プラモキシン
- 関
- pramocaine、pramoxine hydrochloride
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/05/09 11:17:11」(JST)
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Pramocaine
|
Systematic (IUPAC) name |
4-[3-(4-butoxyphenoxy)propyl]morpholine |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
MedlinePlus |
a682429 |
Legal status |
OTC (CA) POM (UK) OTC/POM |
Routes |
Topical, rectal |
Identifiers |
CAS number |
140-65-8 N 637-58-1 |
ATC code |
D04AB07 C05AD07 |
PubChem |
CID 4886 |
ChemSpider |
4717 Y |
UNII |
068X84E056 Y |
ChEBI |
CHEBI:8357 Y |
ChEMBL |
CHEMBL1198 Y |
Chemical data |
Formula |
C17H27NO3 |
Mol. mass |
293.401 g/mol |
SMILES
- O(c2ccc(OCCCN1CCOCC1)cc2)CCCC
|
InChI
-
InChI=1S/C17H27NO3/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18/h5-8H,2-4,9-15H2,1H3 Y
Key:DQKXQSGTHWVTAD-UHFFFAOYSA-N Y
|
N (what is this?) (verify) |
Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953[1] and used as an antipruritic. Chemically, it is p-n butoxyphenyl gammamorpholinopropyl ether hydrochloride. During research and development, pramoxine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent.[1] Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in man.[1] Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.
The popular itch creams Gold Bond and Calamine Lotion use pramocaine hydrochloride to numb sensitive skin, as does the pain relief variant of Neosporin and some formulations of Sarna. The hydrochloride salt form of pramocaine is water-soluble.
Usage
Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches.[2] Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.
Notes
- ^ a b c Schmidt JL, Blockus LE, Richards RK. The Pharmacology of Pramoxine Hydrochloride: A New Topical Local Anesthetic. Curr Res Anesth Analg. 1953 Nov-Dec;32(6:1):418-25.
- ^ "Pramoxine". MedlinePlus Drug Information. National Library of Medicine. September 25, 2013. Retrieved October 9, 2013.
See also
Vasoprotectives (C05)
|
|
Antihemorrhoidals for topical use |
corticosteroids |
- Hydrocortisone
- Prednisolone
- Betamethasone
- Fluorometholone
- Fluocortolone
- Dexamethasone
- Fluocinolone acetonide
- Fluocinonide
|
|
local anesthetics |
- Lidocaine
- Tetracaine
- Benzocaine
- Dibucaine
- Procaine
- Oxetacaine
- Pramocaine
|
|
other |
|
|
|
Antivaricose therapy |
heparins or heparinoids for topical use |
- Organo-heparinoid
- Sodium apolate
- Heparin
- Pentosan polysulfate
|
|
sclerosing agents for local injection |
- Monoethanolamine oleate
- Polidocanol
- Inverted sugar syrup
- Sodium tetradecyl sulfate
- Phenol
|
|
other |
|
|
|
Capillary stabilising agents |
bioflavonoids |
- Rutoside
- Monoxerutin
- Diosmin
- Troxerutin
- Hidrosmin
|
|
other |
|
|
|
|
anat (a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot
|
noco/syva/cong/lyvd/tumr, sysi/epon, injr
|
proc, drug (C2s+n/3/4/5/7/8/9)
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|
|
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Antipruritics (D04)
|
|
Antihistamines for topical use |
- Thonzylamine
- Mepyramine
- Thenalidine
- Tripelennamine
- Chloropyramine
- Promethazine
- Tolpropamine
- Dimetindene
- Clemastine
- Bamipine
- Isothipendyl
- Diphenhydramine
- Chlorphenoxamine
|
|
Anesthetics for topical use |
- Lidocaine
- Dibucaine
- Oxybuprocaine
- Benzocaine
- Quinisocaine
- Tetracaine
- Pramocaine
|
|
|
|
noco (i/b/d/q/u/r/p/m/k/v/f)/cong/tumr (n/e/d), sysi/epon
|
proc, drug (D2/3/4/5/8/11)
|
|
|
|
UpToDate Contents
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English Journal
- Anaphylaxis due to topical pramoxine.
- Kim SJ1, Goldberg BJ2.
- Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.Ann Allergy Asthma Immunol.2015 Jan;114(1):72-3. doi: 10.1016/j.anai.2014.10.011. Epub 2014 Nov 14.
- PMID 25457867
- Contact allergy to pramoxine (pramocaine): the importance of testing to personal products.
- Hylwa SA1, Warshaw E.
- Dermatitis : contact, atopic, occupational, drug.Dermatitis.2014 May-Jun;25(3):147-8. doi: 10.1097/DER.0000000000000038.
- We offer a case of contact allergy to pramoxine, a rare sensitizer.
- PMID 24819289
- [A case of prostate cancer presenting as extensive abdominal metastasis].
- Shirono Y1, Hanyu S, Ikarashi T.
- Hinyokika kiyo. Acta urologica Japonica.Hinyokika Kiyo.2013 Jan;59(1):51-5.
- A 73-year-old man was admitted to our hospital with a chief complaint of hematemesis. Two years before admission, adenocarcinoma of unknown origin was diagnosed. Since then, the patient had been taking TS-1 (pramoxine hydrochloride) medication, which caused gastroduodenal mucosal damage. A large abd
- PMID 23412126
Related Links
- Pramoxine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: redness, irritation, swelling, burning, stinging, or pain at affected area dryness at affected area Some side ...
- Physician reviewed pramoxine topical patient information - includes pramoxine topical description, dosage and directions. ... How should I use pramoxine topical? Use exactly as directed on the label, or as prescribed by your doctor.
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★リンクテーブル★
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- 英
- pramoxine
- 化
- 塩酸プラモキシン pramoxine hydrochloride
- 関
- プラモカイン
[★]
プラモカイン
- 関
- pramoxine、pramoxine hydrochloride