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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/24 15:21:50」(JST)

Protionamide (or prothionamide) is a drug used in the treatment of tuberculosis.^[1]

It has also been tested for use in the treatment of leprosy.^[2]

References

^ Wang F, Langley R, Gulten G et al. (January 2007). "Mechanism of thioamide drug action against tuberculosis and leprosy". J. Exp. Med. 204 (1): 73–8. doi:10.1084/jem.20062100. PMC 2118422. PMID 17227913.
^ Fajardo TT, Guinto RS, Cellona RV, Abalos RM, Dela Cruz EC, Gelber RH (March 2006). "A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy". Am. J. Trop. Med. Hyg. 74 (3): 457–61. PMID 16525107.

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Efficacy and tolerability of ethionamide versus prothionamide: a systematic review.

Scardigli A1, Caminero JA2, Sotgiu G3, Centis R4, D'Ambrosio L5, Migliori GB6.
The European respiratory journal.Eur Respir J.2016 Jun 10. pii: ERJ-00438-2016. doi: 10.1183/13993003.00438-2016. [Epub ahead of print]
PMID 27288034

Jung EK1, Chang JY1, Lee YP1, Chung MK1, Seo EK2, Koo HS3, Choi HJ1.
Infection & chemotherapy.Infect Chemother.2016 Mar;48(1):41-6. doi: 10.3947/ic.2016.48.1.41. Epub 2016 Mar 31.
We report a case of a 23-year-old female immigrant from China who was diagnosed with multidrug-resistant tuberculosis affecting her lung and brain, resistant to the standard first-line therapeutics and streptomycin. She was treated with prothionamide, moxifloxacin, cycloserine, and kanamycin. Howeve
PMID 27104015

Thee S1, Garcia-Prats AJ2, Donald PR2, Hesseling AC2, Schaaf HS2.
Tuberculosis (Edinburgh, Scotland).Tuberculosis (Edinb).2016 Mar;97:126-36. doi: 10.1016/j.tube.2015.09.007. Epub 2015 Oct 19.
Ethionamide (ETH) and prothionamide (PTH), both thioamides, have proven efficacy in clinical studies and form important components for multidrug-resistant tuberculosis treatment regimens and for treatment of tuberculous meningitis in adults and children. ETH and PTH are pro-drugs that, following enz
PMID 26586647

重藤えり子,村上功,横崎恭之
結核 76(4), 379-383, 2001-04-15
… She was treated with a regimen containing ethambutol (EB), prothionamide (TH) and enviomycin (EVM) but continued to be culture positive. …
NAID 10007072188

田村昌敏 [他],山田正雄,生垣浩,高沢直之
結核 54(2), 75-84, 1979
… Excretion of acid-fast bacilli in their sputa were observed after the change of the drugs.<BR>Following results were obtained.<BR>1) The combination of kanamycin plus prothionamide (or ethionamide) plus ethambutol was most effective to <I>Mycobacterium intracellulare</I> …
NAID 130001417500

Prothionamide
Systematic (IUPAC) name
	2-propylpyridine-4-carbothioamide
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	14222-60-7
ATC code	J04AD01
PubChem	CID: 666418
ChemSpider	579891
UNII	76YOO33643
Chemical data
Formula	C9H12N2S
Molecular mass	180.271 g/mol
	SMILES CCCc1cc(ccn1)C(=S)N ;
	InChI InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12) ; Key:VRDIULHPQTYCLN-UHFFFAOYSA-N ;
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