プラモキシン
WordNet
- a complex consisting of an organic base in association with hydrogen chloride
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/22 03:34:26」(JST)
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Pramocaine
|
Systematic (IUPAC) name |
4-[3-(4-butoxyphenoxy)propyl]morpholine
|
Clinical data |
AHFS/Drugs.com |
International Drug Names |
MedlinePlus |
a682429 |
Legal status |
- CA: OTC
- UK: POM (Prescription only)
- OTC/POM
|
Routes of
administration |
Topical, rectal, Vaginal |
Identifiers |
CAS Number |
140-65-8 N 637-58-1 |
ATC code |
D04AB07 C05AD07 |
PubChem |
CID: 4886 |
ChemSpider |
4717 Y |
UNII |
068X84E056 Y |
ChEBI |
CHEBI:8357 Y |
ChEMBL |
CHEMBL1198 Y |
Chemical data |
Formula |
C17H27NO3 |
Molecular mass |
293.401 g/mol |
SMILES
-
O(c2ccc(OCCCN1CCOCC1)cc2)CCCC
|
InChI
-
InChI=1S/C17H27NO3/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18/h5-8H,2-4,9-15H2,1H3 Y
-
Key:DQKXQSGTHWVTAD-UHFFFAOYSA-N Y
|
NY (what is this?) (verify) |
Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953[1] and used as an antipruritic. Chemically, it is p-n butoxyphenyl gammamorpholinopropyl ether hydrochloride. During research and development, pramoxine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent.[1] Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in man.[1] Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.
The popular itch creams Gold Bond and some forms of Calamine Lotion use pramocaine hydrochloride to numb sensitive skin, as does the pain relief variant of Neosporin and some formulations of Sarna. The hydrochloride salt form of pramocaine is water-soluble.
Usage
Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches.[2] Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.
See also
Notes
- ^ a b c Schmidt JL, Blockus LE, Richards RK. The Pharmacology of Pramoxine Hydrochloride: A New Topical Local Anesthetic. Curr Res Anesth Analg. 1953 Nov-Dec;32(6:1):418-25.
- ^ "Pramoxine". MedlinePlus Drug Information. National Library of Medicine. September 25, 2013. Retrieved October 9, 2013.
Vasoprotectives (C05)
|
|
Antihemorrhoidals for topical use |
corticosteroids |
- Hydrocortisone
- Prednisolone
- Betamethasone
- Fluorometholone
- Fluocortolone
- Dexamethasone
- Fluocinolone acetonide
- Fluocinonide
|
|
local anesthetics |
- Lidocaine
- Tetracaine
- Benzocaine
- Dibucaine
- Procaine
- Oxetacaine
- Pramocaine
|
|
other |
|
|
|
Antivaricose therapy |
heparins or heparinoids for topical use |
- Organo-heparinoid
- Sodium apolate
- Heparin
- Pentosan polysulfate
|
|
sclerosing agents for local injection |
- Monoethanolamine oleate
- Polidocanol
- Inverted sugar syrup
- Sodium tetradecyl sulfate
- Phenol
|
|
other |
|
|
|
Capillary stabilising agents |
bioflavonoids |
- Rutoside
- Monoxerutin
- Diosmin
- Troxerutin
- Hidrosmin
|
|
other |
|
|
|
Index of the circulatory system
|
|
Description |
- Anatomy
- Arteries
- head and neck
- arms
- chest
- abdomen
- legs
- Veins
- head and neck
- arms
- chest
- abdomen and pelvis
- legs
- Development
- Cells
- Physiology
|
|
Disease |
- Congenital
- Neoplasms and cancer
- Lymphatic vessels
- Injury
- Vasculitis
- Other
- Symptoms and signs
|
|
Treatment |
- Procedures
- Drugs
- beta blockers
- channel blockers
- diuretics
- nonsympatholytic vasodilatory antihypertensives
- peripheral vasodilators
- renin–angiotensin system
- sympatholytic antihypertensives
- vasoprotectives
|
|
|
Antipruritics (D04)
|
|
Antihistamines for topical use |
- Thonzylamine
- Mepyramine
- Thenalidine
- Tripelennamine
- Chloropyramine
- Promethazine
- Tolpropamine
- Dimetindene
- Clemastine
- Bamipine
- Isothipendyl
- Diphenhydramine
- Chlorphenoxamine
|
|
Anesthetics for topical use |
- Lidocaine
- Dibucaine
- Oxybuprocaine
- Benzocaine
- Quinisocaine
- Tetracaine
- Pramocaine
|
|
Others |
- Corticosteroids (e.g., hydrocortisone)
- Counterirritants (e.g., mint oil, menthol, camphor)
- Nalfurafine
|
|
Index of skin
|
|
Description |
- Anatomy
- Physiology
- Development
|
|
Disease |
- Infections
- Vesiculobullous
- Dermatitis and eczema
- Papulosquamous
- Urticaria and erythema
- Radiation-related
- Pigmentation
- Mucinoses
- Keratosis, ulcer, atrophy, and necrobiosis
- Vasculitis
- Fat
- Neutrophilic and eosinophilic
- Congenital
- Neoplasms and cancer
- nevi and melanomas
- epidermis
- dermis
- Symptoms and signs
- Terminology
|
|
Treatment |
- Procedures
- Drugs
- antibiotics
- disinfectants
- emollients and protectives
- itch
- psoriasis
- other
- Wound and ulcer
|
|
|
UpToDate Contents
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English Journal
- Local cooling for relieving pain from perineal trauma sustained during childbirth.
- East CE, Begg L, Henshall NE, Marchant PR, Wallace K.SourceDepartment ofObstetrics and Gynaecology, University ofMelbourne, Pregnancy Research Centre,Department of PerinatalMedicine,RoyalWomen’sHospital, Parkville, Australia. eastc@unimelb.edu.au.
- Cochrane database of systematic reviews (Online).Cochrane Database Syst Rev.2012 May 16;5:CD006304. doi: 10.1002/14651858.CD006304.pub3.
- BACKGROUND: Perineal trauma is common during childbirth and may be painful. Contemporary maternity practice includes offering women numerous forms of pain relief, including the local application of cooling treatments.OBJECTIVES: To evaluate the effectiveness and side effects of localised cooling tre
- PMID 22592710
- Efficacy and onset of action of hydrocortisone acetate 2.5% and pramoxine hydrochloride 1% lotion for the management of pruritus: results of a pilot study.
- Kircik LH.SourceClinical Associate Professor of Dermatology, Mount Sinai Medical Center and Indiana University School of Medicine; Director, Physician Skin Care, PLLC, and DermResearch, PLLC, Louisville, Kentucky.
- The Journal of clinical and aesthetic dermatology.J Clin Aesthet Dermatol.2011 Feb;4(2):48-50.
- Itch is the most common symptom among patients presenting to the dermatology clinic. Scratching can cause mechanical trauma to the skin, further damaging the epidermal barrier and its function. This damage can facilitate the introduction of microbes that complicate the presenting disease and its man
- PMID 21386957
Related Links
- Pramoxine Hydrochloride reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). ... Cautions for Pramoxine Hydrochloride Contraindications Known hypersensitivity to ...
- Pramoxine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: redness, irritation, swelling, burning, stinging, or pain at affected area dryness at affected area Some side effects can be ...
★リンクテーブル★
[★]
- 英
- pramoxine
- 化
- 塩酸プラモキシン pramoxine hydrochloride
- 関
- プラモカイン
[★]
- 英
- pramoxine hydrochloride
- 関
- プラモカイン、プラモキシン
[★]
プラモカイン
- 関
- pramoxine、pramoxine hydrochloride
[★]
プラモキシン
- 関
- pramocaine、pramoxine hydrochloride
[★]
塩酸塩、ハイドロクロライド