potentiation

• 増強、相乗

関

augment、augmentation、enhance、enhancement、intensify、potentiate、synergism

　

WordNet

1. (medicine) the synergistic effect of two drugs given simultaneously
2. make the chemically affected part of (a negative) denser or more opaque in order produce a stronger contrast between light and dark
3. make more intense, stronger, or more marked; "The efforts were intensified", "Her rudeness intensified his dislike for her"; "Pot smokers claim it heightens their awareness"; "This event only deepened my convictions" (同)compound, heighten, deepen
4. become more intense; "The debate intensified"; "His dislike for raw fish only deepened in Japan" (同)deepen
5. increase; "This will enhance your enjoyment"; "heighten the tension" (同)heighten, raise
6. make better or more attractive; "This sauce will enhance the flavor of the meat"
7. enlarge or increase; "The recent speech of the president augmented tensions in the Near East"
8. grow or intensify; "The pressure augmented"
9. the act of augmenting
10. the amount by which something increases
11. the statement of a theme in notes of greater duration (usually twice the length of the original)
12. an improvement that makes something more agreeable (同)sweetening

PrepTutorEJDIC

1. …‘を'強める,強烈にする / 強くなる,激しくなる
2. …‘の'程度(仮値など)を高める
3. …'を'増す,増大(増加)させる / 〈物・事が〉増す,増大(増加)する
4. 増大,増加 / 増加した物,付加物
5. 高揚,増進

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/27 20:37:50」(JST)

wiki en

[Wiki en表示]

In clinical terms, a potentiator is a reagent that enhances sensitization of an antigen. Potentiators are used in the clinical laboratory for performing blood banking procedures that require enhancement of Agglutination (biology) in order to detect the presence of antibodies or antigens in a patient's blood sample. Examples of potentiators include albumin, LISS (low ionic-strength saline) and PEG (polyethylene glycol). Potentiators are also known as enhancement reagents.

Albumin acts as a potentiator by reducing the zeta potential around the suspended red blood cells, thus dispersing the repulsive negative charges and enhancing agglutination. Low ionic strength saline is a potentiator that acts by not only reducing the zeta potential, but also by increasing the amount of antibody taken up by the red blood cell during sensitization. LISS is a solution of glycine and albumin. Polyethylene glycol in a LISS solution removes water from the system and thus concentrates the antibodies present. PEG can cause non-specific aggregation of cells, thus eliminating the necessity for centrifugation after 37 °C incubation. PEG is not appropriate for use in samples from patients with increased plasma protein, such as patients with multiple myeloma. False-positive results may occur more frequently with the use of polyethylene glycol due to its strong agglutination capabilities.

Pharmacology

In clinical pharmacology, a potentiator is a drug, herb, or chemical that intensifies the effects of a given drug, such as hydroxyzine used to get more pain relief and anxiolysis out of an equal dose of an opioid medication. The potentiation can take place at any part of the liberation, absorption, distribution, metabolism and elimination of the drug.

References

UpToDate Contents

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• 1. 心雑音および心音の鑑別診断における生理学的および薬理学的手法 physiologic and pharmacologic maneuvers in the differential diagnosis of heart murmurs and sounds
• 2. 冬眠心筋の評価 evaluation of hibernating myocardium
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• 4. 閉塞性肥大型心筋症の種類および病態生理 types and pathophysiology of obstructive hypertrophic cardiomyopathy
• 5. 心臓カテーテル検査で測定した弁膜疾患の血行動態 hemodynamics of valvular disorders as measured by cardiac catheterization

English Journal

• Androgen Receptor Coactivators in Regulation of Growth and Differentiation in Prostate Cancer.

• Culig Z1.
• Journal of cellular physiology.J Cell Physiol.2016 Feb;231(2):270-4. doi: 10.1002/jcp.25099.
• Androgen receptor (AR) is a key factor in regulation of growth and differentiation in normal and malignant prostate. Endocrine therapies for prostate cancer include inhibition of androgen production either by analogs of luteinizing hormone releasing hormone or abiraterone acetate and/or use of anti-
• PMID 26201947

• Lack of support for bexarotene as a treatment for Alzheimer's disease.

• O'Hare E1, Jeggo R2, Kim EM3, Barbour B4, Walczak JS5, Palmer P6, Lyons T7, Page D8, Hanna D9, Meara JR10, Spanswick D11, Guo JP12, McGeer EG12, McGeer PL13, Hobson P14.
• Neuropharmacology.Neuropharmacology.2016 Jan;100:124-30. doi: 10.1016/j.neuropharm.2015.04.020. Epub 2015 May 27.
• Bexarotene has been reported to reduce brain amyloid-β (Aβ) levels and to improve cognitive function in transgenic mouse models of Alzheimer's disease (AD). Four groups failed to fully replicate the primary results but the original authors claimed overall support for the general conclusions. Becau
• PMID 26025659

• Subchronic phencyclidine treatment in adult mice increases GABAergic transmission and LTP threshold in the hippocampus.

• Nomura T1, Oyamada Y2, Fernandes HB1, Remmers CL1, Xu J1, Meltzer HY3, Contractor A4.
• Neuropharmacology.Neuropharmacology.2016 Jan;100:90-7. doi: 10.1016/j.neuropharm.2015.04.012. Epub 2015 Apr 30.
• Repeated administration of non-competitive N-methyl-d-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP) to rodents causes long-lasting deficits in cognition and memory, and has effects on behaviors that have been suggested to be models of the cognitive impairment associated with schi
• PMID 25937215

Japanese Journal

• 男女の競技パフォーマンスにおける活動後増強効果 : 簡潔なレビュー

• DeRenne Coop
• Strength & conditioning journal : 日本ストレングス&コンディショニング協会機関誌 20(10), 38-43, 2013-12
• NAID 40019887311

• Synaptic Modulation via Basolateral Amygdala on the Rat Hippocampus-Medial Prefrontal Cortex Pathway in Fear Extinction

• Inoue Sumitaka,Kamiyama Hidekazu,Matsumoto Machiko [他]
• Journal of pharmacological sciences 123(3), 267-278, 2013-11
• NAID 40019885369

• Long-term Potentiation of Inhibitory Synaptic Transmission onto Cerebellar Purkinje Neurons Contributes to Adaptation of Vestibulo-Ocular Reflex.

• Tanaka Shinsuke,Kawaguchi Shin-Ya,Shioi Go,Hirano Tomoo
• The Journal of neuroscience : the official journal of the Society for Neuroscience 33(43), 17209-17220, 2013-10-23
• … Here, we have investigated the roles of long-lasting enhancement of transmission at GABAergic synapses on a PN that is known as rebound potentiation (RP). …
• NAID 120005342657

Related Links

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Potentiation Electromagnetic Repatterning. The first DNA activation in the Regenetics Method, Potentiation “resets” the human bioenergy blueprint, facilitating release of toxins and traumas and establishing a higher harmonic ...

• potentiation - definition of potentiation by the Free Online ...

... potentiation antonyms. Information about potentiation in the free online English dictionary and encyclopedia. Printer Friendly Dictionary, Encyclopedia and Thesaurus - The Free Dictionary 6,198,582,000 visitors served. forum ...

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★リンクテーブル★

リンク元	「enhance」「augment」「enhancement」「intensify」「augmentation」
拡張検索	「posttetanic potentiation」

「enhance」

　　[★]

• v.

• 増強する、亢進する、強化する、強める

関

augment、augmentation、consolidate、consolidation、enhancement、facilitate、facilitation、fortification、fortify、intensification、intensify、potentiate、potentiation、reinforce、reinforcement、sharpen、strengthen

　 　 　

「augment」

　　[★]

• vi.

• 増える、増加する、増大する

• vt.

• 増させる、増加させる、増大させる

• Don't confuse 'augment' and 'argument'.

関

augmentation、enhance、enhancement、enlarge、escalate、escalation、expansion、increase、increment、intensify、potentiate、potentiation

　 　 　

「enhancement」

　　[★]

• n.

• 増強、亢進、強化

関

augment、augmentation、consolidate、consolidation、enhance、facilitate、facilitation、fortification、fortify、intensification、intensify、potentiate、potentiation、reinforce、reinforcement、sharpen、strengthen

　 　

「intensify」

　　[★]

• v.

• 強化する、増強する、増感させる

関

augment、augmentation、consolidate、consolidation、enhance、enhancement、fortification、fortify、intensification、potentiate、potentiation、reinforce、reinforcement、sharpen、strengthen

　 　 　 　

「augmentation」

　　[★]

• n.

• 増大、増強

関

augment、enhance、enhancement、enlarge、escalate、escalation、expansion、increase、increment、intensify、potentiate、potentiation

　 　 　 　

「posttetanic potentiation」

　　[★]

• テタヌス後増強、後テタヌス性増強、反復刺激後増強、PTP