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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/16 22:02:39」(JST)

Piperidolate is an antimuscarinic.

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English Journal

Kelkar MS.AbstractThe mouse writhing test has been used to evaluate analgesic drugs. In the present work the protective effect of atropine sulfate and eight of its substitutes was studied against acetic acid-induced writhing in mice. This was compared with the protection afforded by noramidopyrine, a non-narcotic analgesic. Both the time of onset of writhing and the number of writhes over a period of 15 min was recorded. The results seem to indicate some correlation between chemical structure and protective effect. Dicyclomine hydrochloride and orphenadrine hydrochloride produced an effect comparable with that of noramidopyrine, while atropine sulphate, oxyphenonium bromide and piperidolate hydrochloride were less potent. Homatropine methylbromide, mepenzolate methylbromide, amprotropine phosphate and penthienate bromide were ineffective.
Archives internationales de pharmacodynamie et de therapie.Arch Int Pharmacodyn Ther.1977 Sep;229(1):133-7.
The mouse writhing test has been used to evaluate analgesic drugs. In the present work the protective effect of atropine sulfate and eight of its substitutes was studied against acetic acid-induced writhing in mice. This was compared with the protection afforded by noramidopyrine, a non-narcotic ana
PMID 931459

Aggregation of antiacetylcholine drugs in aqueous solution: micellar properties of some diphenylmethane derivatives.

Attwood D.AbstractLight scattering methods have been used to examine the aggregation in aqueous solution of a series of antiacetylcholine drugs based on the diphenylmethane nucleus. The drugs investigated included adiphenine hydrochloride, piperidolate hydrochloride, benztropine mesylate, orphenadrine hydrochloride, chlorphenoxamine hydrochloride, lachesine hydrochloride, poldine methylsulphate, pipenzolate bromide, clidinium bromide, benzilonium bromide and ambutonium bromide. A micellar pattern of association was established for all compounds and critical micellar concentrations and aggregation numbers have been determined.
The Journal of pharmacy and pharmacology.J Pharm Pharmacol.1976 May;28(5):407-9.
Light scattering methods have been used to examine the aggregation in aqueous solution of a series of antiacetylcholine drugs based on the diphenylmethane nucleus. The drugs investigated included adiphenine hydrochloride, piperidolate hydrochloride, benztropine mesylate, orphenadrine hydrochloride,
PMID 6747

Micellization of an Aqueous Solution of Piperidolate Hydrochloride in the Presence of Acetylcholine Chloride

横山祥子,藤野美弘,川本嘉子,金子明子,藤江忠雄
Chemical & pharmaceutical bulletin 42(6), 1351-1353, 1994-06-15
… The surface tension of an aqueous solution of piperidolate hydrochloride (PIH), which is an anti-cholinergic drug, was measured with a Du Nouy tensiometer at 25℃ in the absence and presence of acetylcholine chloride(Ach・Cl), and the effect of Ach・Cl on the critical micelle concentration (cmc) of PIH was investigated by comparing it with the effects of sodium chloride (NaCl) and calcium chloride (CaCl_2). …
NAID 110003631142

リンク元	「ピペリドレート」
拡張検索	「piperidolate hydrochloride」

Piperidolate
Systematic (IUPAC) name
	1-Ethylpiperidin-3-yl diphenylacetate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
ATC code	A03AA30
PubChem	CID 4839
UNII	RJO31255V9
KEGG	D08382
ChEMBL	CHEMBL1474977
Chemical data
Formula	C21H25NO2
Mol. mass	323.43 g/mol
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