気腫
• 肺気腫

• ORIGIN mid 17th cent. (sense 2) : via late Latin from Greek emphusēma, from emphusan ‘puff up.’

• puff upは'息を切らす'

　 　

「pulmonary」

　　[★]

• adj.

• 肺の、肺性の

関

lung、pneumo