proteinuric

WordNet

the presence of excessive protein (chiefly albumin but also globulin) in the urine; usually a symptom of kidney disorder (同)proteinuria

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1. 成人の非糖尿病性慢性腎臓病患者に対する降圧療法と病状の進展 antihypertensive therapy and progression of nondiabetic chronic kidney disease in adults
2. 急性および慢性腎臓病における高血圧の概要 overview of hypertension in acute and chronic kidney disease
3. 微量アルブミン尿および心血管疾患 moderately increased albuminuria microalbuminuria and cardiovascular disease
4. 糸球体足細胞のバイオロジー biology of glomerular podocytes
5. C3糸球体症の移植後再発 recurrence of c3 glomerulopathies after transplantation

CD2-associated protein participates in podocyte apoptosis via PI3K/Akt signaling pathway.

Ren Q1, You Yu S2.
Journal of receptor and signal transduction research.J Recept Signal Transduct Res.2016 Jun;36(3):288-91. doi: 10.3109/10799893.2015.1101137. Epub 2015 Nov 20.
CD2-associated protein is one of the most important slit diaphragm proteins in maintaining podocyte integrity and reducing proteinuria. In the last 15 years, progressive researches have shown that CD2AP serves as an adaptor protein, plays essential roles in the podocyte cytoskeletal structure and si
PMID 26584949

Lin JS1, Susztak K2.
Current diabetes reports.Curr Diab Rep.2016 May;16(5):45. doi: 10.1007/s11892-016-0735-5.
Diabetes is increasing in prevalence and is the leading cause of end-stage renal disease in the United States. Diabetic kidney disease is considered a proteinuric glomerular disease. Although the glomerulus is composed of various cell types, research suggests that podocytes are critical to overall g
PMID 27053072

The β isoform of GSK3 mediates podocyte autonomous injury in proteinuric glomerulopathy.

Li C1,2, Ge Y2, Dworkin L2, Peng A1, Gong R2.
The Journal of pathology.J Pathol.2016 May;239(1):23-35. doi: 10.1002/path.4692. Epub 2016 Mar 16.
Converging evidence points to glycogen synthase kinase (GSK) 3 as a key player in the pathogenesis of podocytopathy and proteinuria. However, it remains unclear if GSK3 is involved in podocyte autonomous injury in glomerular disease. In normal kidneys, the β isoform of GSK3 was found to be the majo
PMID 26876299