プロチオナミド
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- protionamide
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/24 15:21:50」(JST)
[Wiki en表示]
Prothionamide
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Systematic (IUPAC) name |
2-propylpyridine-4-carbothioamide
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Clinical data |
AHFS/Drugs.com |
International Drug Names |
Identifiers |
CAS Registry Number |
14222-60-7 Y |
ATC code |
J04AD01 |
PubChem |
CID: 666418 |
ChemSpider |
579891 N |
UNII |
76YOO33643 Y |
Chemical data |
Formula |
C9H12N2S |
Molecular mass |
180.271 g/mol |
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InChI
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InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12) N
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Key:VRDIULHPQTYCLN-UHFFFAOYSA-N N
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N (what is this?) (verify) |
Protionamide (or prothionamide) is a drug used in the treatment of tuberculosis.[1]
It has also been tested for use in the treatment of leprosy.[2]
See also
References
- ^ Wang F, Langley R, Gulten G et al. (January 2007). "Mechanism of thioamide drug action against tuberculosis and leprosy". J. Exp. Med. 204 (1): 73–8. doi:10.1084/jem.20062100. PMC 2118422. PMID 17227913.
- ^ Fajardo TT, Guinto RS, Cellona RV, Abalos RM, Dela Cruz EC, Gelber RH (March 2006). "A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy". Am. J. Trop. Med. Hyg. 74 (3): 457–61. PMID 16525107.
Antimycobacterials, including tuberculosis treatment and leprostatic agents (J04)
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Nucleic acid inhibitor |
Rifamycins/
RNA polymerase inhibitor |
- Rifampicin#
- Rifabutin
- Rifapentine
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Antifolates/DSI |
- Dapsone#
- Acedapsone
- Aldesulfone sodium
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ASA |
- 4-Aminosalicylic acid# (Calcium aminosalicylate
- Sodium aminosalicylate)
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Protein synthesis inhibitor |
Aminoglycosides |
- Amikacin#
- Capreomycin#
- Kanamycin#
- Streptomycin#
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Oxazolidone |
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Cell envelope antibiotic |
Peptidoglycan layer |
- Alanine analogue: Cycloserine#
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Arabinogalactan layer |
- Ethylenediamine/arabinosyltransferase inhibitor: Ethambutol#
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Mycolic acid layer |
- Hydrazides/mycolic acid synth. inhibition: Isoniazid#
- Thiocarbamides: Ethionamide#
- Prothionamide
- Thiocarlide
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Other/unknown |
- Phenazine (Clofazimine)#
- Pyrazine (Pyrazinamide#, Morinamide)
- Isoxazole (Terizidone)
- Bedaquiline
- Metronidazole (delamanid)
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Combinations |
- Rifampicin/isoniazid/pyrazinamide
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Index of bacterial disease
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Description |
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Disease |
- Gram-positive firmicutes
- Gram-positive actinobacteria
- Gram-negative proteobacteria
- Gram-negative non-proteobacteria
- Cholera
- Tuberculosis
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Treatment |
- Antibiotics
- cell wall
- nucleic acid
- mycobacteria
- protein synthesis
- other
- Antibodies
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UpToDate Contents
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English Journal
- Efficacy and tolerability of ethionamide versus prothionamide: a systematic review.
- Scardigli A1, Caminero JA2, Sotgiu G3, Centis R4, D'Ambrosio L5, Migliori GB6.
- The European respiratory journal.Eur Respir J.2016 Jun 10. pii: ERJ-00438-2016. doi: 10.1183/13993003.00438-2016. [Epub ahead of print]
- PMID 27288034
- A Case of Disseminated Multidrug-Resistant Tuberculosis involving the Brain.
- Jung EK1, Chang JY1, Lee YP1, Chung MK1, Seo EK2, Koo HS3, Choi HJ1.
- Infection & chemotherapy.Infect Chemother.2016 Mar;48(1):41-6. doi: 10.3947/ic.2016.48.1.41. Epub 2016 Mar 31.
- We report a case of a 23-year-old female immigrant from China who was diagnosed with multidrug-resistant tuberculosis affecting her lung and brain, resistant to the standard first-line therapeutics and streptomycin. She was treated with prothionamide, moxifloxacin, cycloserine, and kanamycin. Howeve
- PMID 27104015
- A review of the use of ethionamide and prothionamide in childhood tuberculosis.
- Thee S1, Garcia-Prats AJ2, Donald PR2, Hesseling AC2, Schaaf HS2.
- Tuberculosis (Edinburgh, Scotland).Tuberculosis (Edinb).2016 Mar;97:126-36. doi: 10.1016/j.tube.2015.09.007. Epub 2015 Oct 19.
- Ethionamide (ETH) and prothionamide (PTH), both thioamides, have proven efficacy in clinical studies and form important components for multidrug-resistant tuberculosis treatment regimens and for treatment of tuberculous meningitis in adults and children. ETH and PTH are pro-drugs that, following enz
- PMID 26586647
Japanese Journal
- リファンピシン耐性が消失し,治療17年目に菌陰性化に成功した薬剤耐性結核の1例
- 重藤 えり子,村上 功,横崎 恭之
- 結核 76(4), 379-383, 2001-04-15
- … She was treated with a regimen containing ethambutol (EB), prothionamide (TH) and enviomycin (EVM) but continued to be culture positive. …
- NAID 10007072188
- Mycobacteria intracellulare症に対する化学療法
- 田村 昌敏 [他],山田 正雄,生垣 浩,高沢 直之
- 結核 54(2), 75-84, 1979
- … Excretion of acid-fast bacilli in their sputa were observed after the change of the drugs.<BR>Following results were obtained.<BR>1) The combination of kanamycin plus prothionamide (or ethionamide) plus ethambutol was most effective to <I>Mycobacterium intracellulare</I> …
- NAID 130001417500
- Prothionamideによる肝障害の電子顕微鏡的観察
Related Links
- Buy Prothionamide (CAS 14222-60-7), an antibacterial, from Santa Cruz Biotechnology. Purity ≥98%, Molecular Formula C9H12N2S, Molecular Weight 180.27 ... 外観: Crystalline powder 物理的状態: Solid 溶解性: Soluble in ...
- 1314TH(Ethionamide)と1321TH(Prothionamide)の肝障害に関する臨床的研究:剤型を同一にした比較研究 CLINICAL STUDY ON HEPATIC DISTURBANCE DURING ETHIONAMIDE OR PROTHIONAMIDE TREATMENT:Comparative Study ...
Related Pictures
★リンクテーブル★
[★]
- 英
- prothionamide、protionamide
- ラ
- prothionamidum
- 関
- 抗結核薬、エチオナミド
[★]
プロチオナミド
- 関
- prothionamide