・リドカノール

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/17 15:12:34」(JST)

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Polidocanol is a local anaesthetic and antipruritic component of ointments and bath additives. It relieves itching caused by eczema and dry skin.^[1]

The substance is also used as a sclerosant, an irritant injected to treat varicose veins, under the trade names Asclera, Aethoxysklerol^[2] and Varithena.^[3] Polidocanol causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity.

The FDA has approved polidocanol injections for the treatment of small varicose (less than 1 mm in diameter) and reticular veins (1 to 3 mm in diameter). Polidocanol works by damaging the cell lining of blood vessels, causing them to close and eventually be replaced by other types of tissue.^[4]^[5]

Pure polidocanol for pharmaceutical use

References

^ "E45 itch relief cream". netdoctor.co.uk. Retrieved 2007-07-12.
^ Sclerotherapy, Laurence Z Rosenberg, MD, eMedicine.com
^ "Varithena™ (polidocanol injectable foam) For Intravenous Use. Full Prescribing Information" (PDF). Biocompatibles, Inc. Retrieved 1 October 2015.
^ Facts and Companies: Varicose Vein Treatment Approved
^ "Asclera Full Prescribing Information in Drug Reference Encyclopedia". Retrieved 2010-04-11.

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This dermatologic drug article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 下肢静脈治療のための液体、フォーム、およびグルー硬化療法の手技 liquid foam and glue sclerotherapy techniques for the treatment of lower extremity veins
2. 出血性消化性潰瘍の治療の概要 overview of the treatment of bleeding peptic ulcers
3. 下肢慢性静脈疾患の概要およびマネージメント overview and management of lower extremity chronic venous disease
4. 消化管におけるエンドクリップ療法：出血性病変および病変外での出血 endoclip therapy in the gastrointestinal tract bleeding lesions and beyond
5. 上顆炎（テニス肘およびゴルフ肘） epicondylitis tennis and golf elbow

English Journal

The long-term efficacy of hydrocele treatment with aspiration and sclerotherapy with polidocanol compared to placebo: a prospective, double-blind, randomized study.

Lund L1, Kloster A2, Cao T2.Author information 1Department of Urology, Odense University Hospital, Odense, Denmark; Viborg Hospital, Viborg, Denmark. Electronic address: Lars.Lund@rsyd.dk.2Viborg Hospital, Viborg, Denmark.AbstractPURPOSE: We evaluate whether aspiration and sclerosing of hydrocele testis is an effective treatment.
The Journal of urology.J Urol.2014 May;191(5):1347-50. doi: 10.1016/j.juro.2013.11.025. Epub 2013 Nov 18.
PURPOSE: We evaluate whether aspiration and sclerosing of hydrocele testis is an effective treatment.MATERIALS AND METHODS: Men with symptomatic hydrocele testis were included in this prospective, double-blind, randomized study with polidocanol and placebo. Patients were randomized to active treatme
PMID 24262498

The VANISH-2 study: a randomized, blinded, multicenter study to evaluate the efficacy and safety of polidocanol endovenous microfoam 0.5% and 1.0% compared with placebo for the treatment of saphenofemoral junction incompetence.

Todd KL 3rd1, Wright D; the VANISH-2 Investigator Group.Author information 1Southeast Vein and Laser Center, Dothan, AL, USA.AbstractOBJECTIVE: To determine efficacy and safety of polidocanol endovenous microfoam in treatment of symptoms and appearance in patients with saphenofemoral junction incompetence due to reflux of the great saphenous vein or major accessory veins.
Phlebology / Venous Forum of the Royal Society of Medicine.Phlebology.2014 Apr 14. [Epub ahead of print]
OBJECTIVE: To determine efficacy and safety of polidocanol endovenous microfoam in treatment of symptoms and appearance in patients with saphenofemoral junction incompetence due to reflux of the great saphenous vein or major accessory veins.METHOD: Patients were randomized equally to receive polidoc
PMID 23864535

Combination therapy of hyaluronic acid mesotherapic injections and sclerotherapy for treatment of lower leg telangiectasia without major venous insufficiency: a preliminary clinical study.

Iannitti T1, Rottigni V, Torricelli F, Palmieri B.Author information 11Department of Physiology, School of Medicine, University of Kentucky Medical Center, Lexington, KY, USA.AbstractBACKGROUND: Telangiectasia is the dilation of dermal capillaries mainly due to hypertension and vein insufficiency. Treatments of choice for this condition are sclerotherapy with foam liquid or intradermal fiber optic laser energy delivery.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.Clin Appl Thromb Hemost.2014 Apr;20(3):326-30. doi: 10.1177/1076029612461844. Epub 2012 Oct 17.
BACKGROUND: Telangiectasia is the dilation of dermal capillaries mainly due to hypertension and vein insufficiency. Treatments of choice for this condition are sclerotherapy with foam liquid or intradermal fiber optic laser energy delivery.AIM: The aim of this study was to assess the efficacy of a n
PMID 23076772

Japanese Journal

ポリドカノールによる硬化療法を行った口腔内血管腫の1例

橘寛彦,吉田孝史,石川恵生 [他]
日本口腔外科学会雑誌 = Japanese journal of oral and maxillofacial surgery 58(11), 660-664, 2012-11
NAID 40019499495

大伏在静脈本幹のエコーガイド下フォーム硬化療法の有用性について

久米博子,佐藤彰治,藤田聡子,加賀山知子,岩井武尚
静脈学 23(1), 1-5, 2012-02-25
… Foam sclerosant was made by Tessari method, consist of 3%Polidocanol and CO2 in the proportion of 1 : 3. …
NAID 10030353035

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「ポリドカノール」

Polidocanol
Systematic (IUPAC) name
	3,6,9,12,15,18,21,24,27-nonaoxanonatriacontan-1-ol
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy; category	Topical: allowed; Injection: contraindication in months 1–3 and after week 36;
Routes of; administration	topical, subcutaneous injection
Legal status	OTC (topical), ℞ (injection);
Identifiers
CAS Number	9002-92-0 ; 3055-99-0
ATC code	C05BB02 (WHO)
PubChem	CID 656641
ChemSpider	570993
UNII	0AWH8BFG9A
KEGG	D01993
ChEMBL	CHEMBL1201751
Synonyms	Polydocanol; Laureth 9; Macrogol lauryl ether; Lauromacrogol; PEG-9 lauryl alcohol; POE-9 lauryl alcohol; Dodecylpolyethyleneglycolether; Hydroxyl polyethoxy dodecane; Oxypolyethoxydodecane;
Chemical data
Formula	C30H62O10
Molar mass	582.8073 g/mol (predicted)
	SMILES CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ;
	InChI InChI=1S/C30H62O10/c1-2-3-4-5-6-7-8-9-10-11-13-32-15-17-34-19-21-36-23-25-38-27-29-40-30-28-39-26-24-37-22-20-35-18-16-33-14-12-31/h31H,2-30H2,1H3 ; Key:ONJQDTZCDSESIW-UHFFFAOYSA-N ;
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　　[★]

英: polidocanol
同: ポリエチレングリコールモノドデシルエーテル polyethylene glycol monododecyl ether
商: エトキシスクレロール Aethoxysklerol、ポリドカスクレロール
関: 食道静脈瘤、静脈瘤; 止血剤

[1] "E45 itch relief cream". netdoctor.co.uk. Retrieved 2007-07-12.

[2] Sclerotherapy, Laurence Z Rosenberg, MD, eMedicine.com

[3] "Varithena™ (polidocanol injectable foam) For Intravenous Use. Full Prescribing Information" (PDF). Biocompatibles, Inc. Retrieved 1 October 2015.

[4] Facts and Companies: Varicose Vein Treatment Approved

[5] "Asclera Full Prescribing Information in Drug Reference Encyclopedia". Retrieved 2010-04-11.

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polidocanol