English Journal

Trypanosoma cruzi dihydrolipoamide dehydrogenase as target for phenothiazine cationic radicals. Effect of antioxidants.

Gutiérrez-Correa J.SourceInstituto de Medicina Tropical Daniel A. Carrión, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. josegutierrezc@speedy.com.pe
Current drug targets.Curr Drug Targets.2006 Sep;7(9):1155-79.
Myeloperoxidase (MPO), myoglobin (Mb) and horseradish peroxidase (HRP), catalyzed the generation of radical-cations by one-electron oxidation of phenothiazines (PTZ). The transient formation of these radicals (PTZ+.) was confirmed by ESR and optical spectroscopy. These species are reactive towards T
PMID 17017892

Ichikawa M, Urayama M, Matsumoto G.SourceElectrotechnical Laboratory, Molecular and Cellular Neuroscience Section, Ibaraki, Japan.
The Journal of membrane biology.J Membr Biol.1991 Mar;120(3):211-22.
The effects of calmodulin (CaM) antagonists (W-7, W-5, trifluoperazine, chlorpromazine, quinacrine, diazepam, propericyazine and carmidazolium) on the sodium and potassium channels were studied on the intracellularly perfused and voltage-clamped giant axon of the squid. It was found that the drugs a
PMID 1675687