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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/22 18:30:58」(JST)

Protionamide (or prothionamide) is a drug used in the treatment of tuberculosis.^[1]

It has also been tested for use in the treatment of leprosy.^[2]

References

^ Wang F, Langley R, Gulten G, et al. (January 2007). "Mechanism of thioamide drug action against tuberculosis and leprosy". J. Exp. Med. 204 (1): 73–8. doi:10.1084/jem.20062100. PMC 2118422. PMID 17227913.
^ Fajardo TT, Guinto RS, Cellona RV, Abalos RM, Dela Cruz EC, Gelber RH (March 2006). "A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy". Am. J. Trop. Med. Hyg. 74 (3): 457–61. PMID 16525107.

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A case of DRESS syndrome induced by the antituberculosis drugs, prothionamide, and para-aminosalycilic acid.

Kim JH, Jang SH, Kim DH, Park S, Kim DG, Jung KS.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.Ann Allergy Asthma Immunol.2013 Feb;110(2):118-9. doi: 10.1016/j.anai.2012.11.008. Epub 2012 Dec 5.
PMID 23352532

Ex vivo conversion of prodrug prothionamide to its metabolite prothionamide sulfoxide with different extraction techniques and their estimation in human plasma by LC-MS/MS.

Trivedi V, Upadhyay V, Shah G, Yadav M, Shrivastav PS, Sanyal M.SourceChemistry Department, Kadi Sarva Vishwavidyalaya, Sarva Vidyalaya Campus, Sector 15/23, Gandhinagar 382015, India.
Bioanalysis.Bioanalysis.2013 Jan;5(2):185-200. doi: 10.4155/bio.12.301.
BACKGROUND: The present work reports an ex vivo conversion study of prothionamide to its active metabolite prothionamide sulfoxide in human plasma during sample preparation by three conventional extraction techniques.RESULTS: The chromatography was done on a Hypersil™ Gold C18 (50 × 2.1 mm, 3.0 �
PMID 23330561

Identification and pathogenicity analysis of a novel non-tuberculous mycobacterium clinical isolate with nine-antibiotic resistance.

Zhang ZY, Sun ZQ, Wang ZL, Hu HR, Wen ZL, Song YZ, Zhao JW, Wang HH, Guo XK, Zhang SL.SourceDepartment of Medical Microbiology and Parasitology, Institutes of Medical Sciences, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.Clin Microbiol Infect.2013 Jan;19(1):91-6. doi: 10.1111/j.1469-0691.2012.03818.x. Epub 2012 Mar 22.
With mycobacteriosis increasing, the study of non-tuberculous mycobacteria is imperative for clinical therapy and management. Non-tuberculous mycobacteria are naturally resistant to most anti-tuberculosis drugs. Accordingly, it is important to decipher the biology of the novel non-tuberculous mycoba
PMID 22439981

Simple, rapid and sensitive determination of protionamide in human serum by high-performance liquid chromatography

BARTELS Helga,BARTELS Rainer
Journal of chromatography. B, Biomedical sciences and applications 707(1), 338-341, 1998-04-10
NAID 10024527317

リンク元	「プロチオナミド」「prothionamide」

Prothionamide
Systematic (IUPAC) name
	2-propylpyridine-4-carbothioamide
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	14222-60-7
ATC code	J04AD01
PubChem	CID: 666418
ChemSpider	579891
UNII	76YOO33643
Chemical data
Formula	C9H12N2S
Molecular mass	180.271 g/mol
	SMILES CCCc1cc(ccn1)C(=S)N ;
	InChI InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12) ; Key:VRDIULHPQTYCLN-UHFFFAOYSA-N ;
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