PrepTutorEJDIC

真皮(true skin),皮膚

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/03/07 12:32:34」(JST)

wiki en

Poikiloderma is a skin condition that "consists of areas of increased and decreased pigmentation, prominent blood vessels, and thinning of the skin."^[1]

Poikiloderma is most frequently seen on the chest or the neck, characterized by red colored pigment on the skin that is commonly associated with sun damage.

Health Risks

It is a condition that may present a cosmetic nuisance, yet it poses no health risks on its own.^[2]

Cause

The exact cause of poikiloderma is unknown; however, extended sun exposure, namely the ultraviolet light emitted by the sun, is the primary factor.^[3]

Treatment

Albeit difficult, treatment of poikiloderma involves the delivery of multiple wavelengths of intense pulsed light (IPL) to the affected area.^[4]

Types include:

Poikiloderma vasculare atrophicans
Poikiloderma of Civatte
Hereditary sclerosing poikiloderma

References

^ Understanding Rothmund-Thomson Syndrome, Brochure produced by the RTS research group: Lisa L. Wang, MD, Moise L. Levy, MD, Richard A. Lewis, MD, Sharon E. Plon, MD, Ta-Tara Rideau.
^ Celibre Medical "Poikiloderma More Information", Celibre.com, referenced July 22, 2011.
^ American Osteopathic College of Dermatology "Dermatologic Disease Database", aocd.org, referenced July 22, 2011.
^ PubMed.gov "Treatment of poikiloderma of Civatte with an intense pulsed light source", PubMed.gov, referenced July 22, 2011.

This cutaneous condition article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 光線過敏症（光線皮膚症）：臨床症状、診断、および治療 photosensitivity disorders photodermatoses clinical manifestations diagnosis and treatment
2. 顔面紅斑が認められる患者に対するアプローチ approach to the patient with facial erythema
3. 菌状息肉腫およびSézary症候群の病期分類と予後 staging and prognosis of mycosis fungoides and sezary syndrome
4. 斑状の皮膚病変を有する患者へのアプローチ approach to the patient with macular skin lesions
5. 移植片対宿主病（GVHD）の皮膚症状 cutaneous manifestations of graft versus host disease gvhd

English Journal

A patient with polymerase E1 deficiency (POLE1): clinical features and overlap with DNA breakage/instability syndromes.

Thiffault I1,2, Saunders C3,4,5, Jenkins J6,7,8, Raje N9, Canty K10, Sharma M11, Grote L12,13,14, Welsh HI15,16,17, Farrow E18, Twist G19, Miller N20, Zwick D21, Zellmer L22, Kingsmore SF23,24,25,26, Safina NP27,28,29.
BMC medical genetics.BMC Med Genet.2015 May 7;16(1):31. [Epub ahead of print]
BACKGROUND: Chromosome instability syndromes are a group of inherited conditions associated with chromosomal instability and breakage, often leading to immunodeficiency, growth retardation and increased risk of malignancy.CASE PRESENTATION: We performed exome sequencing on a girl with a suspected ch
PMID 25948378

Incomplete splicing of neutrophil-specific genes affects neutrophil development in a zebrafish model of poikiloderma with neutropenia.

Patil P1, Uechi T, Kenmochi N.
RNA biology.RNA Biol.2015 Apr 3;12(4):426-34. doi: 10.1080/15476286.2015.1017240.
Poikiloderma with neutropenia (PN) is a rare inherited disorder characterized by poikiloderma, facial dysmorphism, pachyonychia, short stature and neutropenia. The molecular testing of PN patients has identified mutations in the C16orf57 gene, which encodes a protein referred to as USB1 (U Six Bioge
PMID 25849198

Poikiloderma vasculare atrophicans showing features of ashy dermatosis in the beginning.

Jeon J1, Kim JH1, Ahn JW1, Song HJ1.
Annals of dermatology.Ann Dermatol.2015 Apr;27(2):197-200. doi: 10.5021/ad.2015.27.2.197. Epub 2015 Mar 24.
Poikiloderma vasculare atrophicans (PVA) is a rare poikilodermatous variant of early-stage mycosis fungoides characterized by generalized poikiloderma, atrophy, mottled dyspigmentation, and telangiectasia. In 2001, a 14-year-old male presented with asymptomatic brownish-gray polymorphic macules thro
PMID 25834361