ピロミド酸
WordNet
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
PrepTutorEJDIC
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/17 18:10:44」(JST)
[Wiki en表示]
Piromidic acid
|
Systematic (IUPAC) name |
8-Ethyl-5-oxo-2-pyrrolidin-1-yl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Identifiers |
ATC code
|
J01MB03 |
PubChem |
CID 4855 |
ChemSpider |
4689 |
UNII |
3I12WH4EWF Y |
KEGG |
D01431 |
Chemical data |
Formula |
C14H16N4O3 |
Molecular mass
|
288.30 g/mol |
SMILES
- CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCCC3)C(=O)O
|
InChI
-
InChI=1S/C14H16N4O3/c1-2-17-8-10(13(20)21)11(19)9-7-15-14(16-12(9)17)18-5-3-4-6-18/h7-8H,2-6H2,1H3,(H,20,21)
Key:RCIMBBZXSXFZBV-UHFFFAOYSA-N
|
Piromidic acid is a quinolone antibiotic.[1]
References
- ^ Minami, Shinsaku; Shono, Toshihiro; Matsumoto, Jun-Ichi (1971). "Pyrido [2, 3-d] pyrimidine Antibacterial Agents. II. Piromidic Acid and Related Compounds". Chemical and Pharmaceutical Bulletin 19 (7): 1426–1432. doi:10.1248/cpb.19.1426.
Antibacterials: nucleic acid inhibitors (J01E, J01M)
|
|
Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis) |
DHFR inhibitor |
- 2,4-Diaminopyrimidine
- Brodimoprim
- Diaveridine
- Iclaprim†
- Ormetoprim
- Trimethoprim#
- Tetroxoprim
|
|
Sulfonamides
(DHPS inhibitor) |
Short-
acting |
- Sulfaisodimidine
- Sulfamethizole
- Sulfadimidine
- Sulfapyridine
- Sulfafurazole
- Sulfanilamide
- Sulfathiazole
- Sulfathiourea
|
|
Intermediate-
acting |
- Sulfamethoxazole
- Sulfadiazine#
- Sulfamoxole
|
|
Long-
acting |
- Sulfadimethoxine
- Sulfadoxine
- Sulfalene
- Sulfametomidine
- Sulfametoxydiazine
- Sulfamethoxypyridazine
- Sulfaperin
- Sulfamerazine
- Sulfaphenazole
- Sulfamazone
|
|
Other/ungrouped |
- Sulfacetamide
- Sulfadicramide
- Sulfametrole
|
|
|
Combinations |
- Trimethoprim/sulfamethoxazole#
|
|
|
Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication) |
1st g. |
- Cinoxacin‡
- Flumequine
- Nalidixic acid
- Oxolinic acid
- Pipemidic acid
- Piromidic acid
- Rosoxacin
|
|
Fluoro-
quinolones |
2nd g. |
- Ciprofloxacin#
- Enoxacin‡
- Fleroxacin‡
- Lomefloxacin
- Nadifloxacin
- Ofloxacin
- Norfloxacin
- Pefloxacin
- Rufloxacin
|
|
3rd g. |
- Balofloxacin
- Grepafloxacin‡
- Levofloxacin
- Pazufloxacin
- Sparfloxacin‡
- Temafloxacin‡
- Tosufloxacin
|
|
4th g. |
- Besifloxacin
- Clinafloxacin†
- Garenoxacin
- Gemifloxacin
- Moxifloxacin
- Gatifloxacin‡
- Sitafloxacin
- Trovafloxacin‡/Alatrofloxacin‡
- Prulifloxacin
|
|
Vet. |
- Danofloxacin
- Difloxacin
- Enrofloxacin
- Ibafloxacin
- Marbofloxacin
- Orbifloxacin
- Pradofloxacin
- Sarafloxacin
|
|
Related (DG) |
- Aminocoumarins: Novobiocin
|
|
|
|
Anaerobic DNA
inhibitors |
Nitro- imidazole derivatives |
- Metronidazole#
- Tinidazole
- Ornidazole
|
|
Nitrofuran derivatives |
- Nitrofurantoin#
- Furazolidone‡
- Nifurtoinol
|
|
|
RNA synthesis |
Rifamycins/
RNA polymerase |
- Rifampicin#
- Rifabutin
- Rifapentine
- Rifaximin
|
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Index of bacterial disease
|
|
Description |
|
|
Disease |
- Gram-positive firmicutes
- Gram-positive actinobacteria
- Gram-negative proteobacteria
- Gram-negative non-proteobacteria
- Cholera
- Tuberculosis
|
|
Treatment |
- Antibiotics
- cell wall
- nucleic acid
- mycobacteria
- protein synthesis
- other
- Antibodies
- Vaccines
|
|
|
UpToDate Contents
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English Journal
- Removal of quinolone antibiotics from wastewaters by sorption and biological degradation in laboratory-scale membrane bioreactors.
- Dorival-García N1, Zafra-Gómez A, Navalón A, González J, Vílchez JL.
- The Science of the total environment.Sci Total Environ.2013 Jan 1;442:317-28. doi: 10.1016/j.scitotenv.2012.10.026. Epub 2012 Nov 22.
- Laboratory-scale batch experiments were developed to investigate the main removal routes for 6 commonly found quinolones (ciprofloxacin, moxifloxacin, norfloxacin, ofloxacin, pipemidic acid, and piromidic acid), in wastewaters from a wastewater treatment plant, at μg L(-1) levels in an aerobic slud
- PMID 23178836
- Laser diode thermal desorption mass spectrometry for the analysis of quinolone antibiotic residues in aquacultured seafood.
- Lohne JJ1, Andersen WC, Clark SB, Turnipseed SB, Madson MR.
- Rapid communications in mass spectrometry : RCM.Rapid Commun Mass Spectrom.2012 Dec 30;26(24):2854-64. doi: 10.1002/rcm.6414.
- RATIONALE: Veterinary drug residue analysis of meat and seafood products is an important part of national regulatory agency food safety programs to ensure that consumers are not exposed to potentially dangerous substances. Complex tissue matrices often require lengthy extraction and analysis procedu
- PMID 23136016
- Trace analysis of quinolone and fluoroquinolone antibiotics from wastewaters by liquid chromatography-electrospray tandem mass spectrometry.
- Xiao Y1, Chang H, Jia A, Hu J.
- Journal of chromatography. A.J Chromatogr A.2008 Dec 19;1214(1-2):100-8. doi: 10.1016/j.chroma.2008.10.090. Epub 2008 Oct 31.
- A sensitive liquid chromatography-electrospray tandem mass spectrometry method, combined with solid-phase extraction and a weak cation exchange cartridge cleanup, was established for twenty quinolone and fluoroquinolone antibiotics (pipemidic acid, flerofloxacin, ofloxacin, pefloxacin, enoxacin, nor
- PMID 19007934
Japanese Journal
- 難水溶性製剤の溶出試験に界面活性剤として使用されるラウリル硫酸ナトリウムの品質に関する研究(第2報)
- Determination of piromidic acid residues in trout muscle tissue and in urine by liquid chromatography with post-column modification of pH and fluorimetric detection
- Journal of chromatography. B, Biomedical sciences and applications 718(1), 135-141, 1998-10-23
- NAID 10024532764
- Effect of Drug-metabolizing Enzyme Activity Induced by PCB on the Residence Time of Oxolinic Acid, Piromidic Acid and Nalidixic Acid in Carp
Related Links
- 8-Ethyl-5-oxo-2-pyrrolidin-1-yl-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid. Clinical data. AHFS/Drugs.com · International Drug Names · Pregnancy cat. ? Legal status ? Identifiers. ATC code · J01MB03 ... Piromidic acid is a quinolone.
- Buy Piromidic Acid (CAS 19562-30-2), gram-negative antimicrobial, from Santa Cruz Biotechnology. Molecular Formula C14H16N4O3, Molecular Weight 288.3.
★リンクテーブル★
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- 英
- piromidic acid, PA
- ラ
- acidum piromidicum
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