p53タンパク質
- 関
- p53 protein
WordNet
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
PrepTutorEJDIC
- 蛋白(たんばく)質
UpToDate Contents
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English Journal
- Coumestrol induces senescence through protein kinase CKII inhibition-mediated reactive oxygen species production in human breast cancer and colon cancer cells.
- Lee YH, Yuk HJ, Park KH, Bae YS.SourceSchool of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Republic of Korea.
- Food chemistry.Food Chem.2013 Nov 1;141(1):381-8. doi: 10.1016/j.foodchem.2013.03.053. Epub 2013 Mar 23.
- An inhibitor of the protein kinase CKII (CKII) was purified from leaves of Glycine max (L.) Merrill and was identified as coumestrol by structural analysis. Coumestrol inhibited the phosphotransferase activity of CKII toward β-casein, with an IC50 of about 5μM. It acted as a competitive inhibitor
- PMID 23768371
- Epigallocatechin gallate inhibits growth and epithelial-to-mesenchymal transition in human thyroid carcinoma cell lines.
- De Amicis F, Perri A, Vizza D, Russo A, Panno ML, Bonofiglio D, Giordano C, Mauro L, Aquila S, Tramontano D, Andò S.SourceCentro Sanitario, University of Calabria, Italy; Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, Italy.
- Journal of cellular physiology.J Cell Physiol.2013 Oct;228(10):2054-62. doi: 10.1002/jcp.24372.
- Well-differentiated papillary and follicular thyroid carcinoma are the most frequent types of thyroid cancer and the prognosis is generally favorable however, a number of patients develops recurrences. Epigallocatechin-3-gallate (EGCG), a major catechin in green tea, was shown to possess remarkable
- PMID 23553645
- Sensitive chemiluminescence detection of wild-type p53 protein captured by surface-confined consensus DNA duplexes.
- Chen X, He C, Zhang Z, Wang J.SourceCollege of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan, People's Republic of China; Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, Hunan, People's Republic of China.
- Biosensors & bioelectronics.Biosens Bioelectron.2013 Sep 15;47:335-9. doi: 10.1016/j.bios.2013.03.059. Epub 2013 Apr 1.
- A novel chemiluminescence (CL) biosensor for sensitive detection of wild-type p53 protein has been proposed. The wild-type p53 protein in solution was captured by highly specific consensus double-stranded (ds) oligonucleotides (ODNs) preimmobilized onto a gold plate. The cysteine residues on the ext
- PMID 23603130
Japanese Journal
- Gender differences in clinicopathological features and prognosis of squamous cell carcinoma of the esophagus
- Esophagus : official journal of the Japan Esophageal Society 14(2), 122-130, 2017-04
- NAID 40021166179
- Decreased RNA-binding motif 5 expression is associated with tumor progression in gastric cancer
- Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1
★リンクテーブル★
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- 同
- (遺伝子)p53 gene p53遺伝子
- (蛋白質)p53 protein p53蛋白質
p53遺伝子
- MDM2はp53と結合して安定化し、ユビキチン化を介してP53の分解に導く
- 活性化ATM(DNA損傷などが引き金となる)はp53をリン酸化する
- リン酸化されたp53は次の経路を活性化する
- →Bax→アポトーシス
- →p21WAP1/CII1→細胞周期停止
- →GADD45
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p53(蛋白質)=
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- 10の-12乗
- 関
- pico