protein precursor

• タンパク質前駆体

関

preprotein

WordNet

1. a substance from which another substance is formed (especially by a metabolic reaction)
2. a person who goes before or announces the coming of another (同)forerunner
3. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

PrepTutorEJDIC

1. (…の)前朕,前触れ《+『of』+『名』》
2. 蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/23 14:55:12」(JST)

wiki en

[Wiki en表示]

For other uses, see Precursor (disambiguation).

Propeptides
Identifiers
OPM superfamily	292
OPM protein	1wn8

A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by posttranslational modification. The name of the precursor for a protein is often prefixed by pro. Examples include proinsulin and proopiomelanocortin.

Protein precursors are often used by an organism when the subsequent protein is potentially harmful, but needs to be available on short notice and/or in large quantities. Enzyme precursors are called zymogens or proenzymes. Examples are enzymes of the digestive tract in humans.

Some protein precursors are secreted from the cell. Many of these are synthesized with an N-terminal signal peptide that targets them for secretion. Like other proteins that contain a signal peptide, their name is prefixed by pre. They are thus called pre-pro-proteins or pre-pro-peptides. The signal peptide is cleaved off in the endoplasmic reticulum. An example is preproinsulin.

References

UpToDate Contents

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• 1. アミロイド疾患の遺伝的要因 genetic factors in the amyloid diseases
• 2. アルツハイマー病の遺伝学 genetics of alzheimer disease
• 3. プロテインS欠乏症：臨床症状および診断 protein s deficiency clinical manifestations and diagnosis
• 4. 幼児の食物蛋白誘発性直腸炎/大腸炎および腸疾患 food protein induced proctitis colitis and enteropathy of infancy
• 5. サーファクタント機能障害の遺伝性疾患 genetic disorders of surfactant dysfunction

English Journal

• Agmatinase, an inactivator of the putative endogenous antidepressant agmatine, is strongly upregulated in hippocampal interneurons of subjects with mood disorders.

• Bernstein HG, Stich C, Jager K, Dobrowolny H, Wick M, Steiner J, Veh R, Bogerts B, Laube G.SourceDepartment of Psychiatry, University of Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany.
• Neuropharmacology.Neuropharmacology.2012 Jan;62(1):237-46. Epub 2011 Jul 22.
• The diamine agmatine may serve as a precursor in polyamine synthesis. In addition, agmatine may also act as a neurotransmitter, binding to imidazoline receptors. Behaviorally, agmatine exerts antidepressant-like effects. The enzyme agmatinase degrades agmatine. The gene coding for human agmatinase i
• PMID 21803059

• Subtleties of biomineralisation revealed by manipulation of the eggshell membrane.

• Li N, Niu LN, Qi YP, Yiu CK, Ryou H, Arola DD, Chen JH, Pashley DH, Tay FR.SourceCollege of Osteopedics & Traumatology, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
• Biomaterials.Biomaterials.2011 Dec;32(34):8743-52. Epub 2011 Aug 23.
• Biocalcification of collagen matrices with calcium phosphate and biosilicification of diatom frustules with amorphous silica are two discrete processes that have intrigued biologists and materials scientists for decades. Recent advancements in the understanding of the mechanisms involved in these tw
• PMID 21864897

Japanese Journal

• Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease

• Yahata Naoki,Asai Masashi,Kitaoka Shiho,Takahashi Kazutoshi,Asaka Isao,Hioki Hiroyuki,Kaneko Takeshi,Maruyama Kei,Saido Takaomi C.,Nakahata Tatsutoshi,Asada Takashi,Yamanaka Shinya,Iwata Nobuhisa,Inoue Haruhisa
• PLoS ONE 6(9), e25788, 2011-09-30
• … The AD brain is characterized by deposition of amyloid β peptide (Aβ), which is produced from amyloid precursor protein by β- and γ-secretase (presenilin complex)-mediated sequential cleavage. … The iPS cell-derived neuronal cells also expressed amyloid precursor protein, β-secretase, and γ-secretase components, and were capable of secreting Aβ into the conditioned media. …
• NAID 120003386527

• Synthesis and evaluation of a radioiodinated trisaccharide derivative as a synthetic substrate for a sensitive N-acetylglucosaminyltransferase V radioassay.

• Mukai Takahiro,Hagimori Masayori,Arimitsu Kenji,Katoh Takahiro,Ukon Misa,Kajimoto Tetsuya,Kimura Hiroyuki,Magata Yasuhiro,Miyoshi Eiji,Taniguchi Naoyuki,Node Manabu,Saji Hideo
• Bioorganic & medicinal chemistry 19(14), 4312-4321, 2011-07-15
• … The tributyltin derivative, 2-[4-(n-tributylstannyl)phenyl]ethyl 6-O-[2-O-(3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-β-d-glucopyranosyl)-3,4,6-tri-O-acetyl-α-d-mannopyranosyl]-2,3,4-tri-O-acetyl-β-d-glucopyranoside (21), was synthesized as a precursor for the preparation of [(125)I]1. … μg protein. …
• NAID 120003255723

Related Links

• Protein precursor - Wikipedia, the free encyclopedia

A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an active form by posttranslational modification. The name of the precursor for a protein is often prefixed by pro. Examples ...

Related Pictures

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★リンクテーブル★

リンク元	「preprotein」「タンパク質前駆体」
拡張検索	「amyloid beta-protein precursor」
関連記事	「precursor」

「preprotein」

　　[★]

• タンパク質前駆体、前タンパク質

関

protein precursor

「タンパク質前駆体」

　　[★]

英

protein precursor、preprotein

関

前タンパク質

「amyloid beta-protein precursor」

　　[★]

• アミロイドβタンパク質前駆体

関

amyloid beta precursor protein

「precursor」

　　[★]

• n.

• 前駆物質、前駆体、先駆物質、前駆型の

関

progenitor