polynucleotide ligase

ポリヌクレオチドリガーゼ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/07/28 04:42:34」(JST)

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DNA ligase (NAD+)
Identifiers
EC number	6.5.1.2
CAS number	37259-52-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

DNA ligase (NAD+) (EC 6.5.1.2, polydeoxyribonucleotide synthase (NAD⁺), polynucleotide ligase (NAD⁺), DNA repair enzyme, DNA joinase, polynucleotide synthetase (nicotinamide adenine dinucleotide), deoxyribonucleic-joining enzyme, deoxyribonucleic ligase, deoxyribonucleic repair enzyme, deoxyribonucleic joinase, DNA ligase, deoxyribonucleate ligase, polynucleotide ligase, deoxyribonucleic acid ligase, polynucleotide synthetase, deoxyribonucleic acid joinase, DNA-joining enzyme, polynucleotide ligase (nicotinamide adenine dinucleotide)) is an enzyme with systematic name poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming). This enzyme catalyses the following chemical reaction

NAD⁺ + (deoxyribonucleotide)_n + (deoxyribonucleotide)_m $\rightleftharpoons$ AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)_n+m

Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA.

See also

• DNA ligase

External links

• DNA+ligase+(NAD+) at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

• Dumbbell DNA-templated CuNPs as a nano-fluorescent probe for detection of enzymes involved in ligase-mediated DNA repair.

• Qing T1, He X2, He D1, Ye X1, Shangguan J1, Liu J1, Yuan B1, Wang K3.
• Biosensors & bioelectronics.Biosens Bioelectron.2017 Aug 15;94:456-463. doi: 10.1016/j.bios.2017.03.035. Epub 2017 Mar 21.
• PMID 28340465

• Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex.

• Aceytuno RD1, Piett CG2, Havali-Shahriari Z1, Edwards RA1, Rey M2, Ye R2, Javed F1, Fang S2, Mani R3, Weinfeld M3, Hammel M4, Tainer JA4,5, Schriemer DC2, Lees-Miller SP2, Glover JNM1.
• Nucleic acids research.Nucleic Acids Res.2017 Apr 27. doi: 10.1093/nar/gkx275. [Epub ahead of print]
• PMID 28453785

• High-throughput sequencing reveals circular substrates for an archaeal RNA ligase.

• Becker HF1,2, Héliou A1,3, Djaout K1, Lestini R1, Regnier M3, Myllykallio H1.
• RNA biology.RNA Biol.2017 Mar 9:1-11. doi: 10.1080/15476286.2017.1302640. [Epub ahead of print]
• PMID 28277897

Japanese Journal

• Comparison of the molecular influences of NO-induced lesions in DNA strands on the reactivity of polynucleotide kinases, DNA ligases and DNA polymerases

• The journal of biochemistry 147(5), 697-703, 2010-05-01
• NAID 10027875826

• 眼球運動失行と低アルブミン血症を伴う早発型失調症の原因タンパク質aprataxin(APTX)の機能解析

• 新潟医学会雑誌 118(11), 632-639, 2004-11-10
• NAID 110004717178

• Scanning Mutagenesis Using T4 DNA Ligase and Short Degenerate DNA Oligonucleotides Containing Tri-nucleotide Mismatches.

• The Journal of Biochemistry 132(1), 143-147, 2002
• NAID 130006869534

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★リンクテーブル★

リンク元	「DNAリガーゼ」
関連記事	「ligase」

「DNAリガーゼ」

　　[★]

英

DNA ligase

同

DNA連結酵素 DNA joinase、ポリヌクレオチドリガーゼ polynucleotide ligase、ポリデオキシリボヌクレオチドシンターゼ polydeoxyribonucleotide synthase

「ligase」

　　[★]

リガーゼ、連結酵素

関

synthetase